2024
Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials
de Havenon A, Viscoli C, Kleindorfer D, Sucharew H, Delic A, Becker C, Robinson D, Yaghi S, Li V, Lansberg M, Cramer S, Mistry E, Sarpong D, Kasner S, Kernan W, Sheth K. Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials. JAMA Network Open 2024, 7: e2423677. PMID: 39028666, PMCID: PMC11259901, DOI: 10.1001/jamanetworkopen.2024.23677.Peer-Reviewed Original ResearchConceptsPrevention trialsPoststroke disabilityRecurrent stroke ratesRecurrent strokeCohort studyRate of recurrent strokeStroke Prevention TrialIncreased hazardInsulin Resistance InterventionSecondary prevention trialsBaseline disabilityAssociated with increased ratesStroke rateMain OutcomesFunctional statusResistance InterventionStudy baselineSecondary outcomesPrimary outcomeWorsening heart failureModified Rankin ScaleProfession's participationLong-term followVascular deathDisabilityCost-benefit analysis of intraoperative neuromonitoring for cardiac surgery
Jain B, Rahim F, Thirumala P, McGarvey M, Balzer J, Nogueira R, van der Goes D, de Havenon A, Sultan I, Ney J. Cost-benefit analysis of intraoperative neuromonitoring for cardiac surgery. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107576. PMID: 38232584, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107576.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionCardiac surgeryIntraoperative neuromonitoringModified Rankin ScaleDetect large vessel occlusionHigh-risk patientsOne-way sensitivity analysesLifetime costsProbabilistic sensitivity analysesNeurological complicationsRankin ScaleSurgeryFunctional outcomesLifetime horizonVessel occlusionPatientsDecision-analysis treeSocietal perspectiveNeuromonitoringCost-saving
2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization
Frontera J, Sabadia S, Yang D, de Havenon A, Yaghi S, Lewis A, Lord A, Melmed K, Thawani S, Balcer L, Wisniewski T, Galetta S, Agarwal S, Andino A, Arena V, Baskharoun S, Bauman K, Bell L, Berger S, Bhagat D, Bokhari M, Bondi S, Canizares M, Chervinsky A, Czeisler B, Dygert L, Fang T, Flusty B, Friedman D, Friedman D, Fuchs B, Granger A, Gratch D, Gurin L, Gutman J, Hasanaj L, Holmes M, Horng J, Huang J, Ishii H, Jauregui R, Ji Y, Kahn D, Koch E, Krieger P, Kvernland A, Lalchan R, Lillemoe K, Lin J, Liu S, Madhavan M, Medicherla C, Millar-Vernetti P, Morgan N, Olivera A, Omari M, Park G, Patel P, Ristic M, Rosenthal J, Sonson M, Snyder T, Stainman R, Sunwoo B, Talmasov D, Tamimi M, Thomas B, Valdes E, Zhou T, Zhu Y. Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization. Journal Of The Neurological Sciences 2022, 443: 120487. PMID: 36379135, PMCID: PMC9637014, DOI: 10.1016/j.jns.2022.120487.Peer-Reviewed Original ResearchConceptsModified Rankin ScalePost-acute symptomsLong-term outcomesCOVID-19 hospitalizationBaseline disabilityBarthel IndexPoor outcomeFemale sexLife stressorsCOVID-19Telephone Montreal Cognitive AssessmentOlder ageMultivariable logistic regressionStrong independent predictorCOVID-19 patientsLongitudinal cohort studyCOVID-19 severityWorse mRSMontreal Cognitive AssessmentProlonged symptomsRankin ScaleCohort studyIndependent predictorsMultivariable analysisNeuropsychiatric outcomes
2021
Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke
de Havenon A, Tirschwell DL, Heitsch L, Cramer SC, Braun R, Cole J, Reddy V, Majersik JJ, Lindgren A, Worrall BB. Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke. Neurology Clinical Practice 2021, 11: e239-e244. PMID: 34484897, PMCID: PMC8382369, DOI: 10.1212/cpj.0000000000000954.Peer-Reviewed Original ResearchModified Rankin ScaleTrial's primary outcomePrimary outcomeIschemic strokeDay 90Stroke onsetStroke trialsStroke (NINDS) rt-PA Stroke StudyModified Rankin Scale scoreAcute ischemic strokeProportion of patientsIschemic stroke onsetRankin Scale scoreClinical trial designTraditional outcome measuresMRS improvementMRS shiftStroke IIIRecurrent strokeRankin ScaleInterventional managementClinical evolutionStroke StudyRehabilitative therapyAlbumin treatment
