2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainBrain MappingChildChild AbuseGyrus CinguliHumansMagnetic Resonance ImagingConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory E, Foulkes L, Viding E. Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability. The Lancet Psychiatry 2022, 9: 828-837. PMID: 35926524, DOI: 10.1016/s2215-0366(22)00202-4.Peer-Reviewed Original ResearchConceptsTransactional modelChildhood maltreatmentNeurocognitive alterationsPsychiatric disordersQuantity of relationshipsIndividual's social networkSocial functioningSocial architecturePsychiatric vulnerabilityMaltreatmentSocial environmentExtant evidencePsychiatric riskNeurocognitive sequelaeSocial processesStress generationSocial networksDisordersAltered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2021
Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces
Neil L, Viding E, Armbruster‐Genc D, Lisi M, Mareschal I, Rankin G, Sharp M, Phillips H, Rapley J, Martin P, McCrory E. Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces. Journal Of Child Psychology And Psychiatry 2021, 63: 655-662. PMID: 34500497, DOI: 10.1111/jcpp.13503.Peer-Reviewed Original ResearchConceptsTrust processingUnfamiliar facesChildhood maltreatmentPoor social functioningMental health difficultiesMental health problemsFacial stimuliCognitive abilitiesTrust judgmentsTrust attributionTrustworthiness dimensionsCommunity-based sampleSocial service recordsSocial functioningMaltreatment experiencesHealth difficultiesChild maltreatmentMaltreatmentSocial bondsAtypical patternsPeersEvidence of biasChildrenSocioeconomic statusProcessingChild Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization
Goemans A, Viding E, McCrory E. Child Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization. Trauma Violence & Abuse 2021, 24: 530-548. PMID: 34355601, PMCID: PMC10009486, DOI: 10.1177/15248380211036393.Peer-Reviewed Original ResearchConceptsMental healthMental health careMental health outcomesAdverse childhood experiencesMental health vulnerabilitiesSystematic scoping reviewInpatient populationChild maltreatmentHealth outcomesGoogle ScholarHealth careNeurocognitive functioningPutative mechanismsRisk of revictimizationScoping ReviewHealth vulnerabilityChildrenNeurocognitive findingsPreventative modelAdditive effectChildhood experiencesRiskPeer victimizationHealthMaltreatment
2019
Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity
Thompson-Booth C, Viding E, Puetz VB, Rutherford HJV, Mayes LC, McCrory EJ. Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity. Emotion 2019, 19: 1093-1102. PMID: 30234333, DOI: 10.1037/emo0000464.Peer-Reviewed Original ResearchConceptsInfant facesChildhood maltreatmentAttentional processingDyadic reciprocityLower attentional biasVisual search taskAttentional biasEmotional cuesCognitive processingPreferential processingInfant affectParenting behaviorsInfant cuesSearch taskAn Experimental InvestigationCommunity sampleMaltreatment experiencesMaltreatmentPreferential biasOwn childrenCuesExploratory analysisProcessingFaceImportant implicationsInvestigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdalaHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment statusEvidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence
González R, Vélez-Pastrana M, McCrory E, Kallis C, Aguila J, Canino G, Bird H. Evidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 671-682. PMID: 30903235, DOI: 10.1007/s00127-019-01659-0.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD diagnosisEarly maltreatmentFoster placementPhysical abuseADHD medication statusRole of maltreatmentLongitudinal studyProspective associationsLikelihood of ADHDPuerto Rican backgroundHyperactivity disorderChildren-IVBoricua Youth StudyParental psychopathologyFamily environmentMaltreatment experiencesEmotional abuseMaltreatment exposureRisk of ADHDSexual abuseDisorder persistenceChildhood maltreatmentDiagnostic Interview ScheduleInitial evidence
2018
Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History
