2024
Psilocybin-assisted psychotherapy improves psychiatric symptoms across multiple dimensions in patients with cancer
Petridis P, Grinband J, Agin-Liebes G, Kinslow C, Zeifman R, Bogenschutz M, Griffiths R, Ross S. Psilocybin-assisted psychotherapy improves psychiatric symptoms across multiple dimensions in patients with cancer. Nature Mental Health 2024, 2: 1408-1414. DOI: 10.1038/s44220-024-00331-0.Peer-Reviewed Original ResearchPsilocybin-assisted psychotherapyInterpersonal sensitivityObsession-compulsionPsychiatric symptomsPsychiatric symptom dimensionsMental health treatmentPlacebo-controlled crossover trialSymptom dimensionsAnxiety disordersTreating moodHealth treatmentImprove anxietyCancer-related distressAnxietyDepressionPsychotherapyPhobiaPsychosisParanoiaSomatizationHostilityCrossover trialSymptomsMultiple dimensionsClinical improvement
2021
Acute and Sustained Reductions in Loss of Meaning and Suicidal Ideation Following Psilocybin-Assisted Psychotherapy for Psychiatric and Existential Distress in Life-Threatening Cancer
Ross S, Agin-Liebes G, Lo S, Zeifman R, Ghazal L, Benville J, Corso S, Real C, Guss J, Bossis A, Mennenga S. Acute and Sustained Reductions in Loss of Meaning and Suicidal Ideation Following Psilocybin-Assisted Psychotherapy for Psychiatric and Existential Distress in Life-Threatening Cancer. ACS Pharmacology & Translational Science 2021, 4: 553-562. PMID: 33860185, PMCID: PMC8033770, DOI: 10.1021/acsptsci.1c00020.Peer-Reviewed Original ResearchSuicidal ideationElevated levels of depressionPsilocybin-assisted psychotherapyLevels of depressionWithin-group reductionsAntisuicidal effectsPsilocybin treatmentAntidepressant medicationCancer diagnosisCompleted SuicideLoss of meaningBetween-group differencesApparent 2 weeksComposite scoreDemoralizationHeightened riskDepressionSuicideExploratory analysisMonths postdosingRandomized Controlled TrialsExistential distressIdeationHopelessnessHastened death
2020
Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer
Agin-Liebes G, Malone T, Yalch M, Mennenga S, Ponté K, Guss J, Bossis A, Grigsby J, Fischer S, Ross S. Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. Journal Of Psychopharmacology 2020, 34: 155-166. PMID: 31916890, DOI: 10.1177/0269881119897615.Peer-Reviewed Original ResearchConceptsPsilocybin-assisted psychotherapyLife-threatening cancerAnxiolytic responseExistential distressPsychiatric distressLong-term reliefQuality of lifeGroup effect sizesSubset of participantsSelf-reported symptomatologyParent trialPresent studySecond followPsilocybin administrationParent studyCrossover designPositive life changesTherapy experiencePatientsSpiritual wellDistressTherapyCancerEffect sizeLife changes
2018
Individual Experiences in Four Cancer Patients Following Psilocybin-Assisted Psychotherapy
Malone TC, Mennenga SE, Guss J, Podrebarac SK, Owens LT, Bossis AP, Belser AB, Agin-Liebes G, Bogenschutz MP, Ross S. Individual Experiences in Four Cancer Patients Following Psilocybin-Assisted Psychotherapy. Frontiers In Pharmacology 2018, 9: 256. PMID: 29666578, PMCID: PMC5891594, DOI: 10.3389/fphar.2018.00256.Peer-Reviewed Original ResearchCancer-related anxietyPsilocybin-assisted psychotherapyCancer patientsAnti-depressant effectsUnique clinical courseBetter medical outcomesQuality of lifeEffects of psilocybinClinical courseBody of evidenceHastened deathClinician notesMedical outcomesPatientsCancer diagnosisDepressionImproved qualityAcceptance of deathTrialsPsilocybinDeathAnxietyTreatmentPsychotherapyPast trauma
2017
Cancer at the Dinner Table: Experiences of Psilocybin-Assisted Psychotherapy for the Treatment of Cancer-Related Distress
Swift T, Belser A, Agin-Liebes G, Devenot N, Terrana S, Friedman H, Guss J, Bossis A, Ross S. Cancer at the Dinner Table: Experiences of Psilocybin-Assisted Psychotherapy for the Treatment of Cancer-Related Distress. Journal Of Humanistic Psychology 2017, 57: 488-519. DOI: 10.1177/0022167817715966.Peer-Reviewed Original ResearchPsilocybin-assisted psychotherapyClose clinical supervisionQuality of lifeLarge magnitude reductionAvailable emotional supportRecent randomizedTreatment of cancerSingle dosePsilocybin therapyDisease progressionCancer recurrenceCancer placesPatient experienceClinical treatmentCancerPsilocybin sessionCancer diagnosisElevated anxietyAdult participantsInterpretative phenomenological analysisDeathTranscribed interviewsDistressing effectsPsychological mechanismsSemistructured interviews
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