2024
Psilocybin-assisted psychotherapy improves psychiatric symptoms across multiple dimensions in patients with cancer
Petridis P, Grinband J, Agin-Liebes G, Kinslow C, Zeifman R, Bogenschutz M, Griffiths R, Ross S. Psilocybin-assisted psychotherapy improves psychiatric symptoms across multiple dimensions in patients with cancer. Nature Mental Health 2024, 2: 1408-1414. DOI: 10.1038/s44220-024-00331-0.Peer-Reviewed Original ResearchPsilocybin-assisted psychotherapyInterpersonal sensitivityObsession-compulsionPsychiatric symptomsPsychiatric symptom dimensionsMental health treatmentPlacebo-controlled crossover trialSymptom dimensionsAnxiety disordersTreating moodHealth treatmentImprove anxietyCancer-related distressAnxietyDepressionPsychotherapyPhobiaPsychosisParanoiaSomatizationHostilityCrossover trialSymptomsMultiple dimensionsClinical improvement
2017
Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial
Taylor JH, Landeros-Weisenberger A, Coughlin C, Mulqueen J, Johnson JA, Gabriel D, Reed MO, Jakubovski E, Bloch MH. Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial. Neuropsychopharmacology 2017, 43: 325-333. PMID: 28849779, PMCID: PMC5729569, DOI: 10.1038/npp.2017.194.Peer-Reviewed Original ResearchConceptsLiebowitz Social Anxiety ScaleSocial anxiety disorderAnxiety disordersSocial Anxiety ScaleSelf-reported anxietySocial phobia symptomsRatings of anxietyPotent N-methyl-d-aspartate receptor antagonistPhobia symptomsAnxiety symptomsAnxiety ScaleImpact of ketamineInitial evidenceAnxietyTreatment respondersVAS anxietyPlacebo-controlled crossover trialRatingsDisordersLinear mixed modelsPrior studiesConcept trialInadequate symptom reliefRandom orderMixed models
2003
Raloxifene and endothelial function in healthy postmenopausal women
Sarrel PM, Nawaz H, Chan W, Fuchs M, Katz DL. Raloxifene and endothelial function in healthy postmenopausal women. American Journal Of Obstetrics And Gynecology 2003, 188: 304-309. PMID: 12592230, DOI: 10.1067/mob.2003.28.Peer-Reviewed Original ResearchConceptsPostmenopausal womenEndothelial functionPlacebo-controlled crossover trialEndothelial-mediated dilationLaser Doppler measuresEffects of raloxifeneFlow-mediated dilationHealthy postmenopausal womenBrachial artery diameter changesArtery diameter changesWarrants further studyBrachial arteryCardioprotective effectsCrossover trialDoppler measuresCurve ratioHyperemic stimulusRaloxifenePlaceboStimulus intensityDigital vesselsPotential mechanismsRatio of areaWomenFurther studies
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rateSustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study
van Dyck CH, McMahon TJ, Rosen MI, O'Malley SS, O'Connor PG, Lin CH, Pearsall HR, Woods SW, Kosten TR. Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study. Journal Of Neuropsychiatry 1997, 9: 29-36. PMID: 9017526, DOI: 10.1176/jnp.9.1.29.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCentral Nervous System StimulantsCognition DisordersDelayed-Action PreparationsDouble-Blind MethodFemaleHIV InfectionsHIV-1HumansLearningMaleMemoryMethylphenidateMiddle AgedNeuropsychological TestsOpioid-Related DisordersPilot ProjectsPsychomotor PerformanceSubstance-Related DisordersConceptsSustained-release methylphenidateCognitive impairmentDouble-blind placebo-controlled crossover trialPlacebo-controlled crossover trialComposite neuropsychological measuresImpaired neuropsychological test performanceClinical improvementPlacebo treatmentCrossover trialMethadone patientsNeuropsychological test performancePlacebo performancePsychostimulant drugsDrug abusersPatientsStudy designPilot studySubstance abusersImpairmentNeuropsychological measuresMethylphenidateMore improvementAbusersTreatmentTest performance
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