Hoffmann F, Viding E, Puetz V, Gerin M, Sethi A, Rankin G, McCrory E. Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 687-695.e4. PMID: 30196872, DOI: 10.1016/j.jaac.2018.05.020.Peer-Reviewed Original Research
2017
Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group
Cecil C, McCrory E, Barker E, Guiney J, Viding E. Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group. European Child & Adolescent Psychiatry 2017, 27: 885-898. PMID: 29222633, PMCID: PMC6013514, DOI: 10.1007/s00787-017-1086-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxiety DisordersChild AbuseEmotionsFemaleHumansMalePsychopathologyYoung AdultConceptsCallous-unemotional traitsTrauma historyHigh callous-unemotional traitsCo-occurring anxietyGreater attachment insecurityLevels of irritabilityHigh-risk youthSevere childhood maltreatmentAttachment insecurityADHD symptomatologyAttachment styleAffective functioningCU traitsPsychological distressAntisocial behaviorCommunity sampleAffective dysregulationHigh anxietyChildhood maltreatmentConcurrent anxietyClinical groupsSubstance useAnxietyPsychiatric symptomatologyYouthA neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin M, Puetz V, Blair R, White S, Sethi A, Hoffmann F, Palmer A, Viding E, McCrory E. A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children. Development And Psychopathology 2017, 29: 1689-1705. PMID: 29162176, DOI: 10.1017/s095457941700133x.Peer-Reviewed Original ResearchConceptsMaltreated groupReinforcement-based decisionEarly adverse environmentsFunctional magnetic resonanceSuperior temporal gyrusMedial temporal structuresPassive avoidance taskMiddle cingulate gyrusNegative cuesReinforcement expectanciesMaltreated childrenPsychosocial functioningTemporal gyrusPrediction errorVulnerability mechanismsAvoidance taskNonmaltreated peersOrbitofrontal cortexLatent vulnerabilityChildhood abuseWidespread networkValue processingPsychiatric vulnerabilityValue representationCingulate gyrusRisk-taking, peer-influence and child maltreatment: A neurocognitive investigation
Hoffmann F, Puetz V, Viding E, Sethi A, Palmer A, McCrory E. Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive And Affective Neuroscience 2017, 13: nsx124-. PMID: 29069467, PMCID: PMC5793726, DOI: 10.1093/scan/nsx124.Peer-Reviewed Original ResearchConceptsRight anterior insulaMT groupBalloon Analogue Risk TaskMore anxiety symptomsPsychiatric disordersAnterior insulaFuture psychopathologyAnxiety symptomsChildrenDifferential effectsNeural correlatesNeurocognitive investigationsRisk-taking behaviorPeer influenceChild maltreatmentRiskGroupNeural levelMaltreatmentRisk TaskSymptomsInsulaAnnual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory E, Gerin M, Viding E. Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging. Journal Of Child Psychology And Psychiatry 2017, 58: 338-357. PMID: 28295339, PMCID: PMC6849838, DOI: 10.1111/jcpp.12713.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexLatent vulnerabilityEmotion regulationThreat processingReward processingChildhood maltreatmentActive emotion regulationDorsal ACC activityReceipt of rewardAdverse caregiving environmentsFuture psychiatric disordersPsychiatric disordersFunctional brain imagingEffective preventative approachesEffortful processingExecutive controlStudy of childrenError monitoringPoor mental healthNeurocognitive domainsNeurocognitive functioningCaregiving environmentNeural responsesEarly neglectNeural responsiveness
2016
Disentangling the mental health impact of childhood abuse and neglect
Cecil C, Viding E, Fearon P, Glaser D, McCrory E. Disentangling the mental health impact of childhood abuse and neglect. Child Abuse & Neglect 2016, 63: 106-119. PMID: 27914236, DOI: 10.1016/j.chiabu.2016.11.024.Peer-Reviewed Original ResearchConceptsMental healthMaltreatment typesMain independent predictorsMental health impactMental health outcomesCommunity violence exposureIndependent predictorsTrauma-related symptomsOutcome measuresPsychiatric symptomsHigh-risk youthHealth outcomesPsychiatric symptomatologySocio-demographic variablesSymptom severityNeighbourhood deprivationViolence exposureChildhood abuseHealth impactsCommunity sampleSymptomsIndividual responsesSpecific effectsCurrent studyEmotional abuseEpigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability
