2019
Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents
Ghosal S, Duman CH, Liu RJ, Wu M, Terwilliger R, Girgenti MJ, Wohleb E, Fogaca MV, Teichman EM, Hare B, Duman RS. Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents. Neurobiology Of Disease 2019, 134: 104669. PMID: 31707118, DOI: 10.1016/j.nbd.2019.104669.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressMedial prefrontal cortexInhibitory post-synaptic currentsGABAergic transmissionSingle doseMale rodentsPrefrontal cortexImbalance of inhibitoryMPFC pyramidal neuronsDepressive-like behaviorDepression-like behaviorStress-induced impairmentModel of depressionPost-synaptic currentsPrecise cellular mechanismsGABAergic proteinsAntidepressant ketamineSynaptic deficitsGABAergic synapsesPyramidal neuronsSynaptic markersGABA markersGlutamate neurotransmissionDepressive behaviorGABA neurotransmission
2018
Profiling changes in cortical astroglial cells following chronic stress
Simard S, Coppola G, Rudyk CA, Hayley S, McQuaid RJ, Salmaso N. Profiling changes in cortical astroglial cells following chronic stress. Neuropsychopharmacology 2018, 43: 1961-1971. PMID: 29907879, PMCID: PMC6046043, DOI: 10.1038/s41386-018-0105-x.Peer-Reviewed Original ResearchConceptsChronic variable stressDepressive-like behaviorPerineuronal netsAstroglial cellsAstroglial plasticityCortical astroglial cellsAstroglial cell functionModel of depressionAstroglial contributionNeuroplasticity hypothesisAstroglial changesCortical astrogliaAntidepressant potentialDepressive behaviorSwim testGFAP expressionDepressive phenotypeNeuronal plasticityGlutamate recyclingCorticosterone levelsRibosome affinity purificationSynaptic plasticityGrowth factor signalingChronic stressDegradation of PNNs
2014
Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms
Amchova P, Kucerova J, Giugliano V, Babinska Z, Zanda M, Scherma M, Dusek L, Fadda P, Micale V, Sulcova A, Fratta W, Fattore L. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Frontiers In Pharmacology 2014, 5: 44. PMID: 24688470, PMCID: PMC3960502, DOI: 10.3389/fphar.2014.00044.Peer-Reviewed Original ResearchCB1 receptor agonist WIN55,212-2Model of depressionAgonist WIN55,212-2OBX ratsAcute pre-treatmentNucleus accumbensBulbectomized ratsSelf-AdministrationWIN55,212-2CGS 12066BIntravenous drug self-administration procedureRats self-administering methamphetamineDrug self-administration proceduresAnimal models of depressionSubstance Use Disorder ComorbidityAssociated with drug consumptionBrain reward functionEnhanced self-administrationSelf-administer WINSerotonin 5HT1B receptor agonistsSham-operated ratsSelf-administer methamphetamineSelf-administration proceduresDepressive-like ratsDepressive-like state
2010
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists. Science 2010, 329: 959-964. PMID: 20724638, PMCID: PMC3116441, DOI: 10.1126/science.1190287.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsDendritic SpinesDepressionIntracellular Signaling Peptides and ProteinsKetamineMaleNeuronsNeuropeptidesPhenolsPiperidinesProtein BiosynthesisProtein Serine-Threonine KinasesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSignal TransductionSirolimusSynapsesTime FactorsTOR Serine-Threonine KinasesConceptsTreatment-resistant depressed patientsBlockade of mTORFast antidepressant actionAction of ketamineRapid antidepressant effectsRapid antidepressant responseEffects of ketamineModel of depressionAntidepressant actionAntidepressant effectsAntidepressant responseKetamine inductionStandard medicationSynaptic deficitsKetamine administrationDepressed patientsSpine synapsesNMDA antagonistsMood disordersSynapse formationKetamineMammalian targetPrefrontal cortexRapamycin (mTOR) pathwayPossible new approach
2004
Romantic involvement and depressive symptoms in early and late adolescence: The role of a preoccupied relational style
Davila J, Steinberg S, Kachadourian L, Cobb R, Fincham F. Romantic involvement and depressive symptoms in early and late adolescence: The role of a preoccupied relational style. Personal Relationships 2004, 11: 161-178. DOI: 10.1111/j.1475-6811.2004.00076.x.Peer-Reviewed Original Research
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