2024
Trends in cerebral venous thrombosis before and during the COVID-19 pandemic: Analysis of the National Inpatient Sample
Klein P, Shu L, Qureshi M, Abdalkader M, Field T, Siegler J, Zhou L, Patel K, Al Kasab S, de Havenon A, Yaghi S, Qureshi A, Nguyen T. Trends in cerebral venous thrombosis before and during the COVID-19 pandemic: Analysis of the National Inpatient Sample. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107651. PMID: 38408574, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107651.Peer-Reviewed Original ResearchCerebral venous thrombosisIn-hospital mortalityAssociated with in-hospital mortalityCVT incidenceNational Inpatient SampleIntracranial hemorrhageVenous thrombosisAtrial fibrillationMale sexPredictors of in-hospital mortalityAll-cause in-hospital mortalityIncidence of cerebral venous thrombosisInpatient SampleIncreasing ageStroke diagnosisCOVID-19 pandemicNationally representative estimatesICD-10 codesQuartile of incomeCensus dataMedian NIHSSProthrombotic stateHematological conditionsJoinpoint regressionMultivariate analysisBlood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke
Katsanos A, Joundi R, Palaiodimou L, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Tsioufis K, Malhotra K, Spiotta A, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke. Hypertension 2024, 81: 629-635. PMID: 38164751, PMCID: PMC11289690, DOI: 10.1161/hypertensionaha.123.22164.Peer-Reviewed Original ResearchAcute ischemic strokeEndovascular thrombectomyIschemic strokeSBP trajectoriesOdds ratioSystolic blood pressure trajectoriesEarly neurological deteriorationSevere stroke syndromesVascular risk factorsBlood pressure valuesStudy of patientsBlood pressure trajectoriesTrajectory groupsMixed effects regression modelsStroke syndromeSuccessful recanalizationTotal patientsNeurological deteriorationAdjusted analysisIntracranial hemorrhagePotential confoundersRisk factorsCommon odds ratioHigh prevalenceSBP measurements
2023
Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis
Palaiodimou L, Joundi R, Katsanos A, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Malhotra K, Spiotta A, Vassilopoulou S, Tsioufis K, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis. European Stroke Journal 2023, 9: 88-96. PMID: 37921233, PMCID: PMC10916831, DOI: 10.1177/23969873231211157.Peer-Reviewed Original ResearchBlood pressure variabilitySymptomatic intracranial hemorrhageAcute ischemic strokeEndovascular thrombectomyFunctional impairmentIschemic strokeHighest tertileAIS patientsPressure variabilityIndividual BP measurementsMean BP levelsDiastolic BP levelsIndividual patient dataLogistic mixed-effects modelsSBP-CVSBP-SDIntravenous thrombolysisStroke outcomeStroke severitySuccessful recanalizationBP levelsIntracranial hemorrhageBP measurementsHigh mortalityTertileRESCUE‐ICAS: Rationale and Study Design
Almallouhi E, de Havenon A, Asi K, Limaye K, Maier I, Starke R, Psychogios M, Inoa V, Grossberg J, Mascitelli J, Samaniego E, Fragata I, Kass‐Hout T, Capasso F, Dmytriw A, Jehani H, Modovan K, Yaghi S, Ezzeldin M, Grandhi R, Wolfe S, Fargen K, Jabbour P, Naamani K, Spiotta A, Zaidat O, Kasab S. RESCUE‐ICAS: Rationale and Study Design. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.122.000530.Peer-Reviewed Original ResearchICAS-LVORescue therapyIntracranial stenosisCerebral Infarction scoreMechanical thrombectomy failureSymptomatic intracranial hemorrhageProspective cohort studyLarge vessel occlusionRankin Scale scoreOptimal treatment strategyThrombectomy failureProspective registrySuccessful recanalizationCohort studyModified thrombolysisAtherosclerotic diseaseIntracranial hemorrhageTreatment strategiesCommon causeInclusion criteriaRadiographic dataImaging variablesScale scoreMT casesPatientsComplications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Rose D, Cavalier A, Kam W, Cantrell S, Lusk J, Schrag M, Yaghi S, Stretz C, de Havenon A, Saldanha I, Wu T, Ranta A, Barber P, Marriott E, Feng W, Kosinski A, Laskowitz D, Poli S, Mac Grory B. Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Stroke 2023, 54: 1192-1204. PMID: 36951049, PMCID: PMC10133185, DOI: 10.1161/strokeaha.122.042335.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageAcute ischemic strokeIntracranial hemorrhageIschemic strokeSystematic reviewIntravenous tenecteplaseRelative riskHigh-dose groupRisk of complicationsPrior systematic reviewsTenecteplase-treated patientsFull-text articlesWeb of ScienceGastrointestinal hemorrhageAdult patientsExtracranial hemorrhageNoncomparative studySecondary outcomesPooled riskPrimary outcomeTreatment complicationsAbsolute riskCochrane LibraryInterventional studyMedium dose
2022
Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis
Yaghi S, Saldanha IJ, Misquith C, Zaidat B, Shah A, Joudi K, Persaud B, Khalek F, Shu L, de Havenon A, Mistry EA, Bakradze E, Goldstein ED, Reagan J, Theodorou A, Palaiodimou L, Furie K, Field TS, Tsivgoulis G, Mac Grory B. Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis. Stroke 2022, 53: 3014-3024. PMID: 35938419, DOI: 10.1161/strokeaha.122.039579.Peer-Reviewed Original ResearchConceptsCerebral venous thrombosisDirect oral anticoagulantsVitamin K antagonistsVenous thrombosisK antagonistsSystematic reviewRelative riskObservational studyDirect Oral Anticoagulants Versus Vitamin K AntagonistsSafety of DOACsVitamin K antagonist treatmentRecurrent venous thromboembolismHigh-level evidenceLeast moderate riskVenous recanalizationOral anticoagulantsVenous thromboembolismMajor hemorrhageMore patientsAntagonist treatmentIntracranial hemorrhageCombination of keywordsComparable efficacyInclusion criteriaSafety outcomes409 Impact of COVID-19 on the Hospitalization, Treatment, and Outcomes of Intracerebral Hemorrhage and Subarachnoid Hemorrhage in the United States
Ravindra V, Grandhi R, de Havenon A. 409 Impact of COVID-19 on the Hospitalization, Treatment, and Outcomes of Intracerebral Hemorrhage and Subarachnoid Hemorrhage in the United States. Neurosurgery 2022, 68: 94-95. DOI: 10.1227/neu.0000000000001880_409.Peer-Reviewed Original ResearchAdjusted odds ratioHospital death rateIntensive care stayIntracerebral hemorrhageFavorable dischargeIntracranial hemorrhageSubarachnoid hemorrhageCOVID-19Vizient Clinical Data BaseDeath rateLonger hospital lengthOnly small cohortsLonger hospital stayIntensive care lengthLength of hospitalOutcome of deathCohort of patientsSpontaneous intracerebral hemorrhageClinical data baseICH controlsHospital deathHospital lengthHospital stayControl patientsSecondary outcomes
2021
Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery
Al-Kawaz MN, Li Y, Thompson RE, Avadhani R, de Havenon A, Gruber J, Awad I, Hanley DF, Ziai W. Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery. Frontiers In Neurology 2021, 12: 729831. PMID: 34512537, PMCID: PMC8427275, DOI: 10.3389/fneur.2021.729831.Peer-Reviewed Original ResearchCerebral perfusion pressureLong-term mortalityHigh intracranial pressureIntracranial pressureCPP readingsTerm mortalityPerfusion pressureIntracerebral hemorrhageMIS groupControl groupLarge Spontaneous Intracerebral HemorrhageICP readingsInvasive surgeryHematoma volume reductionBlinded outcome assessmentShort-term mortalitySpontaneous intracerebral hemorrhageSpontaneous intracranial hemorrhageMultiple logistic regressionMIS patientsMISTIE IIISecondary outcomesPrimary outcomeHigher proportionIntracranial hemorrhageIschaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study
