2024
Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepression, PostpartumFemaleHumansKenyaLebanonPregnancyPsychotherapy, GroupWomen's HealthConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapy
2022
Measuring Antenatal Depressive Symptoms Across the World: A Validation and Cross-Country Invariance Analysis of the Patient Health Questionnaire-9 (PHQ-9) in Eight Diverse Low-Resource Settings
Murray A, Hemady C, Do H, Dunne M, Foley S, Osafo J, Sikander S, Madrid B, Baban A, Taut D, Ward C, Fernando A, Van Thang V, Eisner M, Hughes C, Fearon P, Valdebenito S, Tomlinson M, Pathmeswaran A, Walker S. Measuring Antenatal Depressive Symptoms Across the World: A Validation and Cross-Country Invariance Analysis of the Patient Health Questionnaire-9 (PHQ-9) in Eight Diverse Low-Resource Settings. Psychological Assessment 2022, 34: 993-1007. PMID: 36227303, DOI: 10.1037/pas0001154.Peer-Reviewed Original Research
2021
Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation
Nazzari S, Fearon P, Rice F, Molteni M, Frigerio A. Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation. Journal Of Child Psychology And Psychiatry 2021, 63: 871-880. PMID: 34787327, DOI: 10.1111/jcpp.13532.Peer-Reviewed Original ResearchConceptsInfant stress regulationInfant cortisol reactivityC-reactive proteinMaternal sensitive caregivingAntenatal stressMaternal cortisolCortisol responseInfant stress response systemsInfant cortisol regulationMaternal antenatal stressMaternal caregivingInfant cortisol responseCortisol reactivityGreater cortisol responseAntenatal exposureMaternal ageMaternal levelsInterleukin-6Late pregnancyMaternal stress signalsPostnatal depressionSensitive caregivingAnimal studiesStress regulationCortisol regulationThe impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries
Brown R, Eisner M, Walker S, Tomlinson M, Fearon P, Dunne M, Valdebenito S, Hughes C, Ward C, Sikander S, Osafo J, Madrid B, Baban A, Van Thang V, Fernando A, Murray A. The impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries. Journal Of Affective Disorders 2021, 295: 612-619. PMID: 34509077, DOI: 10.1016/j.jad.2021.08.066.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesPrenatal depressive symptomsMiddle-income countriesPrenatal depressionDepressive symptomsMaternal health careChildhood experiencesAntenatal careThird trimesterCohort evidenceACE exposureHigh-income countriesPostnatal periodExpectant mothersBaseline measurementsPostnatal attachmentSymptomsPath mediation analysisRelevant covariatesDepressionHealth careMothers' feelingsMothersPregnancyDecision-making ability, psychopathology, and brain connectivity
Moutoussis M, Garzón B, Neufeld S, Bach D, Rigoli F, Goodyer I, Bullmore E, Consortium N, Fonagy P, Jones P, Hauser T, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R, Guitart-Masip M, Dolan R. Decision-making ability, psychopathology, and brain connectivity. Neuron 2021, 109: 2025-2040.e7. PMID: 34019810, PMCID: PMC8221811, DOI: 10.1016/j.neuron.2021.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAntisocial Personality DisorderAnxietyBrainCognitionDecision MakingDepressionDepressive Disorder, MajorFactor Analysis, StatisticalFemaleFunctional NeuroimagingHumansIntelligence TestsMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPsychosocial FunctioningSelf ConceptSocial InteractionYoung AdultConceptsDecision-making abilityFunctional connectivityResting-state functional connectivityGeneral social functioningDecision-making measuresPoor social functionCognitive constructsCognitive processesBrain signaturesSocial functioningThought patternsBrain connectivityMental healthMultiple domainsSocial functionIQBrain dataCommon factorsYoung peopleConstructsIndividuals 18Neural networkConnectivityAbilityPsychopathology
2020
The biological underpinnings of perinatal depressive symptoms: A multi-systems approach.
