BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis
Usmani M, Krattli R, El-Khatib S, Le A, Smith S, Baulch J, Ng D, Acharya M, Chan A. BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis. Neurotherapeutics 2023, 20: 838-852. PMID: 36720792, PMCID: PMC10275819, DOI: 10.1007/s13311-022-01339-z.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorCancer-related cognitive impairmentCognitive impairmentReduced anxiety-like behaviorDentate neurogenesisReduction of BDNF levelsBlood levels of brain-derived neurotrophic factorFear extinction memory consolidationLevels of brain-derived neurotrophic factorExtinction memory consolidationAnxiety-like behaviorBreast cancer patients treated with doxorubicinHippocampal-dependent learningCancer patients treated with doxorubicinPatients treated with doxorubicinADR-treated miceImpact of riluzoleChemotherapy-induced reductionPre-clinical evidenceMemory consolidationBDNF levelsMemory functionCognitive functionCognitive declineIncreased neuroinflammation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply