2024
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildGyrus CinguliHumansMagnetic Resonance ImagingMental DisordersMental HealthNeural PathwaysConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainBrain MappingChildChild AbuseGyrus CinguliHumansMagnetic Resonance ImagingConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMental HealthRewardConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2021
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing.
Puetz V, Viding E, Maguire E, Mechelli A, Armbruster-Genç D, Sharp M, Rankin G, Gerin M, McCrory E. Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing. Development And Psychopathology 2021, 35: 1382-1389. PMID: 34924093, DOI: 10.1017/s0954579421001292.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildHumansMagnetic Resonance ImagingMemory, EpisodicMental RecallNeuronal PlasticityConceptsChildhood maltreatmentAutobiographical memory processingCortical midline structuresValenced cue wordsPotential developmental plasticityCue wordsMemory processingFMRI studyBOLD signal changesNeural functioningPsychological assessmentBrain networksMaltreatmentMidline structuresMaturational changesLongitudinal analysisProcessingSignal changesFMRIPsychopathologyRecallAdolescentsFunctioningWordsDevelopmental plasticity
2020
Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys
Pluess M, De Brito S, Bartoli A, McCrory E, Viding E. Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys. Development And Psychopathology 2020, 34: 901-910. PMID: 33342453, DOI: 10.1017/s0954579420001698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainChildHippocampusHumansIndividualityMagnetic Resonance ImagingMaleConceptsIndividual differencesLeft amygdalaEnvironmental influencesLeft amygdala volumeNeurobiological sensitivityImportant brain regionsChild behaviorBrain regionsEarly environmentContextual factorsPositive experiencesBrain structuresAmygdala volumePreliminary evidenceAmygdalaGeneral environmental qualityHippocampus volumeExploratory analysisBoysExploratory studyEnvironmental features
2019
Investigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdult Survivors of Child AbuseAmygdalaChild AbuseCuesFacial RecognitionFemaleHumansMagnetic Resonance ImagingMalePropensity ScoreStress, PsychologicalYoung AdultConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdalaHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment status
2018
A transdiagnostic neuroanatomical signature of psychiatric illness
Gong Q, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vieira S, McCrory E, Ai Y, Yang C, Zhang F, Lui S, Mechelli A. A transdiagnostic neuroanatomical signature of psychiatric illness. Neuropsychopharmacology 2018, 44: 869-875. PMID: 30127342, PMCID: PMC6461829, DOI: 10.1038/s41386-018-0175-9.Peer-Reviewed Original ResearchConceptsHealthy controlsPsychiatric illnessFamilial vulnerabilityUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGray matter volumeGreater gray matter volumePost-traumatic stress disorderStructural magnetic resonanceDifferent diagnostic categoriesFamily-wise error correctionPutamen enlargementObsessive-compulsive disorderPsychiatric diagnosisMatter volumePutamen volumePsychiatric groupsGeneral psychopathologyNeuroanatomical signatureUnaffected relativesStress disorderTransdiagnostic alterationsDiagnostic categoriesMental healthEvidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History
Hoffmann F, Viding E, Puetz V, Gerin M, Sethi A, Rankin G, McCrory E. Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 687-695.e4. PMID: 30196872, DOI: 10.1016/j.jaac.2018.05.020.Peer-Reviewed Original ResearchPrimary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms
