2022
Borderzone infarction and recurrent stroke in intracranial atherosclerosis
Kvernland A, Torres J, Raz E, Nossek E, de Havenon A, Gebregziabher M, Khatri P, Prabhakaran S, Liebeskind D, Yaghi S. Borderzone infarction and recurrent stroke in intracranial atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2022, 32: 106897. PMID: 36402094, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106897.Peer-Reviewed Original ResearchConceptsRecurrent cerebrovascular eventsIntracranial stenosisBorderzone infarctsInfarct patternsIschemic strokeBorderzone infarctionRetrospective single-center studyAcute ischemic strokeRecurrent ischemic strokeSingle-center studySymptomatic intracranial stenosisHigh-risk cohortBinary logistic regression analysisDistal blood flowAlternative treatment strategiesLogistic regression analysisLogistic regression modelsCerebrovascular eventsRecurrent strokeIntracranial atherosclerosisPrimary outcomeCenter studyMean ageSurrogate markerTreatment strategiesRescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis
Almallouhi E, Murad M, Chalhoub R, Kicielinski K, Lena J, Brennan E, Zaidat O, de Havenon A, Spiotta A, Al Kasab S. Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2022, 3 DOI: 10.1161/svin.122.000510.Peer-Reviewed Original ResearchLarge vessel occlusionEmbolic large-vessel occlusionRescue therapyICAS-LVOOutcomes of patientsVessel occlusionIntracranial atherosclerosisRescue treatmentOdds ratioSystematic reviewEmergent large vessel occlusionRescue endovascular treatmentRandom-effects modelAcute strokeBackground PatientsSuccessful recanalizationMechanical thrombectomyEndovascular treatmentBetter outcomesPatientsMeta-AnalysisCINAHL CompleteCombination of treatmentsOcclusionDatabase date
2020
Apolipoproteins, Lipoprotein(a) and Risk of Intracranial Atherosclerosis and Ischemic Stroke: A Secondary Analysis of the ARIC Study (1067)
de Havenon A, Majersik J, Sheibani N, Wong K. Apolipoproteins, Lipoprotein(a) and Risk of Intracranial Atherosclerosis and Ischemic Stroke: A Secondary Analysis of the ARIC Study (1067). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1067.Peer-Reviewed Original ResearchPoststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis
Yaghi S, Cotsonis G, de Havenon A, Prahbakaran S, Romano JG, Lazar RM, Marshall RS, Feldmann E, Liebeskind DS. Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104663. PMID: 32044220, PMCID: PMC8985650, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104663.Peer-Reviewed Original ResearchConceptsMontreal Cognitive AssessmentRecurrent ischemic strokeRecurrent strokeIschemic strokeCognitive impairmentMultivariable Cox regression modelsCognitive AssessmentAggressive medical therapyAnterior circulation stenosisIntracranial Stenosis (SAMMPRIS) trialPreventing Recurrent StrokeStroke recurrence riskLong-term morbiditySymptomatic intracranial atherosclerosisCox regression modelPoststroke cognitive impairmentMean followStroke recurrenceIntracranial atherosclerosisMedical therapyPrimary outcomeArtery stenosisIntracranial stenosisStroke patientsMean age
2019
Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis
Yaghi S, Khatri P, de Havenon A, Yeatts S, Chang AD, Cutting S, Grory B, Burton T, Jayaraman MV, McTaggart RA, Fiorella D, Derdeyn C, Zaidat OO, Dehkharghani S, Amin-Hanjani S, Furie K, Prahbakaran S, Liebeskind D. Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis. Journal Of NeuroInterventional Surgery 2019, 12: 374. PMID: 31484697, PMCID: PMC8022354, DOI: 10.1136/neurintsurg-2019-015225.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial atherosclerosisAngioplasty/stentingPrimary outcomeSAMMPRIS trialLesion lengthPeri-procedural strokeSevere intracranial stenosisStroke/deathOdds of strokeNew clinical trialsProcedure-specific variablesLogistic regression analysisPatient-specific variablesModest predictive valueSymptomatic severe intracranial stenosisIntracranial atherosclerosisSmoking historySmoking statusIntracranial stenosisFDA indicationClinical trialsPatientsReliable biomarkersStentingPredictive valueAssessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis
Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology 2019, 61: 643-650. PMID: 30675639, PMCID: PMC8022353, DOI: 10.1007/s00234-019-02167-3.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseVessel wall magnetic resonance imagingInter-rater agreementLower infundibulumHigh inter-rater agreementVessel wall magnetic resonanceGood inter-rater agreementPost-contrast imagingPresence of enhancementMagnetic resonance imagingPost-contrast imagesRatio of enhancementCulprit lesionIntracranial atherosclerosisAtherosclerotic diseaseInclusion criteriaBlinded reviewersResonance imagingLesion enhancementHigh agreementPlaque signalLesionsInfundibulumObjective dataMagnetic resonance
2017
High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease
de Havenon A, Mossa-Basha M, Shah L, Kim SE, Park M, Parker D, McNally JS. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease. Neuroradiology 2017, 59: 1193-1202. PMID: 28942481, DOI: 10.1007/s00234-017-1925-9.Peer-Reviewed Original ResearchConceptsHigh-resolution vessel wall MRIVessel wall MRIIntracranial atherosclerosisPrognosis of patientsIntracranial atherosclerotic diseasePost-contrast enhancementDiagnostic imaging techniquesHigh field strength MRIIschemic strokeStroke etiologyAtherosclerotic diseaseCerebrovascular diseaseVessel wall morphologyVascular pathologyIntracranial arteriesEnhancement patternRecurrence riskAtherosclerosisTranslational perspectiveVessel wallClinical interpretationMRIStrength MRIDisease