2023
Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration
Sekine Y, Wang X, Kikkawa K, Honda S, Strittmatter S. Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration. Journal Of Biological Chemistry 2023, 299: 105232. PMID: 37690690, PMCID: PMC10622843, DOI: 10.1016/j.jbc.2023.105232.Peer-Reviewed Original ResearchConceptsAxon regenerationCentral nervous system injuryPersistent neurological deficitsCerebral cortical neuronsNervous system injuryNeurological deficitsSystem injuryCNS injuryCortical neuronsAmino-terminal fragmentInjuryExtracellular actionPhysiological productionNogoInhibitory proteinMiceNeuronsInhibitory domainOverexpression increasesVaried resultsProteolytic fragmentsAxotomyExpressionNogoAGene targeting
2018
Diltiazem Promotes Regenerative Axon Growth
Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Diltiazem Promotes Regenerative Axon Growth. Molecular Neurobiology 2018, 56: 3948-3957. PMID: 30232777, PMCID: PMC6424671, DOI: 10.1007/s12035-018-1349-5.Peer-Reviewed Original ResearchConceptsL-type calcium channel blockerDorsal root gangliaCentral nervous systemChondroitin sulfate proteoglycanAxon regenerationMouse dorsal root gangliaAdult central nervous systemHuman sensory neuronsCalcium channel blockersSpinal cord injuryRat cortical culturesCord injuryAxonal regrowthRoot gangliaCortical culturesChannel blockersRegenerative propensityRegenerative axon growthSensory neuronsNervous systemPharmacological enhancersAxon growthPermanent lossSulfate proteoglycanAxotomy
2015
Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling. Neuron 2015, 85: 1244-1256. PMID: 25754821, PMCID: PMC4391013, DOI: 10.1016/j.neuron.2015.02.017.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsDownregulation of PTENGanglion cellsInsulin-like growth factor-1Mouse retinal ganglion cellsAdministration of osteopontinAbility of RGCsSubtype-specific differencesGrowth factor-1Effect of osteopontinAxonal regenerationIGF-1High mTORSurvival rateΑRGCsMTOR pathwayPromising agentAxotomyMTOR signalingDistinct subsetsFactor 1Existence of subpopulationsInjuryOsteopontinDownregulation
2011
In vivo Laser Axotomy in C. elegans
Byrne AB, Edwards TJ, Hammarlund M. In vivo Laser Axotomy in C. elegans. Journal Of Visualized Experiments 2011, 2707. PMID: 21633331, PMCID: PMC3168200, DOI: 10.3791/2707.Peer-Reviewed Original Research
2008
Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour
Holmes FE, Arnott N, Vanderplank P, Kerr NC, Longbrake EE, Popovich PG, Imai T, Combadière C, Murphy PM, Wynick D. Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour. Journal Of Neurochemistry 2008, 106: 640-649. PMID: 18410510, PMCID: PMC2726982, DOI: 10.1111/j.1471-4159.2008.05419.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnimalsBehavior, AnimalChemokine CX3CL1CX3C Chemokine Receptor 1Disease Models, AnimalDose-Response Relationship, DrugGanglia, SpinalGene Expression RegulationMacrophagesMaleMiceMice, Inbred BALB CMice, KnockoutPain MeasurementPain ThresholdReaction TimeReceptors, ChemokineRNA, MessengerSciaticaSpinal CordTime FactorsConceptsDorsal root gangliaNeuropathic pain-related behaviorLumbar dorsal root gangliaBALB/c controlsDevelopment of allodyniaIntra-neural injectionSciatic nerve proximalNeuropathic pain statesNerve injury modelSciatic nerve axotomyPain-related behaviorsExpression of CX3CR1Site of injuryNumber of cytokinesNeuropathic painNerve axotomyPain statesNerve proximalRoot gangliaSciatic nerveInjury modelCX3CR1 mRNAFractalkine mRNAKnockout miceAxotomy
2002
Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells
Black J, Dusart I, Sotelo C, Waxman S. Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells. Brain Research 2002, 101: 126-131. PMID: 12007840, DOI: 10.1016/s0169-328x(02)00200-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCerebellumDisease Models, AnimalFemaleGanglia, SpinalGene Expression RegulationImmunohistochemistryMultiple SclerosisNAV1.8 Voltage-Gated Sodium ChannelNeurons, AfferentNeuropeptidesPurkinje CellsRatsRats, WistarRNA, MessengerSodium ChannelsUp-RegulationZebrafish ProteinsConceptsMultiple sclerosisPurkinje cellsSensory neuron-specific sodium channelsDorsal root ganglion neuronsAberrant expressionSodium channelsHuman multiple sclerosisPrimary sensory neuronsSodium channel Nav1.8Specific sodium channelsCerebellar Purkinje cellsGanglion neuronsSensory neuronsAxotomySurgical modelSodium channel transcriptsExperimental modelCerebellar functionChannel transcriptsNeuronsSitu hybridizationCellsExpressionNav1.8Sclerosis
1999
Reduction in Potassium Currents in Identified Cutaneous Afferent Dorsal Root Ganglion Neurons After Axotomy
Everill B, Kocsis J. Reduction in Potassium Currents in Identified Cutaneous Afferent Dorsal Root Ganglion Neurons After Axotomy. Journal Of Neurophysiology 1999, 82: 700-708. PMID: 10444667, DOI: 10.1152/jn.1999.82.2.700.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsCutaneous afferent neuronsAfferent neuronsGanglion neuronsPotassium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsPrimary afferent neuronsEffects of axotomyPatch-clamp recordingsControl cellsAppropriate ion replacementAcute ligationNerve ligationDRG neuronsExcitability changesChannel blockersNeuronal excitabilityPharmacological componentsAxotomyNeuronsLigationBasis of sensitivityCellsBlockersChanges in expression of voltage‐gated potassium channels in dorsal root ganglion neurons following axotomy
Ishikawa K, Tanaka M, Black J, Waxman S. Changes in expression of voltage‐gated potassium channels in dorsal root ganglion neurons following axotomy. Muscle & Nerve 1999, 22: 502-507. PMID: 10204786, DOI: 10.1002/(sici)1097-4598(199904)22:4<502::aid-mus12>3.0.co;2-k.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsDRG neuronsVoltage-gated potassium channelsAxonal injuryGanglion neuronsPotassium channelsChannel expressionNormal DRG neuronsChronic pain syndromeSodium channel expressionSpectrum of subtypesVoltage-gated sodium channelsSpecific potassium channelsPain syndromeDRG cellsAdult ratsNervous systemAxotomyKv expressionNeuronsImmunocytochemical methodsMolecular correlatesElectrical excitabilitySodium channelsImmunoreactivity
1997
Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons
Zhang J, Donnelly D, Song X, Lamotte R. Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons. Journal Of Neurophysiology 1997, 78: 2790-2794. PMID: 9356426, DOI: 10.1152/jn.1997.78.5.2790.Peer-Reviewed Original ResearchConceptsDorsal root gangliaUnmyelinated axonsRoot gangliaSodium currentTTX-sensitive sodium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion cellsTTX-resistant currentC cellsEffects of axotomyAction potential thresholdPatch-clamp recordingsAction potential durationNeuropathic painVoltage-clamp conditionsPeak sodium currentDRG cellsGanglion cellsSoma sizeFast BlueNerve fibersConduction velocityAxotomyPotential duration
1995
Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy
Rizzo M, Kocsis J, Waxman S. Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiology Of Disease 1995, 2: 87-96. PMID: 8980012, DOI: 10.1006/nbdi.1995.0009.Peer-Reviewed Original Research
1982
Retrograde axon reaction following section of asynaptic nerve fibers
Waxman S, Anderson M. Retrograde axon reaction following section of asynaptic nerve fibers. Cell And Tissue Research 1982, 223: 487-492. PMID: 7093992, DOI: 10.1007/bf00218470.Peer-Reviewed Original Research
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