2024
White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairmentEmergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions
Al Kasab S, Nguyen T, Derdeyn C, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat O, de Havenon A. Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions. Stroke 2024, 55: 355-365. PMID: 38252763, DOI: 10.1161/strokeaha.123.043635.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisVessel occlusionRecurrence riskEarly recurrence riskHigh-risk patientsAggressive medical managementRecurrent stroke riskEndovascular therapyHemodynamic failureTreatment strategiesPerfusion imagingAdvanced ageEndovascular interventionIntracranial stenosisMedical managementRisk factorsHigh riskAdvanced imagingAtherosclerotic stenosisStroke riskOcclusionStenosisPatientsRisk
2017
Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage
McNally JS, Kim SE, Mendes J, Hadley JR, Sakata A, De Havenon AH, Treiman GS, Parker DL. Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage. Magnetic Resonance Insights 2017, 10: 1178623x17694150. PMID: 28469441, PMCID: PMC5348123, DOI: 10.1177/1178623x17694150.Peer-Reviewed Original ResearchCarotid intraplaque hemorrhageFuture stroke riskIntraplaque hemorrhageStroke riskCarotid artery atherosclerosisPercent diameter stenosisMagnetic resonance imaging (MRI) detectionT1-weighted MRI sequencesMagnetic resonance imaging sequenceArtery atherosclerosisIschemic strokeStroke etiologyDiameter stenosisClinical trialsHemorrhageClinical useMajor causeStroke sourcesMRI sequencesMRINeck coilImaging sequenceRiskLumenImaging
2014
Splenic rupture associated with primary CMV infection, AMSAN, and IVIG
de Havenon A, Davis G, Hoesch R. Splenic rupture associated with primary CMV infection, AMSAN, and IVIG. Journal Of Neuroimmunology 2014, 272: 103-105. PMID: 24856574, DOI: 10.1016/j.jneuroim.2014.05.004.Peer-Reviewed Original ResearchConceptsPrimary cytomegalovirus infectionGuillain-Barré syndromeIntravenous immunoglobulinSplenic ruptureCytomegalovirus infectionPrimary CMV infectionTwo-hit scenarioSequestration of erythrocytesExtravascular hemolytic anemiaRisk of ruptureCMV infectionRare complicationHemolytic anemiaImmunoglobulinInfectionSyndromeRuptureTreatmentRiskIVIGAMSANComplicationsPatientsAnemiaSpleen