2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 41: 91-99. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressure
2021
Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery
Al-Kawaz MN, Li Y, Thompson RE, Avadhani R, de Havenon A, Gruber J, Awad I, Hanley DF, Ziai W. Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery. Frontiers In Neurology 2021, 12: 729831. PMID: 34512537, PMCID: PMC8427275, DOI: 10.3389/fneur.2021.729831.Peer-Reviewed Original ResearchCerebral perfusion pressureLong-term mortalityHigh intracranial pressureIntracranial pressureCPP readingsTerm mortalityPerfusion pressureIntracerebral hemorrhageMIS groupControl groupLarge Spontaneous Intracerebral HemorrhageICP readingsInvasive surgeryHematoma volume reductionBlinded outcome assessmentShort-term mortalitySpontaneous intracerebral hemorrhageSpontaneous intracranial hemorrhageMultiple logistic regressionMIS patientsMISTIE IIISecondary outcomesPrimary outcomeHigher proportionIntracranial hemorrhage