2012
Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation
Rismani-Yazdi H, Haznedaroglu BZ, Hsin C, Peccia J. Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation. Biotechnology For Biofuels And Bioproducts 2012, 5: 74. PMID: 23006831, PMCID: PMC3549901, DOI: 10.1186/1754-6834-5-74.Peer-Reviewed Original ResearchOleaginous microalga Neochloris oleoabundansTAG productionDe novo transcriptome assemblyMicroalga Neochloris oleoabundansBiofuel precursorsOleaginous microalgaeNovo transcriptome assemblyFatty acid synthesis pathwayMajor functional categoriesInorganic nitrogen assimilationGenetic engineering targetsHigh-quality readsRegulation of genesFatty acid biosynthesisCellular contentQuantitative gene expression analysisNitrogen-limiting conditionsΒ-oxidation pathwayGene expression analysisPyruvate dehydrogenase complexMapping of readsTAG biosynthesisNeochloris oleoabundansTranscriptome assemblyNitrogen assimilation
2009
AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells
Glushakova L, Lisankie M, Eruslanov E, Ojano-Dirain C, Zolotukhin I, Liu C, Srivastava A, Stacpoole P. AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. Molecular Genetics And Metabolism 2009, 98: 289-299. PMID: 19586787, PMCID: PMC2779054, DOI: 10.1016/j.ymgme.2009.05.010.Peer-Reviewed Original ResearchConceptsPyruvate dehydrogenase complexSubunit geneReporter geneWarburg effectCell deathCancer cellsGreen fluorescent reporter geneLiver cancer cellsAlpha-subunit geneFluorescent reporter geneHuman hepatoblastomaE1alpha subunit geneHuH-6 cellsApoptotic cell deathProtein expressionMitochondrial oxidative metabolismHuman alpha-fetoprotein promoterMitochondrial respiratory chain activityBeta-actin promoterRespiratory chain activityChicken beta-actin promoterReactive oxygen speciesExpression systemDehydrogenase complexMetabolic remodeling
1988
Mitochondrial enzymes in hereditary ataxias
Sheu K, Blass J, Cedarbaum J, Kim Y, Harding B, DeCicco J. Mitochondrial enzymes in hereditary ataxias. Metabolic Brain Disease 1988, 3: 151-160. PMID: 3185426, DOI: 10.1007/bf01001015.Peer-Reviewed Original ResearchConceptsHereditary ataxiasUnselected seriesCross-reacting materialSecondary decreasePatientsMitochondrial abnormalitiesAtaxiaPyruvate dehydrogenase complexMitochondrial damageMitochondrial enzymesPlateletsNormal fibroblastsGlutamate dehydrogenaseHuman brainAtaxyBrainImmunoblotFibroblastsPathophysiologyActivityAbnormalities
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