2024
Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical featuresA Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505)
Poppe M, Le-Rademacher J, Haffty B, Hansen E, Agarwal J, Wagner J, Kong I, Armer J, Arthur D, Whelan T, Lee M, Kour O, Lustberg M, Partridge A, Carey L, Ruddy K, Gaffney D, Stecklein S, Bernstein M, Khan A. A Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s11. DOI: 10.1016/j.ijrobp.2024.07.002.Peer-Reviewed Original ResearchPost-mastectomy radiation therapyNeoadjuvant chemotherapyBreast reconstructionComplication rateReconstruction complicationsBreast cancerNon-inferiorityHigh-risk breast cancerBody mass index >Conventionally fractionated radiationGenetic predisposition genesImplant-only reconstructionsMedian follow-upImmediate breast reconstructionOne-sided type I errorNon-inferiority marginStandard of careHypofractionated radiationRegional recurrenceRadiation therapyTumor characteristicsInvasive BCAdjuvant chemotherapyPredisposition genesMedian ageFirst Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients
Yehia Z, Sherwani Z, Chakraborty M, Ohri N, Grann A, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Blackwood M, Toppmeyer D, Haffty B. First Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024 PMID: 39241809, DOI: 10.1016/j.ijrobp.2024.08.043.Peer-Reviewed Original ResearchWhole breast RTBreast-conserving therapyBoost volumePostoperative RTRT boostPrimary outcomeBreast RTRadiation therapyCosmetic outcomeWound complicationsBreast cancerClinically node-negative breast cancerPhase II prospective clinical trialMedian clinical tumor sizePostoperative whole-breast RTProspective phase 2 trialIncidence of grade 3Node-negative breast cancerProspective phase 2 studyRate of postoperative wound complicationsDuctal carcinoma in situClinical tumor sizeCarcinoma in situPhase 2 studyPhase 2 trialRadiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives
Kim J, Fahmy V, Haffty B. Radiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives. Expert Review Of Anticancer Therapy 2024, 24: 211-217. PMID: 38502143, DOI: 10.1080/14737140.2024.2333320.Peer-Reviewed Original ResearchTriple-negative breast cancerPoly (ADP-ribose) polymeraseLocoregional controlRadiation therapyBreast cancerImpact of post-mastectomy radiation therapyPost-mastectomy radiation therapyEffects of radiotherapySynergistic effects of radiotherapyPersonalized treatment approachesImproved survival ratesIntegration of radiomicsImmunotherapy combinationsBRCA1/2 mutationsRadiotherapy responseOvercome radioresistanceTargeted radiosensitizationImprove patient outcomesRadiosensitizing strategiesNovel radiosensitizersTarget biological pathwaysTreatment strategiesTreatment outcomesMolecular profilingRadiotherapy
2010
Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT).
Goswami J, Goyal S, Wu H, Moran M, Haffty B. Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT). Journal Of Clinical Oncology 2010, 28: 582-582. DOI: 10.1200/jco.2010.28.15_suppl.582.Peer-Reviewed Original Research