Cecil C, Smith R, Walton E, Mill J, McCrory E, Viding E. Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. Journal Of Psychiatric Research 2016, 83: 184-194. PMID: 27643477, DOI: 10.1016/j.jpsychires.2016.09.010.Peer-Reviewed Original ResearchConceptsEpigenetic signaturesDNA methylationBiological processesMethylomic variationUnique epigenetic signatureGene ontology analysisSpecific biological processesHigh-confidence associationsUnique methylation patternOrganismal growthOntology analysisEpigenetic processesMethylation patternsMolecular linkEpithelial cell samplesNeural developmentNovel insightsNovel potential biomarkersMethylationCell samplesStringent setPotential pathwaysGenomePotential biomarkersBuccal epithelial cell samplesThe sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification
Kelly P, Viding E, Puetz V, Palmer A, Samuel S, McCrory E. The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification. Journal Of Neural Transmission 2016, 123: 1069-1083. PMID: 26922372, PMCID: PMC5003912, DOI: 10.1007/s00702-016-1523-8.Peer-Reviewed Original ResearchConceptsCortical thicknessLocal gyrificationCortical structuresParietal cortexRight inferior parietal cortexRight anterior cingulateLeft precentral gyrusSuperior frontal gyrusInferior parietal cortexSuperior parietal cortexPrecentral gyrusBrain areasAnterior cingulateDimorphic impactMaltreatment experiencesOrbitofrontal cortexBrain structuresLarge community sampleMaltreatment exposureFrontal gyrusGyrificationCortexSex influenceAtypical patternsCommunity sample
2015
Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation
Kelly P, Viding E, Puetz V, Palmer A, Mechelli A, Pingault J, Samuel S, McCrory E. Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation. Development And Psychopathology 2015, 27: 1591-1609. PMID: 26535946, DOI: 10.1017/s0954579415000966.Peer-Reviewed Original ResearchConceptsGray matter volumeAttentional avoidanceEmotional functioningSupramarginal gyrusVisual dot-probe taskMatter volumeSex differencesDot-probe taskBilateral supramarginal gyrusLarge community sampleMedial orbitofrontal cortexOrbitofrontal cortex gray matter volumeAttentional biasMiddle temporal lobePeer functioningThreat processingSocioemotional functioningEmotional reactivityNeural basisMaltreated groupMaltreated childrenMultilevel investigationCommunity sampleNonmaltreated peersOrbitofrontal cortexInitial Validation of a Brief Pictorial Measure of Caregiver Aggression
Cecil C, McCrory E, Viding E, Holden G, Barker E. Initial Validation of a Brief Pictorial Measure of Caregiver Aggression. Assessment 2015, 23: 307-320. PMID: 26085494, DOI: 10.1177/1073191115587552.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireScreening toolTrauma QuestionnaireCurrent psychiatric symptomsPsychometric propertiesPsychiatric symptomsSelf-report toolHigh-risk youthInitial psychometric propertiesPsychiatric symptomatologyIntimate partner violenceConvergent validityInternal consistencyMaltreatment historyPresent studyDiscriminative associationsPartner violenceMulti-informant reportsQuestionnaireInitial findingsSymptomsInitial validationSymptomatologyThe theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder
McCrory E, Viding E. The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder. Development And Psychopathology 2015, 27: 493-505. PMID: 25997767, DOI: 10.1017/s0954579415000115.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMental health problemsLatent vulnerabilityPsychiatric riskHealth problemsClinical interventionsDisordersNeurocognitive domainsPrevention approachesChildhood maltreatmentIntervention opportunitiesRisk trajectoriesPsychiatry approachMemory processingInterventionThreat processingChildrenRiskVulnerable childrenMaltreatmentLong termLife spanRisk environmentMaltreating environment