2020
Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling
Y C, Marioni J, Griffiths G, Richard A. Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling. ELife 2020, 9: e53948. PMID: 32412411, PMCID: PMC7308083, DOI: 10.7554/elife.53948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCells, CulturedFemaleFlow CytometryInterferon Regulatory FactorsKineticsLigandsLymphocyte ActivationMaleMice, Inbred C57BLMice, TransgenicNuclear Receptor Subfamily 4, Group A, Member 1OvalbuminPeptide FragmentsPhosphorylationReceptors, Antigen, T-CellRibosomal Protein S6Signal TransductionSingle-Cell AnalysisConceptsT cellsMurine CD8<sup>+</sup> T cellsStrength of TCR stimulationCD8<sup>+</sup> T cellsDistal signaling eventsStimulation strengthTCR-induced signalsNaive T cellsMultiple signaling pathwaysT cell activationRibosomal protein S6Signaling eventsPeptide-MHC ligandsIntracellular machineryTCR stimulationProtein S6Signaling pathwayMass cytometrySignaling resultsStimulationMolecular organizationTranscription
2019
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells
Duarte RRR, Bachtel ND, Côtel MC, Lee SH, Selvackadunco S, Watson IA, Hovsepian GA, Troakes C, Breen GD, Nixon DF, Murray RM, Bray NJ, Eleftherianos I, Vernon AC, Powell TR, Srivastava DP. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Biological Psychiatry 2019, 86: 120-130. PMID: 31097295, PMCID: PMC6614717, DOI: 10.1016/j.biopsych.2019.03.977.Peer-Reviewed Original ResearchConceptsHuman neural progenitor cellsProtein translationNeural progenitor cellsMotility behaviorAvailable expression dataRibosomal protein S6Protein Kinase SignalingRegulation of AMPKProgenitor cellsNutrient sensing mechanismsProtein kinase alphaQuantitative polymerase chain reactionPsychiatric risk allelesDrosophila melanogasterTranscriptional changesKinase signalingProtein S6Transcriptomic profilingRNA interferenceNeural stem cellsExpression changesKinase alphaUnknown roleExpression dataHuman dorsolateral prefrontal cortex
2000
Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*
Martin K, Schalm S, Romanelli A, Keon K, Blenis J. Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*. Journal Of Biological Chemistry 2000, 276: 7892-7898. PMID: 11108720, DOI: 10.1074/jbc.m009972200.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCells, CulturedEnzyme ActivationEpidermal Growth FactorHumansIsoenzymesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesNitrilesPhosphatidylinositol 3-KinasesPhosphorylationRibosomal Protein S6 KinasesConceptsNuclear localization signalLocalization signalPhosphorylation sitesProtein kinaseMitogen-activated protein kinase phosphorylation siteC-terminal nuclear localization signalSerine/threonine protein kinaseProtein kinase phosphorylation siteSignal-regulated kinase kinaseRibosomal S6 kinase 2C-terminal phosphorylation sitesC-terminal repressor domainThreonine protein kinaseKinase phosphorylation siteC-terminal motifMitogen-activated protein kinasePhosphorylation site mutationsS6 kinase 2C-terminal domainKinase kinase inhibitor U0126Ribosomal protein S6C-terminal deletionsC-terminal regionKinase inhibitor U0126Site-specific mutationsRegulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*
Martin K, Schalm S, Richardson C, Romanelli A, Keon K, Blenis J. Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*. Journal Of Biological Chemistry 2000, 276: 7884-7891. PMID: 11108711, DOI: 10.1074/jbc.m006969200.Peer-Reviewed Original ResearchConceptsProtein kinase CzetaC-terminusPhosphoinositide-dependent kinase 1Ribosomal S6 kinase 2S6 kinase 2PI3K effectorsRibosomal S6 kinaseRibosomal protein S6Agonist-dependent activationS6 kinaseProtein S6Kinase activityKinase 2Kinase 1Translational capacityS6K2Terminal sequencePhysiological roleImportant regulatorRapamycin (mTOR) pathwayMammalian targetS6K1Basal activationTerminusHomolog
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