2024
POLYGENIC RISK SCORE FOR DIABETES PREDICTS POSTOPERATIVE ACUTE KIDNEY INJURY
Leis A, Mathis M, Smith J, Mukherjee B, Karvonen-Gutierrez C. POLYGENIC RISK SCORE FOR DIABETES PREDICTS POSTOPERATIVE ACUTE KIDNEY INJURY. Innovation In Aging 2024, 8: 132-133. PMCID: PMC11689292, DOI: 10.1093/geroni/igae098.0427.Peer-Reviewed Original ResearchPolygenic risk scoresAcute kidney injuryKidney Disease-Improving Global OutcomesOdds of acute kidney injuryPostoperative acute kidney injuryPredicting postoperative acute kidney injuryRisk scoreKidney injuryAcute kidney injury prevalenceLogistic regression modelsOlder adultsT2DM statusType 2 diabetesInformation biasPRS modelTransplant surgical proceduresAnalysis of outcomesGenetic cohortsDiabetes statusLowest decileIntraoperative factorsNon-cardiacNon-renalNon-urologicalSurgical proceduresBalancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study
Lei Y, Christian Naj A, Xu H, Li R, Chen Y. Balancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study. Journal Of Biomedical Informatics 2024, 157: 104705. PMID: 39134233, DOI: 10.1016/j.jbi.2024.104705.Peer-Reviewed Original ResearchAlzheimer's Disease Genetics ConsortiumChart reviewPRS modelCase-control datasetGenetic association analysisGenetics ConsortiumPhenotype misclassificationSimulated phenotypesPhenotypic dataAssociation analysisEstimation of associated parametersBias reduction methodMedian thresholdPhenotypeMisclassification rateOriginal phenotypeDiverse arrayChartsMisclassificationGenotypesReviewEffects of biasBiasPrediction modelPRS
2022
The construction of cross-population polygenic risk scores using transfer learning
Zhao Z, Fritsche L, Smith J, Mukherjee B, Lee S. The construction of cross-population polygenic risk scores using transfer learning. American Journal Of Human Genetics 2022, 109: 1998-2008. PMID: 36240765, PMCID: PMC9674947, DOI: 10.1016/j.ajhg.2022.09.010.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic risk scoresAncestry groupsTransferability of PRSPRS-CSPolygenic risk score methodsEuropean ancestry cohortsIndividuals of African ancestryIndividuals of South Asian ancestryNon-European ancestry groupsNon-European ancestrySouth Asian ancestryAssociation studiesDichotomous traitsSouth Asian sampleEuropean ancestryGenetic researchPRS modelAncestryAsian ancestryAfrican ancestryAfrican samplesUK BiobankRisk scoreAsian samples
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