MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model. Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R.J Clin Invest. 2021 Dec 1;131(23): e127171. doi: 10.1172/JCI127171.PMID: 34850744
Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria. Baeza Garcia A, Siu E, Du X, Leng L, Franke-Fayard B, Janse CJ, Howland SW, Rénia L, Lolis E, Bucala R.FASEB J. 2021 Dec;35(12): e21997. doi: 10.1096/fj.202101072R.PMID: 34719814
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease. Nakamura A, Zeng F, Nakamura S, Reid KT, Gracey E, Lim M, Leng L, Jo S, Park YS, Kusuda M, Machhar R, Boroojeni SF, Wu B, Rossomacha E, Kim TH, Ciccia F, Rockel JS, Kapoor M, Inman RD, Jurisica I, Crome SQ, Bucala R, Haroon N. Sci Transl Med. 2021 Oct 20;13(616): eabg1210.
ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus.Yao J, Leng L, Fu W, Li J, Bronner C, Bucala R. Arthritis Rheumatol. 2021 Oct;73(10):1931-1942. doi: 10.1002/art.41753. Epub 2021 Sep 3. PMID: 33844457
Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain.Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Menard RE, Hunt DE, Leng L, Bucala R, Vera PL. PLoS One. 2021 Aug 23;16(8): e0255975. doi: 10.1371/journal.pone.0255975. eCollection 2021.PMID: 34424927
Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis. Poulsen KL, Fan X, Kibler CD, Huang E, Wu X, McMullen MR, Leng L, Bucala R, Ventura-Cots M, Argemi J, Bataller R, Nagy LE. JCI Insight. 2021 Jun 8;6(11): e141420. doi: 10.1172/jci.insight.141420.PMID: 33945507
Neoantigen driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cui C, Wang J, Fagerberg E, Chen P-M, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H., J. Craft*, Joshi NS*. Cell 2021 Nov 22;S0092-8674(21)01322-2. doi: 10.1016/j.cell.2021.11.007. *co-senior authors.
Case Report: Elevated Inflammatory Markers & A Hypermetabolic Mass. Lisa L. Korn, MD, PhD, Mina L. Xu, MD, & Cristina Brunet, MD, Korn, L., Xu, L., Brunet, C. The Rheumatologist. 2021 Dec; 15(12):68-69.
Identification of Hospitals That Care for a High Proportion of Patients with Social Risk Factors. Matty R, Heckmann R, George E, Barthel AB, Suter LG, Ross JS, Bernheim SM. JAMA Health Forum 2021;2(7):e211323.
Socioeconomic Disparities in Functional Status in a National Sample of Patients with Rheumatoid Arthritis. Izadi Z, Li J, Evans M, Hammam N, Katz P, Ogdie A, Suter LG, Yazdany J, Schmajuk G. JAMA Network Open. 2021 Aug 2;4(8):e2119400. PMID: 34347058
Global Rheumatology Research: Frontiers, Challenges, and Opportunities Joshua B Bilsborrow, Ingris Peláez-Ballestas, Bernardo Pons-Estel, Christiaan Scott, Xinping Tian, Graciela S Alarcon, Richard Bucala, Laura B Lewandowski, Evelyn Hsieh Arthritis Rheumatol. 2022 Jan;74(1):1-4. doi: 10.1002/art.41980. Epub 2021 Dec 8.
Single-Cell Multi-Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19.Unterman A, Sumida T, Nouri N, Yan X, Zhao A, Gasque V, Schupp JC, Asashima H, Liu J, Cosme Jr. C, Deng W, Chen M, Raredon S, Hoehn KB, Wang G, Wang Z, Deluliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier JG, Bermejo S, Sharma L, Casanovas-Massana A, Vogels C, Wyllie A, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian S, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Comm 2022; 13:440.
Immunophenotyping Assessment of a Coronavirus Cohort (IMPACC): A Multisite Longitudinal Study of Hospitalized COVID-19 Patients. Rouphael N, Maecker H, Montgomery RR, Diray-Arce J, Kleinstein SH, Altman MC, Bosinger SE, Eckalbar W, Guan L, Hough C, Krammer F, Langelier C, Levy O, McEnaney K, Peters B, Rahman A, Sigelman S, Steen H, van Bakel H, Ward A, Wilson M, Woodruff P, Augustine AD, Ozonoff A, Reed EF, Becker PM. Sci immunol; 6:eabf3733.
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. PLoS biology 2021; 19:e3001143.
Single Cell Immunophenotyping of Skin Lesion Erythema Migrans Identifies IgM Memory B Cells. Jiang RD, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. JCI Insight 2021; 6:e148035.
The Section of Rheumatology, Allergy and Immunology is dedicated to providing care for patients with rheumatic, allergic and immunologic disorders; educating future generations of thought leaders in the field; and conducting research into fundamental questions of autoimmunity and immunology. To learn more about their work, visit Rheumatology, Allergy & Immunology.