2020
Primary Outcome and Intrapatient Stability of the Modified Rankin Scale Between Day 90 and 365 After Stroke Onset: A Secondary Analysis of the NINDS tPA and IMS III Trials (1056)
de Havenon A, Tirschwell D, Heitsch L, Reddy V, Majersik J, Worrall B. Primary Outcome and Intrapatient Stability of the Modified Rankin Scale Between Day 90 and 365 After Stroke Onset: A Secondary Analysis of the NINDS tPA and IMS III Trials (1056). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1056.Peer-Reviewed Original ResearchIMS III trialModified Rankin Scale
2019
Results From DEFUSE 3
de Havenon A, Mlynash M, Kim-Tenser MA, Lansberg MG, Leslie-Mazwi T, Christensen S, McTaggart RA, Alexander M, Albers G, Broderick J, Marks MP, Heit JJ, Investigators O. Results From DEFUSE 3. Stroke 2019, 50: 632-638. PMID: 30726184, PMCID: PMC6628906, DOI: 10.1161/strokeaha.118.023407.Peer-Reviewed Original ResearchConceptsIschemic core volumeLarge vessel occlusionEndovascular thrombectomyCollateral statusTomography angiographyFunctional independenceDEFUSE 3Poor collateralsLeptomeningeal collateralsStroke patientsVessel occlusionGood collateralsAnterior circulation large vessel occlusionBaseline ischemic core volumeSmall ischemic core volumeAcute ischemic stroke patientsDEFUSE 3 patientsIschemic stroke patientsModified Rankin ScaleStroke-related deathComputed tomography angiographyGood leptomeningeal collateralsTreatment effectsNeurological outcomePrespecified analysis
2018
Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage
de Havenon A, Majersik JJ, Stoddard G, Wong KH, McNally JS, Smith AG, Rost NS, Tirschwell DL. Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage. Stroke 2018, 49: 1981-1984. PMID: 30012822, PMCID: PMC6202185, DOI: 10.1161/strokeaha.118.022133.Peer-Reviewed Original ResearchConceptsBlood pressure variabilitySystolic blood pressure variabilitySystolic blood pressureNeurological outcomeRankin ScaleBlood pressureAcute periodIntracerebral hemorrhageWorse outcomesPressure variabilityLong-term neurological outcomeUtility-weighted modified Rankin scaleWorse neurological outcomeAcute ischemic strokeModified Rankin ScaleBlood pressure meansATACH-2 trialProtocol-based approachATACH-2Ischemic strokeSecondary outcomesPrimary outcomeEarly identificationSecondary analysisConsistent associationIncreased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome
Bennett AE, Wilder MJ, McNally JS, Wold JJ, Stoddard GJ, Majersik JJ, Ansari S, de Havenon A. Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome. Journal Of NeuroInterventional Surgery 2018, 10: 823. PMID: 29352059, DOI: 10.1136/neurintsurg-2017-013473.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleBlood pressure variabilityIntra-arterial therapyIntravenous tissue plasminogen activatorPressure variabilityTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsIschemic strokeWorse outcomesMean age 63.2 yearsMedian admission National InstitutesMultivariable ordinal logistic regression modelsSystolic blood pressure variabilityPlasminogen activatorAdmission National InstitutesWorse neurologic outcomeWorse clinical outcomesLogistic regression analysisOrdinal logistic regression analysisIndependent predictive abilitySuccessive variationAcute strokeEndovascular thrombectomyNeurologic outcome