Yaghi S, Henninger N, Giles JA, Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 1062-1067. PMID: 33903185, PMCID: PMC8448925, DOI: 10.1136/jnnp-2021-326166.Peer-Reviewed Original ResearchConceptsRecurrent ischemic eventsSymptomatic intracranial hemorrhageIschemic strokeIschemic eventsAtrial fibrillationAnticoagulation therapyAcute cardioembolic strokeAnticoagulation-naïve patientsInitiation of anticoagulationStroke prevention measuresComprehensive stroke centerIschemic stroke patientsAcute ischemic strokeCox regression analysisSecondary prevention strategiesCox hazard modelSICH riskAnticoagulant therapyAnticoagulation statusStroke centersCardioembolic strokeAF patientsConsecutive patientsEarly recurrenceIntracranial hemorrhage
2020
Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
Menacho ST, Grandhi R, Delic A, Anadani M, Ziai WC, Awad IA, Hanley DF, de Havenon A. Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105540. PMID: 33360250, PMCID: PMC8080544, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105540.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Trials, Phase III as TopicDatabases, FactualFemaleHumansIntracranial HemorrhagesIntracranial PressureMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsRandomized Controlled Trials as TopicRecovery of FunctionRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsICP monitor placementNontraumatic intracranial hemorrhageIntracranial hemorrhageIntracranial pressure monitorPoor outcomeNeurologic outcomePressure monitorPropensity score-matched cohortMonitor placementIdentification of patientsSpontaneous intracranial hemorrhageExternal ventricular drainInvasive ICP monitoringLogistic regression modelsIntraparenchymal monitorsIII trialsSecondary outcomesPrimary outcomeBalanced cohortVentricular drainICP monitorICP monitoringPatientsSecondary analysisGreater riskAnticoagulation Type and Early Recurrence in Cardioembolic Stroke
Yaghi S, Mistry E, Liberman AL, Giles J, Asad SD, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Lord A, Furie K, Keyrouz S, Nouh A, Leon Guerrero CR, de Havenon A, Khan M, Henninger N. Anticoagulation Type and Early Recurrence in Cardioembolic Stroke. Stroke 2020, 51: 2724-2732. PMID: 32757753, PMCID: PMC7484360, DOI: 10.1161/strokeaha.120.028867.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsAtrial FibrillationBrain IschemiaEmbolismFemaleHeart DiseasesHeparin, Low-Molecular-WeightHumansIncidenceIntracranial HemorrhagesMaleMiddle AgedNeuroimagingRecurrenceRegistriesRetrospective StudiesRisk AssessmentStrokeTreatment OutcomeUnited StatesWarfarinConceptsSymptomatic intracranial hemorrhageRecurrent ischemic eventsLow molecular weight heparinAcute ischemic strokeMolecular weight heparinIschemic eventsIntracranial hemorrhageIschemic strokeAtrial fibrillationAnalysis inclusion criteriaEarly recurrenceWeight heparinInclusion criteriaSeparate Cox regression analysesComprehensive stroke centerLarge prospective studiesOral anticoagulant therapyCox regression analysisCox regression modelAnticoagulation typeDOAC treatmentStroke RegistryAnticoagulant therapyCardioembolic strokeStroke centersIntravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections
Chen R, Singh G, McNally JS, Palmer CA, de Havenon A. Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections. Case Reports In Neurological Medicine 2020, 2020: 6134830. PMID: 32547798, PMCID: PMC7201472, DOI: 10.1155/2020/6134830.Peer-Reviewed Original ResearchIntravascular lymphomaComplete remissionExtracranial arteriesEarly diagnosisIntravascular large B-cell lymphomaDiagnosis of IVLLarge B-cell lymphomaGood neurologic recoveryHeterogeneous clinical presentationB-cell lymphomaAggressive chemotherapyMultifocal infarctsAppropriate chemotherapyNeurologic recoveryLymphomatous cellsArterial dissectionBrain biopsyClinical presentationCNS hemorrhageProgressive strokeAtypical manifestationsIntracranial hemorrhageTissue confirmationIntraluminal proliferationSmall arteries