Factor VIII prophylaxis effects outweigh other hemostasis contributors in predicting severe haemophilia A joint outcomes
Warren B, Jacobson L, Kempton C, Buchanan G, Recht M, Brown D, Leissinger C, Shapiro A, Abshire T, Manco‐Johnson M, Investigators F. Factor VIII prophylaxis effects outweigh other hemostasis contributors in predicting severe haemophilia A joint outcomes. Haemophilia 2019, 25: 867-875. PMID: 31115111, PMCID: PMC7273872, DOI: 10.1111/hae.13778.Peer-Reviewed Original ResearchConceptsFactor VIIITreatment armsGlobal assaysGlobal assays of coagulationFactor VIII half-lifeUnivariate logistic regression analysisFVIII half-lifeAged 6Treatment adherenceAssays of coagulationPresence of subchondral cystsProphylactic factor VIIILogistic regression analysisFVIII infusionHalf-lifeAssociation of variablesJoint-space narrowingHemophilia AUntreated childrenOutcome parametersSevere haemophiliaProphylaxis effectAnticoagulant proteinsLogistic regressionSubchondral cysts
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