2021
The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial
Li M, Liu Y, Qiu Y, Zhang J, Zhang Y, Zhao Y, Jia Q, Li J. The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial. Psychiatry Research 2021, 300: 113899. PMID: 33812218, DOI: 10.1016/j.psychres.2021.113899.Peer-Reviewed Original ResearchConceptsAdjunctive treatmentNon-psychiatric patientsDouble-blindSerum prolactin concentrationsPlacebo-controlled clinical trialSchizophreniaMetabolic disturbancesGlycolipid metabolic parametersBaseline body mass indexImprove metabolic disturbancesLow-density lipoprotein cholesterolProlactin concentrationsSixty-five patientsFasting serum insulinWeek 8Body mass indexEffects of berberineLipoprotein cholesterolMass indexPlaceboWeek 4Previous studiesClinical trialsMetabolic parametersTotal cholesterol
2002
Correlation of Antipsychotic and Prolactin Concentrations in Children and Adolescents Acutely Treated with Haloperidol, Clozapine, or Olanzapine
Alfaro C, Wudarsky M, Nicolson R, Gochman P, Sporn A, Lenane M, Rapoport J. Correlation of Antipsychotic and Prolactin Concentrations in Children and Adolescents Acutely Treated with Haloperidol, Clozapine, or Olanzapine. Journal Of Child And Adolescent Psychopharmacology 2002, 12: 83-91. PMID: 12188977, DOI: 10.1089/104454602760219126.Peer-Reviewed Original ResearchConceptsSerum prolactin concentrationsDouble-blind trialProlactin concentrationsAntipsychotic plasma concentrationsOlanzapine treatment groupOlanzapine plasma concentrationsTrial of haloperidolDiagnosis of schizophreniaNo gender differencesAntipsychotic dosePsychotic disordersOlanzapineHaloperidolClozapineSerum prolactinPlasma concentrationsGender differencesTreatment groupsProlactinAntipsychoticsDesmethylclozapineSchizophreniaPsychosisBlood samplesSerum
1999
Elevated Prolactin in Pediatric Patients on Typical and Atypical Antipsychotics
Wudarsky M, Nicolson R, Hamburger S, Spechler L, Gochman P, Bedwell J, Lenane M, Rapoport J. Elevated Prolactin in Pediatric Patients on Typical and Atypical Antipsychotics. Journal Of Child And Adolescent Psychopharmacology 1999, 9: 239-245. PMID: 10630453, DOI: 10.1089/cap.1999.9.239.Peer-Reviewed Original ResearchConceptsTrial of haloperidolAtypical antipsychoticsDouble-blind trialWeeks of treatmentSafety of atypical antipsychoticsExposure to olanzapineChildhood-onset schizophreniaEarly onset psychosisBaseline serum prolactinCardiac correlatesProlactin elevationPsychotic disordersClozapineOlanzapineHaloperidolPediatric patientsElevated prolactinSerum prolactinTreatment safetyAntipsychoticsProlactin concentrationsPsychosisProlactinWeek 6Washout period
1982
Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate.
Shaywitz S, Hunt R, Jatlow P, Cohen D, Young J, Pierce R, Anderson G, Shaywitz B. Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate. 1982, 69: 688-94. PMID: 7079034, DOI: 10.1542/peds.69.6.688.Peer-Reviewed Original ResearchConceptsAcute studyMPH concentrationsGrowth hormoneObserved maximal concentrationCentral dopaminergic mechanismsPeak plasma concentrationAdministration of medicationsPharmacokinetics of methylphenidatePlasma growth hormoneConcentrations of methylphenidatePlasma MPH concentrationsAttention deficit disorderClinical responseChronic treatmentDopaminergic mechanismsGroup of childrenDisorders of attentionAbbreviated Conners' Rating ScaleSchool-aged childrenOral administrationPlasma concentrationsClinical pharmacologyMPH administrationProlactin concentrationsPercentage of improvement
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