2024
Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapy
2017
Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress
Barry T, Murray L, Fearon P, Moutsiana C, Johnstone T, Halligan S. Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress. Psychoneuroendocrinology 2017, 85: 96-99. PMID: 28843903, PMCID: PMC5632999, DOI: 10.1016/j.psyneuen.2017.07.487.Peer-Reviewed Original ResearchConceptsAmygdala volumePostnatal depressionMaternal postnatal depressionTotal amygdala volumeCortisol reactivityAdrenal (HPA) axis reactivityLower cortisol reactivityAdrenal axisCortisol secretionControl offspringAxis reactivityYoung adultsAmygdalaEarly adversityStress reactivitySocial stressSocial stressorsPresent studyEmotional processingEmotional pathologyOffspringCentral rolePathologyHierarchical linear modellingBrain
2014
Insecure attachment during infancy predicts greater amygdala volumes in early adulthood
Moutsiana C, Johnstone T, Murray L, Fearon P, Cooper P, Pliatsikas C, Goodyer I, Halligan S. Insecure attachment during infancy predicts greater amygdala volumes in early adulthood. Journal Of Child Psychology And Psychiatry 2014, 56: 540-548. PMID: 25156392, PMCID: PMC4407912, DOI: 10.1111/jcpp.12317.Peer-Reviewed Original ResearchConceptsAmygdala volumeGreater amygdala volumesMaternal postnatal depressionLarger amygdala volumesInfant attachment statusProspective longitudinal studyLongitudinal studyMonths of ageMaternal depression historyAmygdala morphologyMRI assessmentHippocampal volumePostnatal depressionAdult brainDepression historyNeural changesEarly environmentEarly caregiving environmentAttachment statusVolumetric differencesYoung adultsEarly adulthoodNeural areasCaregiving environmentCommon variation
2011
Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age
Murray L, Arteche A, Fearon P, Halligan S, Goodyer I, Cooper P. Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 50: 460-470. PMID: 21515195, DOI: 10.1016/j.jaac.2011.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild of Impaired ParentsChild, PreschoolDepression, PostpartumDepressive Disorder, MajorDysthymic DisorderFamily ConflictFemaleHumansInfantInterview, PsychologicalLife Change EventsLongitudinal StudiesMaleMass ScreeningObject AttachmentProspective StudiesResilience, PsychologicalRisk FactorsSocial SupportConceptsYears of ageDepressed mothersPostnatal depressionClinical depressionAdolescent depressionFamily adversityMain study outcomeMaternal postnatal depressionDevelopment of depressionProspective longitudinal studyDevelopmental risk pathwayIndex mothersOffspring riskProbable casesNondepressed mothersStudy outcomesChild vulnerabilityInsecure infant attachmentDepressionMothersLongitudinal studyRisk pathwaysFamily assessmentDevelopmental riskRisk
2010
The effects of maternal postnatal depression and child sex on academic performance at age 16 years: a developmental approach
Murray L, Arteche A, Fearon P, Halligan S, Croudace T, Cooper P. The effects of maternal postnatal depression and child sex on academic performance at age 16 years: a developmental approach. Journal Of Child Psychology And Psychiatry 2010, 51: 1150-1159. PMID: 20840504, DOI: 10.1111/j.1469-7610.2010.02259.x.Peer-Reviewed Original ResearchConceptsCognitive functioningMother-child interactionStructural equation modellingPostnatal depressionChild sexChildren's cognitive functioningMaternal depressionPoor cognitive functioningEarly school yearsNon-depressed mothersCognitive developmentMaternal postnatal depressionPND mothersAcademic outcomesDevelopmental approachMaternal interactionAcademic performanceGCSE performanceEquation modellingControl childrenSchool yearFunctioningEarly interventionExam performanceAge 16 years