The ongoing quest for biomarkers in Ankylosing Spondylitis
Danve A, O'Dell J. The ongoing quest for biomarkers in Ankylosing Spondylitis. International Journal Of Rheumatic Diseases 2015, 18: 826-834. PMID: 26469363, DOI: 10.1111/1756-185x.12779.Peer-Reviewed Original ResearchConceptsRadiographic progressionC-reactive proteinChronic inflammatory diseaseQuality of lifeDisease activityPotential clinical applicationsHLA-B27Ankylosing SpondylitisDiscovery of biomarkersInflammatory diseasesEarly diagnosisNew biomarkersSpondylitisBiomarkersDisease assessmentClinical applicationProgressionImmunopathogenesisTherapySymptomsDiseaseDiagnosisIL-17 Inhibition in Axial Spondyloarthritis
Danve A, Deodhar A. IL-17 Inhibition in Axial Spondyloarthritis. Current Treatment Options In Rheumatology 2015, 1: 221-230. DOI: 10.1007/s40674-015-0020-9.Peer-Reviewed Original ResearchIL-23/ILIL-17IL-23Monoclonal antibodiesExtra-articular manifestationsTNF-α blockadeIL-17 inhibitionIL-23 receptorQuality of lifeSignificant beneficial effectDisease activityProspective trialRadiographic progressionInhibitor medicationIL-12MRI scoresPhysical functionAxial spondyloarthritisClinical studiesP40 subunitAnimal modelsBeneficial effectsWestern populationsNovel optionSpondyloarthritis