2022
Graft flow evaluation with intraoperative transit-time flow measurement in off-pump versus on-pump coronary artery bypass grafting
Leviner D, Rosati C, von Mücke Similon M, Amabile A, Thuijs D, Di Giammarco G, Wendt D, Trachiotis G, Kieser T, Kappetein A, Head S, Taggart D, Puskas J. Graft flow evaluation with intraoperative transit-time flow measurement in off-pump versus on-pump coronary artery bypass grafting. JTCVS Techniques 2022, 15: 95-106. PMID: 36276694, PMCID: PMC9579515, DOI: 10.1016/j.xjtc.2022.05.002.Peer-Reviewed Original ResearchMean graft flowMean arterial pressureONCAB groupPulsatility indexDiastolic fractionOPCAB groupIntraoperative transit time flow measurementPump coronary artery bypass proceduresPump coronary artery bypassPropensity score-matched comparisonCoronary artery bypass proceduresCoronary artery bypassPrimary end pointTransit-time flow measurementArtery bypass proceduresArtery bypassOPCAB proceduresOPCAB surgeryVenous graftsArterial pressureBypass proceduresGraft flowSurgery StudyArterial graftsSingle graft
2018
Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets
Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J. Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38: 1. PMID: 30571167, DOI: 10.1161/atvbaha.118.311822.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAnimalsBlood PlateletsCarrier ProteinsCell HypoxiaDisease Models, AnimalFemaleHumansMaleMechanistic Target of Rapamycin Complex 2Mice, Inbred C57BLMice, KnockoutMiddle AgedMyocardial InfarctionPhosphorylationPlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionSirtuin 3Superoxide DismutaseThrombosisConceptsOxygen speciesTarget AktSIN1Reactive oxygen speciesHypoxia responseNovel roleMyocardial infarctionIntegrin αIIbβ3Downstream signalsValuable therapeutic targetCell proliferationAktDeficiency micePhosphorylationST-segment elevation myocardial infarctionPlatelet activationLeft anterior descending (LAD) obstructionPump coronary artery bypassSignalingSpeciesTherapeutic targetΑIIbβ3Coronary artery bypass
2017
Pattern and predictors of dual antiplatelet use after coronary artery bypass graft surgery
Mori M, Shioda K, Yun JJ, Mangi AA, Darr U, Geirsson A. Pattern and predictors of dual antiplatelet use after coronary artery bypass graft surgery. Journal Of Thoracic And Cardiovascular Surgery 2017, 155: 632-638. PMID: 29056263, DOI: 10.1016/j.jtcvs.2017.09.092.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedClinical Decision-MakingConnecticutCoronary Artery BypassDrug Administration ScheduleDrug Therapy, CombinationFemaleHemorrhageHumansMaleMiddle AgedPatient DischargePlatelet Aggregation InhibitorsPractice Patterns, Physicians'RecurrenceRetrospective StudiesRisk AssessmentRisk FactorsSurgeonsTime FactorsTreatment OutcomeConceptsDual antiplatelet therapy useCoronary artery bypassAntiplatelet therapy useDual antiplatelet therapyAcute coronary syndromePump coronary artery bypassArtery bypassTherapy useAntiplatelet therapyCoronary syndromeSurgeon preferenceMixed-effects multivariate logistic regressionCoronary artery bypass graft surgeryMixed-effects multivariate modelsArtery bypass graft surgeryCoronary Artery Bypass GraftingSingle-center retrospective reviewYale-New Haven HospitalDual antiplatelet useArtery Bypass GraftingBypass graft surgeryCurrent practice patternsMultivariate logistic regressionAntiplatelet useBypass GraftingMinimally invasive coronary artery bypass grafting: a systematic review
Kikuchi K, Mori M. Minimally invasive coronary artery bypass grafting: a systematic review. Asian Cardiovascular And Thoracic Annals 2017, 25: 364-370. PMID: 28673140, DOI: 10.1177/0218492317692465.Peer-Reviewed Original ResearchConceptsBilateral internal thoracic arteryInvasive coronary artery bypassCoronary artery bypassInternal thoracic arteryArtery bypassThoracic arteryInvasive cardiac surgeryCardiac surgeryInvasive direct coronary artery bypassOff-pump coronary artery bypassDirect coronary artery bypassPump coronary artery bypassHybrid coronary revascularizationArmamentarium of surgeonsCoronary revascularizationSmall thoracotomySurgical morbidityEarly outcomesPatient populationSurgical techniqueCurrent evidenceBypassSystematic reviewArteryRevascularization
2008
Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass
Grant M, Kon Z, Joshi A, Christenson E, Kallam S, Burris N, Gu J, Poston R. Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass. The Annals Of Thoracic Surgery 2008, 86: 815-822. PMID: 18721566, PMCID: PMC2649734, DOI: 10.1016/j.athoracsur.2008.04.047.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCoronary artery bypassThrombotic eventsAprotinin levelsAprotinin useArtery bypassDay 3Off-pump coronary artery bypassMore acute kidney injuryPostoperative acute kidney injurySubsequent acute kidney injuryPump coronary artery bypassAcute graft failureAdverse thrombotic eventsWeight-based protocolPercentage of patientsGlomerular filtration rateFavorable safety profileMultiple randomized trialsPostoperative hypercoagulable stateEGFR declineCerebrovascular eventsKidney injuryLower eGFRPlacebo groupWarm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition
Kon Z, Brown E, Grant M, Ozeki T, Burris N, Collins M, Kwon M, Poston R. Warm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition. European Journal Of Cardio-Thoracic Surgery 2008, 33: 215-221. PMID: 18068996, PMCID: PMC2605708, DOI: 10.1016/j.ejcts.2007.11.008.Peer-Reviewed Original ResearchConceptsPump coronary artery bypassCoronary artery bypassTranscardiac gradientCoronary occlusionArtery bypassMyocardial ischemiaTNF-alphaCoronary sinus bloodEarly graft failureRegional myocardial ischemiaProthrombotic stateGraft failureProtamine administrationSinus bloodConsecutive patientsIschemic injuryMyocardial injuryIL-8Warm ischemiaPathophysiologic consequencesSeries of biomarkersCoagulation systemOPCABIschemiaInflammation
2007
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass
Kon Z, Brown E, Tran R, Joshi A, Reicher B, Grant M, Kallam S, Burris N, Connerney I, Zimrin D, Poston R. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. Journal Of Thoracic And Cardiovascular Surgery 2007, 135: 367-375. PMID: 18242270, PMCID: PMC2962576, DOI: 10.1016/j.jtcvs.2007.09.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceCase-Control StudiesCohort StudiesCoronary AngiographyCoronary Artery Bypass, Off-PumpCoronary StenosisFemaleFollow-Up StudiesHumansInternal Mammary-Coronary Artery AnastomosisLength of StayLogistic ModelsMaleMiddle AgedPain, PostoperativePilot ProjectsPostoperative ComplicationsProbabilityRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeVascular PatencyConceptsPump coronary artery bypassCoronary artery bypassTarget vessel patencyActivation of coagulationArtery bypassMyocardial injuryHybrid procedureOff-pump coronary artery bypassMultivessel coronary artery diseaseSimultaneous hybrid coronary revascularizationLeft internal thoracic arteryHybrid coronary revascularizationInternal thoracic arteryCoronary artery diseaseIntensive care unitBetter perioperative outcomesEnzyme-linked immunosorbentPromising preliminary findingsOverall total costTranscardiac gradientCoronary revascularizationPerioperative morbidityPerioperative outcomesPostoperative morbidityArtery disease
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