2021
Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19
Frontera JA, Melmed K, Fang T, Granger A, Lin J, Yaghi S, Zhou T, Lewis A, Kurz S, Kahn DE, de Havenon A, Huang J, Czeisler BM, Lord A, Meropol SB, Troxel AB, Wisniewski T, Balcer L, Galetta S. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocritical Care 2021, 35: 693-706. PMID: 33725290, PMCID: PMC7962078, DOI: 10.1007/s12028-021-01220-5.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyHospital mortalityTime-dependent Cox proportional hazards modelsSequential Organ Failure Assessment scoreSevere acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Intensive care unit requirementSARS-CoV-2 infectionCOVID-19Cox proportional hazards modelRespiratory syndrome coronavirus 2Longer hospital lengthNew York City hospitalsPrimary neurological diagnosisStructural brain diseaseToxic-metabolic encephalopathyDate of admissionSyndrome coronavirus 2Proportional hazards modelCoronavirus disease 2019Coprimary outcomesHospital deathHospital lengthObservational cohort
2020
Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
de Havenon A, Ney JP, Callaghan B, Delic A, Hohmann S, Shippey E, Esper GJ, Stulberg E, Tirschwell D, Frontera J, Yaghi S, Anadani M, Majersik JJ. Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105535. PMID: 33310595, PMCID: PMC7832426, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105535.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeFavorable dischargeStroke patientsPrimary analysisLaboratory-confirmed COVID-19COVID-19Vizient Clinical Data BaseAcute coronary syndromeAcute renal failureCohort of patientsCoronavirus disease 2019Clinical data baseCoronary syndromeHospital deathVenous thromboembolismMechanical thrombectomyRenal failureHispanic patientsDischarge diagnosisSubarachnoid hemorrhageWorse outcomesDisease 2019High riskLower oddsCerebral Venous Sinus Thrombosis in the COVID-19 Pandemic.
Medicherla CB, Pauley RA, de Havenon A, Yaghi S, Ishida K, Torres JL. Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic. Journal Of Neuro-Ophthalmology 2020, 40: 457-462. PMID: 33186264, DOI: 10.1097/wno.0000000000001122.Peer-Reviewed Original ResearchConceptsCerebral venous sinus thrombosisVenous sinus thrombosisSinus thrombosisThromboembolic eventsRisk of CVSTNeuro-ophthalmologic complicationsSignificant visual deficitsCoronavirus disease 2019COVID-19COVID-19 pandemicNeurologic complicationsClinical presentationMultiple etiologiesDisease presentationVisual deficitsDisease 2019Disease pathophysiologyNovel COVID-19 pandemicComplicationsThrombosisVariable phenotypeRecent studiesPresentationThromboembolismPandemicA Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City
Frontera JA, Sabadia S, Lalchan R, Fang T, Flusty B, Millar-Vernetti P, Snyder T, Berger S, Yang D, Granger A, Morgan N, Patel P, Gutman J, Melmed K, Agarwal S, Bokhari M, Andino A, Valdes E, Omari M, Kvernland A, Lillemoe K, Chou SH, McNett M, Helbok R, Mainali S, Fink EL, Robertson C, Schober M, Suarez JI, Ziai W, Menon D, Friedman D, Friedman D, Holmes M, Huang J, Thawani S, Howard J, Abou-Fayssal N, Krieger P, Lewis A, Lord AS, Zhou T, Kahn DE, Czeisler BM, Torres J, Yaghi S, Ishida K, Scher E, de Havenon A, Placantonakis D, Liu M, Wisniewski T, Troxel AB, Balcer L, Galetta S. A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City. Neurology 2020, 96: 10.1212/wnl.0000000000010979. PMID: 33020166, PMCID: PMC7905791, DOI: 10.1212/wnl.0000000000010979.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBrain DiseasesCOVID-19FemaleHospital MortalityHospitalizationHumansIntubation, IntratrachealMaleMiddle AgedNervous System DiseasesNeurotoxicity SyndromesNew York CityOrgan Dysfunction ScoresPatient DischargeProspective StudiesSex FactorsSpinal Cord DiseasesYoung AdultConceptsNew neurologic disordersSARS-CoV-2 infectionLikelihood of dischargeNeurologic disordersHospital mortalityHigher Sequential Organ Failure Assessment scoreLaboratory-confirmed SARS-CoV-2 infectionSequential Organ Failure Assessment scoreCOVID-19Severe acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Hospitalized COVID-19 patientsHypoxic/ischemic injuryCOVID-19 symptom onsetRespiratory syndrome coronavirus 2Meningitis/encephalitisSevere systemic illnessCOVID-19 patientsSyndrome coronavirus 2Coronavirus disease 2019SARS-CoV-2SOFA scoreHospital outcomesHospitalized adults