2019
Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development
Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development. Methods In Molecular Biology 2019, 2011: 3-22. PMID: 31273690, PMCID: PMC6895673, DOI: 10.1007/978-1-4939-9554-7_1.Peer-Reviewed Original ResearchConceptsPreclinical researchAnimal modelsPsychiatric conditionsLower clinical success ratesClinical success rateCommon psychiatric conditionsPsychiatric clinical trialsClinical trialsNew pharmacotherapiesMore effective interventionsPreclinical workPsychiatric disordersPsychiatric pathophysiologyMental illnessSystematic reviewEffective interventionsAnimal experimentsDrug development processSuccess rateDrug developmentHuman psychopathologyPharmaceutical companiesPredictive validityLarge pharmaceutical companiesAnimals
2015
How Animal Models Inform Child and Adolescent Psychiatry
Stevens HE, Vaccarino FM. How Animal Models Inform Child and Adolescent Psychiatry. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 352-359. PMID: 25901771, PMCID: PMC4407022, DOI: 10.1016/j.jaac.2015.01.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRisk factorsPsychiatric disordersAnimal modelsImportance of doseChildhood psychiatric disordersAdolescent psychiatryAnimal model systemsAnimal model workChild psychiatryPsychiatric pathophysiologyBrain developmentChildhood disordersChild psychiatristsBrain functioningBasis of recoveryDisordersBehavioral problemsChildrenClinical workPsychiatryField of childPathophysiologyFactorsDoseNeurochemistry
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