Nazzari S, Fearon P, Rice F, Ciceri F, Molteni M, Frigerio A. The biological underpinnings of perinatal depressive symptoms: A multi-systems approach. Journal Of Affective Disorders 2020, 274: 1004-1012. PMID: 32663926, DOI: 10.1016/j.jad.2020.05.023.Peer-Reviewed Original ResearchConceptsPerinatal depressive symptomsC-reactive proteinDepressive symptomsLate pregnancyInterleukin-6Cortisol levelsHigher IL-6 levelsLower morning cortisol levelsEdinburgh Postnatal Depression ScaleAntenatal depressive symptomsStress-immune interactionsSerum interleukin-6IL-6 levelsDiurnal salivary cortisol levelsPostnatal Depression ScaleInflammatory response systemSalivary alpha-amylase levelsMorning cortisol levelsHigher depressive symptomsSalivary cortisol levelsBiological underpinningsAlpha-amylase levelsState-Trait Anxiety InventoryInflammatory biomarkersPerinatal depressionThe chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5
Hentges R, Graham S, Fearon P, Tough S, Madigan S. The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5. Depression And Anxiety 2020, 37: 576-586. PMID: 32419282, DOI: 10.1002/da.23039.Peer-Reviewed Original ResearchConceptsDepression/anxietyMaternal depressionAge 5Maternal anxietyLarge prospective pregnancy cohortMaternal anxiety/depressionMaternal mental health problemsAntenatal maternal depressionProspective pregnancy cohortMaternal mental healthMother-child pairsClinical screening toolAnxiety/depressionChild outcomesMental health problemsWeeks' gestationPregnancy cohortYear postpartumPostpartum periodNumber of exposuresChild development outcomesDepression symptomsHealth problemsPoor child outcomesScreening toolNeuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development
Nazzari S, Fearon P, Rice F, Ciceri F, Molteni M, Frigerio A. Neuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development. Developmental Psychobiology 2020, 62: 1100-1110. PMID: 32232990, DOI: 10.1002/dev.21967.Peer-Reviewed Original ResearchConceptsInfant cognitive developmentEarly cognitive developmentCognitive developmentAnxiety symptomsCognitive outcomesInfant cognitive outcomesMaternal depressiveC-reactive proteinCognitive development scoresMaternal stressHierarchical linear regressionInterleukin-6Maternal caregivingMaternal IQMaternal antenatal stressConcurrent anxietyAlpha-amylase concentrationsDiurnal cortisolSerum interleukin-6Healthy pregnant womenSalivary cortisolDevelopment scoresDepressive symptomsCurrent studyAntenatal exposure
2018
Attentional Control as a Predictor of Response to Psychological Treatment for Depression and Relapse up to 1 year After Treatment: A Pilot Cohort Study
Buckman J, Saunders R, Fearon P, Leibowitz J, Pilling S. Attentional Control as a Predictor of Response to Psychological Treatment for Depression and Relapse up to 1 year After Treatment: A Pilot Cohort Study. Behavioural And Cognitive Psychotherapy 2018, 47: 318-331. PMID: 30352633, PMCID: PMC6372070, DOI: 10.1017/s1352465818000590.Peer-Reviewed Original ResearchConceptsAttentional Control ScaleAttentional controlSelf-report measuresBrief self-report measurePsychological treatment servicesDepressive symptomsDepressed patientsResidual depressive symptomsPsychological treatmentIAPT servicesACS scoreSymptom measuresControl ScaleTherapy sessionsDepressive symptom severitySymptom severityLittle varianceObserved relapsesResidual symptomsDepressionSmall overall sample sizeTreatment servicesMeasuresTreatment outcomesOverall sample sizeNetworks of Depression and Anxiety Symptoms Across Development
McElroy E, Fearon P, Belsky J, Fonagy P, Patalay P. Networks of Depression and Anxiety Symptoms Across Development. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 964-973. PMID: 30522742, PMCID: PMC6290121, DOI: 10.1016/j.jaac.2018.05.027.Peer-Reviewed Original ResearchConceptsAnxiety symptomsEarly childhoodSymptom-symptom associationsBidirectional longitudinal associationsSpecific symptomsChild healthHuman Development StudySymptomsMaternal reportsLongitudinal associationsNetwork of depressionTime pointsStrong associationDepressionAge 5National InstituteCentral symptomsNonparametric permutation testsLongitudinal investigationDiagnostic boundariesSymptom structureEarly Child CareAssociationPresent studyChildhoodRisk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis
Buckman J, Underwood A, Clarke K, Saunders R, Hollon S, Fearon P, Pilling S. Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis. Clinical Psychology Review 2018, 64: 13-38. PMID: 30075313, PMCID: PMC6237833, DOI: 10.1016/j.cpr.2018.07.005.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepressive Disorder, MajorHumansPrognosisRecurrenceRisk FactorsSecondary PreventionConceptsChildhood maltreatmentRecurrence of depressionModerate treatment responseMore enduring effectsMindfulness-based therapyCognitive diathesesCognitive controlAffective informationNeural mechanismsPsychological therapiesPsychosocial interventionsResidual symptomsEnduring effectPrescriptive indicesMaltreatmentFuture researchCausal pathwaysCausal mechanismsDepressionPrescriptive factorsLimbic pathwaysAdultsTreatment responseSymptomsConsequences
2016
Predicting treatment outcome in psychological treatment services by identifying latent profiles of patients
Saunders R, Cape J, Fearon P, Pilling S. Predicting treatment outcome in psychological treatment services by identifying latent profiles of patients. Journal Of Affective Disorders 2016, 197: 107-115. PMID: 26991365, DOI: 10.1016/j.jad.2016.03.011.Peer-Reviewed Original ResearchConceptsPsychological treatment servicesLatent profile analysisPsychological treatmentLatent profilesStandardized symptom measuresPsychological interventionsPsychological therapiesProfile analysisSymptom measuresSymptom domainsTreatment servicesTreatment outcomesSuitable interventionsLevel of attritionLongitudinal analysisBasic demographic informationInterventionDemographic informationAnxietyDifferent intensitiesTreatment responseOutcomesDepressionRoutine careDifferent groups
2013
Factorial invariance of the Patient Health Questionnaire and Generalized Anxiety Disorder Questionnaire
Ryan T, Bailey A, Fearon P, King J. Factorial invariance of the Patient Health Questionnaire and Generalized Anxiety Disorder Questionnaire. British Journal Of Clinical Psychology 2013, 52: 438-449. PMID: 24117915, PMCID: PMC4296344, DOI: 10.1111/bjc.12028.Peer-Reviewed Original ResearchConceptsGAD-7PHQ-9Patient Health Questionnaire depression scalePatient Health QuestionnaireGeneralized Anxiety Disorder QuestionnaireGeneralized Anxiety Disorder ScalePHQ-9 dataAnxiety Disorder QuestionnaireAnxiety Disorder ScaleConvergent validityPsychological Therapies (IAPT) programmePatient's symptomsHealth QuestionnaireDepression ScaleDisorder QuestionnaireIAPT servicesTherapy programScale's convergent validityAbstractTextEquivalent factor loadingsDisorder ScalePositive associationSymptomsFactor loadingsUnidimensional factor structure