Sethi A, McCrory E, Puetz V, Hoffmann F, Knodt A, Radtke S, Brigidi B, Hariri A, Viding E. Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 1013-1021. PMID: 29752216, PMCID: PMC6185817, DOI: 10.1016/j.bpsc.2018.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainEmotionsEmpathyFearFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePhotic StimulationVolunteersYoung AdultConceptsAnterior cingulate cortexNeurocognitive mechanismsPsychopathic traitsPrimary psychopathySecondary psychopathyCingulate cortexEmotional face processing taskComparison groupDifferent neurocognitive mechanismsDistinct neural correlatesFace processing taskFunctional magnetic resonance imagingInferior parietal lobeVolunteer sampleAnger processingNeurocognitive correlatesInsula activityNeural correlatesNeural responsesAnxiety measuresNeural activationSecondary presentationLower anxietyPsychopathy groupHigh anxietyAn fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
Sethi A, O'Nions E, McCrory E, Bird G, Viding E. An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits. NeuroImage Clinical 2018, 18: 298-304. PMID: 29876250, PMCID: PMC5987797, DOI: 10.1016/j.nicl.2018.01.027.Peer-Reviewed Original ResearchConceptsCP/HCUMedial prefrontal cortexCallous-unemotional traitsConduct problemsOwn emotionsAnterior cingulate cortexAnterior insulaEmpathic processingAffective experienceConjunction analysisACC/medial prefrontal cortexBrain areasBayes factor analysisEmpathy deficitsFMRI investigationTD groupNeural responsesConjunction effectOne's feelingsLess empathyEmotionsPrefrontal cortexNeutral scenarioCingulate cortexOccipital cortex
2017
A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin M, Puetz V, Blair R, White S, Sethi A, Hoffmann F, Palmer A, Viding E, McCrory E. A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children. Development And Psychopathology 2017, 29: 1689-1705. PMID: 29162176, DOI: 10.1017/s095457941700133x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildChild AbuseDecision MakingFemaleHumansMagnetic Resonance ImagingMaleReinforcement, PsychologyConceptsMaltreated groupReinforcement-based decisionEarly adverse environmentsFunctional magnetic resonanceSuperior temporal gyrusMedial temporal structuresPassive avoidance taskMiddle cingulate gyrusNegative cuesReinforcement expectanciesMaltreated childrenPsychosocial functioningTemporal gyrusPrediction errorVulnerability mechanismsAvoidance taskNonmaltreated peersOrbitofrontal cortexLatent vulnerabilityChildhood abuseWidespread networkValue processingPsychiatric vulnerabilityValue representationCingulate gyrusRisk-taking, peer-influence and child maltreatment: A neurocognitive investigation
Hoffmann F, Puetz V, Viding E, Sethi A, Palmer A, McCrory E. Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive And Affective Neuroscience 2017, 13: nsx124-. PMID: 29069467, PMCID: PMC5793726, DOI: 10.1093/scan/nsx124.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyCerebral CortexChildChild AbuseFemaleHumansMagnetic Resonance ImagingMalePeer InfluencePsychopathologyRisk FactorsRisk-TakingVentral StriatumConceptsRight anterior insulaMT groupBalloon Analogue Risk TaskMore anxiety symptomsPsychiatric disordersAnterior insulaFuture psychopathologyAnxiety symptomsChildrenDifferential effectsNeural correlatesNeurocognitive investigationsRisk-taking behaviorPeer influenceChild maltreatmentRiskGroupNeural levelMaltreatmentRisk TaskSymptomsInsulaModulation of amygdala response to task-irrelevant emotion
Sebastian C, McCrory E, De Brito S, Viding E. Modulation of amygdala response to task-irrelevant emotion. Social Cognitive And Affective Neuroscience 2017, 12: 643-650. PMID: 28119506, PMCID: PMC5390695, DOI: 10.1093/scan/nsw174.Peer-Reviewed Original ResearchConceptsAmygdala responseTask demandsPerceptual inputTask performanceConflict conditionsTask-irrelevant emotional stimuliTask-irrelevant emotionFearful facial expressionsCognitive conflict tasksCognitive task performanceSlower reaction timesHigh-conflict conditionPsychophysiological interaction analysisRight amygdala responseLow-conflict conditionsMiddle frontal gyrusFunctional couplingEmotion regulationExecutive demandsEmotional informationConflict taskEmotional stimuliCognitive conflictCognitive demandsEmotional context
2016
Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits
Seara-Cardoso A, Sebastian C, McCrory E, Foulkes L, Buon M, Roiser J, Viding E. Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits. Scientific Reports 2016, 6: 36273. PMID: 27808160, PMCID: PMC5093734, DOI: 10.1038/srep36273.Peer-Reviewed Original ResearchConceptsAnticipation of guiltEveryday moral transgressionsPsychopathic traitsAnterior insulaMoral transgressionsInterpersonal psychopathic traitsPattern of findingsNeurocognitive mechanismsMotivational processingMoral emotionsNeural responsesAntisocial behaviorMoral behaviorSocial normsGuiltInsulaPersonality disorderSecond sampleAnticipationHigh levelsSignificant interactionWrongnessTransgressionEmotionsTraitsRegional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms
Cohn M, Viding E, McCrory E, Pape L, van den Brink W, Doreleijers T, Veltman D, Popma A. Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms. Psychiatry Research Neuroimaging 2016, 254: 180-187. PMID: 27479922, DOI: 10.1016/j.pscychresns.2016.07.003.Peer-Reviewed Original ResearchThe sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification
Kelly P, Viding E, Puetz V, Palmer A, Samuel S, McCrory E. The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification. Journal Of Neural Transmission 2016, 123: 1069-1083. PMID: 26922372, PMCID: PMC5003912, DOI: 10.1007/s00702-016-1523-8.Peer-Reviewed Original ResearchConceptsCortical thicknessLocal gyrificationCortical structuresParietal cortexRight inferior parietal cortexRight anterior cingulateLeft precentral gyrusSuperior frontal gyrusInferior parietal cortexSuperior parietal cortexPrecentral gyrusBrain areasAnterior cingulateDimorphic impactMaltreatment experiencesOrbitofrontal cortexBrain structuresLarge community sampleMaltreatment exposureFrontal gyrusGyrificationCortexSex influenceAtypical patternsCommunity sample
2015
Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
Sebastian C, De Brito S, McCrory E, Hyde Z, Lockwood P, Cecil C, Viding E. Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits. Research On Child And Adolescent Psychopathology 2015, 44: 639-649. PMID: 26364620, PMCID: PMC4830891, DOI: 10.1007/s10802-015-0073-0.Peer-Reviewed Original ResearchChildhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents
Elsey J, Coates A, Lacadie CM, McCrory EJ, Sinha R, Mayes LC, Potenza MN. Childhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents. Neuropsychopharmacology 2015, 40: 1580-1589. PMID: 25567424, PMCID: PMC4915266, DOI: 10.1038/npp.2015.6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChild AbuseCuesEmotionsFemaleFood PreferencesHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleOxygenStress, PsychologicalConceptsChildhood traumaPersonalized stressSubjective anxietyFavorite-food cuesFunctional magnetic resonance imagingPhysical health outcomesCortico-limbic circuitryNeural correlatesMotivational stateTrauma exposureNeural responsesFunctional neuroimagingPrefrontal cortexStress cuesAnterior cingulateEmotional disturbanceCerebellar regionsCuesGroup differencesRisky behaviorsBrain regionsAdolescentsSubcortical structuresAnxietyIncreased activation
2014
Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits
O'Nions E, Sebastian C, McCrory E, Chantiluke K, Happé F, Viding E. Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits. Developmental Science 2014, 17: 786-796. PMID: 24636205, PMCID: PMC4316185, DOI: 10.1111/desc.12167.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleCP/HCUASD groupTemporoparietal junctionConduct problemsSpectrum disorderMedial prefrontal cortex responsesAtypical neural processingRight temporoparietal junctionPrefrontal cortex responsesCallous-unemotional traitsMedial prefrontal cortexAtypical processingToM processingVignette taskNeural levelNeural underpinningsNeural basisTD controlsNeural processingSocial difficultiesNeural responsesObservation ScheduleFMRI responses