2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-Wide Meta-AnalysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2023
LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.
Katsumata Y, Fardo D, Shade L, Bowen J, Crane P, Jarvik G, Keene C, Larson E, McCormick W, McCurry S, Mukherjee S, Kowall N, McKee A, Honig R, Lawrence S, Vonsattel J, Williamson J, Small S, Burke J, Hulette C, Welsh-Bohmer K, Gearing M, Lah J, Levey A, Wingo T, Apostolova L, Farlow M, Ghetti B, Saykin A, Spina S, Albert M, Lyketsos C, Troncoso J, Frosch M, Green R, Growdon J, Hyman B, Tanzi R, Potter H, Dickson D, Ertekin-Taner N, Graff-Radford N, Parisi J, Petersen R, Duara R, Buxbaum J, Goate A, Sano M, Masurkar A, Wisniewski T, Bigio E, Mesulam M, Weintraub S, Vassar R, Kaye J, Quinn J, Woltjer R, Barnes L, Bennett D, Schneider J, Yu L, Henderson V, Fallon K, Harrell L, Marson D, Roberson E, DeCarli C, Jin L, Olichney J, Kim R, LaFerla F, Monuki E, Head E, Sultzer D, Geschwind D, Vinters H, Chesselet M, Galasko D, Brewer J, Boxer A, Karydas A, Kramer J, Miller B, Rosen H, Seeley W, Burns J, Swerdlow R, Abner E, Fardo D, Van Eldik L, Albin R, Lieberman A, Paulson H, Arnold S, Trojanowski J, Van Deerlin V, Hamilton R, Kamboh M, Lopez O, Becker J, Cao C, Raj A, Smith A, Chui H, Miller C, Ringman J, Schneider L, Bird T, Sonnen J, Yu C, Grabowski T, Peskind E, Raskind M, Li G, Tsuang D, Asthana S, Atwood C, Carlsson C, Sager M, Chin N, Craft S, Cairns N, Morris J, Cruchaga C, Strittmatter S, Reiman E, Beach T, Huentelman M, Hardy J, Myers A, Kauwe J, Hakonarson H, Blacker D, Montine T, Baldwin C, Farrer L, Jun G, Lunetta K, Bush W, Haines J, Lerner A, Zhou X, Barral S, Reitz C, Vardarajan B, Mayeux R, Beecham G, Carney R, Cuccaro M, Gilbert J, Hamilton-Nelson K, Kunkle B, Martin E, Pericak-Vance M, Vance J, Cantwell L, Kuzma A, Malamon J, Naj A, Qu L, Schellenberg G, Valladares O, Wang L, Zhao Y, Leverenz J, De Jager P, Evans D, Katz M, Lipton R, Boeve B, Allen M, Carrasquillo M, Younkin S, Kukull W, Faber K, Foroud T, Pavlik V, Massman P, Darby E, Rodriguear M, Khaleeq A, Royall D, Stevens A, Ory M, DeToledo J, Wilms H, Johnson K, Perez V, Hernandez M, Wilhelmsen K, Tilson J, Chasse S, Barber R, Fairchild T, O’Bryant S, Knebl J, Hall J, Johnson L, Mains D, Alvarez L, Gamboa A, Paydarfar D, Bertelson J, Woon M, Ayres G, Aguirre A, Palmer R, Polk M, Adams P, Huebinger R, Reisch J, Rosenberg R, Cullum M, Williams B, Quiceno M, Hynan L, Smith J, Davis B, Nguyen T, Rogaeva E, George-Hyslop P, Nelson P. LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry. Journal Of Neuropathology & Experimental Neurology 2023, 82: 760-768. PMID: 37528055, PMCID: PMC10440720, DOI: 10.1093/jnen/nlad059.Peer-Reviewed Original ResearchConceptsSingle nucleotide variantsLimbic-predominant age-related TDP-43 encephalopathyAfrican ancestryRisk allelesIndividuals of African ancestryRisk-associated allelesTDP-43 proteinopathyGenetic risk factorsNucleotide variantsAllele frequenciesGenetic determinantsGenomics ConsortiumPersons of African ancestryTDP-43AllelesAncestryNational Alzheimer's Coordinating CenterDisease pathologyGenetic factorsNeuropathological featuresGRNAfrican American subjectsHippocampal sclerosisABCC9HS pathology
2022
The construction of cross-population polygenic risk scores using transfer learning
Zhao Z, Fritsche L, Smith J, Mukherjee B, Lee S. The construction of cross-population polygenic risk scores using transfer learning. American Journal Of Human Genetics 2022, 109: 1998-2008. PMID: 36240765, PMCID: PMC9674947, DOI: 10.1016/j.ajhg.2022.09.010.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic risk scoresAncestry groupsTransferability of PRSPRS-CSPolygenic risk score methodsEuropean ancestry cohortsIndividuals of African ancestryIndividuals of South Asian ancestryNon-European ancestry groupsNon-European ancestrySouth Asian ancestryAssociation studiesDichotomous traitsSouth Asian sampleEuropean ancestryGenetic researchPRS modelAncestryAsian ancestryAfrican ancestryAfrican samplesUK BiobankRisk scoreAsian samples
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