2015
Use of three-dimensional mapping in young patients decreases radiation exposure even without a goal of zero fluoroscopy
Beach C, Beerman L, Mazzocco S, Brooks MM, Arora G. Use of three-dimensional mapping in young patients decreases radiation exposure even without a goal of zero fluoroscopy. Cardiology In The Young 2015, 26: 1297-1302. PMID: 26507259, DOI: 10.1017/s1047951115002449.Peer-Reviewed Original ResearchConceptsFluoroscopy timeCatheterisation timeGroup 2Group 3Atrioventricular nodal re-entrant tachycardiaNodal re-entrant tachycardiaRadiation exposureAverage fluoroscopy timeRe-entrant tachycardiaUnadjusted linear regression modelsAcute successYounger patientsComplication rateCryoablation techniqueChronic successRadiofrequency ablationFluoroscopy useGroup 1PatientsCryoablationProgressive decreaseCardiac ablationLinear regression modelsThree-dimensional mappingAblation timeDynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
Sondo P, Derra K, Tarnagda Z, Nakanabo S, Zampa O, Kazienga A, Valea I, Sorgho H, Ouedraogo J, Guiguemde T, Tinto H. Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso. Pan African Medical Journal 2015, 21: 101. PMID: 26516402, PMCID: PMC4606025, DOI: 10.11604/pamj.2015.21.101.6437.Peer-Reviewed Original Research
2011
Adult glioblastoma multiforme survival in the temozolomide era: A population‐based analysis of Surveillance, Epidemiology, and End Results registries
Darefsky AS, King JT, Dubrow R. Adult glioblastoma multiforme survival in the temozolomide era: A population‐based analysis of Surveillance, Epidemiology, and End Results registries. Cancer 2011, 118: 2163-2172. PMID: 21882183, PMCID: PMC3235223, DOI: 10.1002/cncr.26494.Peer-Reviewed Original ResearchConceptsHazard ratioTemozolomide eraMultivariate-adjusted hazard ratiosEnd Results Program databaseKaplan-Meier methodPopulation-based surveillanceTwo-year survivalAge-stratified analysisConfidence intervalsPopulation-based analysisAge 20 yearsProportional hazards modelProgressive decreaseTemozolomide useOlder patientsSurgical resectionSurvival improvementTreatment advancesProgram databaseGBM patientsHazards modelGBM treatmentAge 20Age groupsGlioblastoma multiforme survival
2000
Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model
Daher E, Dione D, Heller E, Holahan J, DeMan P, Shen M, Hu J, Sinusas A. Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model. Journal Of Nuclear Cardiology 2000, 7: 112-122. PMID: 10796000, DOI: 10.1016/s1071-3581(00)90031-x.Peer-Reviewed Original ResearchConceptsCoronary flow reserveRemote nonischemic regionsProximal occlusionNonischemic regionsThickening fractionCanine modelDistal occlusionCoronary flowIschemic areaFlow reserveMechanical etiologyLeft ventricleLeft circumflex artery regionAnterior descending (LAD) coronary artery occlusionProgressive decreaseAnesthetized open-chest canine modelCoronary artery occlusionExtent of ischemiaGlobal hemodynamic parametersProximal coronary occlusionRegional ischemic dysfunctionAcute canine modelImportant clinical implicationsOpen-chest canine modelMicrosphere blood flow
1999
Zinc Inhibits Protein Synthesis in Neurons POTENTIAL ROLE OF PHOSPHORYLATION OF TRANSLATION INITIATION FACTOR-2α*
Alirezaei M, Nairn A, Glowinski J, Prémont J, Marin P. Zinc Inhibits Protein Synthesis in Neurons POTENTIAL ROLE OF PHOSPHORYLATION OF TRANSLATION INITIATION FACTOR-2α*. Journal Of Biological Chemistry 1999, 274: 32433-32438. PMID: 10542287, DOI: 10.1074/jbc.274.45.32433.Peer-Reviewed Original ResearchConceptsCultured cortical neuronsEukaryotic elongation factor 2Central nervous systemFactor 2Translation initiation factor 2αProtein synthesisCerebral cortexCortical neuronsNervous systemProfound inhibitionSustained increaseBasal levelsTransient increaseBasal ratePotential roleProgressive decreaseInhibits protein synthesisNeuronsAmount of polyribosomesElongation factor 2EIF-2alpha phosphorylationAlpha subunitInhibitionPhosphorylationEukaryotic initiation factor 2
1994
Temporal Association Between Implementation of Universal Precautions and a Sustained, Progressive Decrease in Percutaneous Exposures to Blood
Beekmann S, Vlahov D, Koziol D, McShalley E, Schmitt J, Henderson D. Temporal Association Between Implementation of Universal Precautions and a Sustained, Progressive Decrease in Percutaneous Exposures to Blood. Clinical Infectious Diseases 1994, 18: 562-569. PMID: 8038311, DOI: 10.1093/clinids/18.4.562.Peer-Reviewed Original ResearchConceptsUniversal precautionsParenteral injuriesHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionTemporal associationParenteral exposurePostexposure chemoprophylaxisPercutaneous injuriesPercutaneous exposureOccupational infectionClinical centersOccupational exposureVirus infectionInjurySignificant decreaseNational InstituteProgressive decreaseInfectionBloodExposureRapid reportingPrecautionsAssociationChemoprophylaxisZidovudineRole of elongation factor 2 in regulating peptide-chain elongation in the heart
Vary T, Nairn A, Lynch C. Role of elongation factor 2 in regulating peptide-chain elongation in the heart. American Journal Of Physiology 1994, 266: e628-e634. PMID: 7513958, DOI: 10.1152/ajpendo.1994.266.4.e628.Peer-Reviewed Original ResearchConceptsDiabetic ratsEF-2 contentFactor 2Protein synthesisInsulin therapyIncrease of RNADecreased translational efficiencyElongation factor 2RatsDiabetesCardiac muscleImpaired rateDecreased rateProgressive decreaseHeartInhibitionMolecular mechanismsRNA contentPeptide chain elongationH durationTherapyInsulinDecrease
1993
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.Peer-Reviewed Original ResearchConceptsInward currentsDorsal root ganglion neuronsDorsal root ganglion cellsCapsaicin-evoked currentsWhole-cell voltage-clamp conditionsImportant modulatory roleVoltage-clamp conditionsDRG cellsGanglion neuronsGanglion cellsSensory neuronsModulatory roleCapsaicinProgressive decreaseNeuronsCellsExtracellular medium
1989
Effect of hemoglobin concentration on critical cardiac output and oxygen transport
Heusser F, Fahey JT, Lister G. Effect of hemoglobin concentration on critical cardiac output and oxygen transport. American Journal Of Physiology 1989, 256: h527-h532. PMID: 2916686, DOI: 10.1152/ajpheart.1989.256.2.h527.Peer-Reviewed Original ResearchConceptsSystemic O2 transportPeripheral O2 extractionCardiac outputO2 extractionFractional O2 extractionHemoglobin concentrationArterial blood lactate concentrationBase-line cardiac outputBalloon-tipped catheterPacked red cellsBlood lactate concentrationO2 transportPhysiological anaemiaExchange transfusionAcute reductionRight atriumVenous PO2Relative anemiaLactate concentrationOld lambsRed cellsAnemiaProgressive decreaseBase lineO2 consumption
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