Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusionImpaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volume