2025
Embryonic mast cells arise from the Cpa3-expressing precursors but not granulocyte-monocyte progenitors
Ma W, Chen H, Gao F, Zhao H, Wu N, Zhang S, Zhu Y, Xu Z, Lan Y, Liu B, Ye Y, Liu Z, Ginhoux F, Su B. Embryonic mast cells arise from the Cpa3-expressing precursors but not granulocyte-monocyte progenitors. Science China Life Sciences 2025, 68: 2363-2378. PMID: 40419842, DOI: 10.1007/s11427-024-2891-1.Peer-Reviewed Original ResearchConceptsGranulocyte-monocyte progenitorsMast cellsFetal liverMC precursorsEarly yolk sacIn vivo transplantation assaysSkin mast cellsDermal mast cellsIn vitro differentiationYolk sacImmune cellsTransplantation assaysSingle-cell RNA sequencingEmbryonic dayImmunological diseasesEmbryonic hematopoiesisPeripheral tissuesHost defenseEmbryonic originConnective tissueFate mappingFunctional studiesRNA sequencingDevelopmental programLiverEngineering Mice to Study Human Immunity
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025, 43: 451-487. PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Original ResearchHumanized miceHuman hematopoiesisImmune responseImmune systemHumanized mouse modelHuman hematopoietic stemImmunocompromised murine hostsResident immune cellsHuman immune responseStudy human immunityHuman immune systemIntegration of multi-omicsHematopoietic stemImmune cell growthImmune cellsEngineered MiceProgenitor cellsMouse modelImmunological diseasesMurine hostCancer treatmentPreclinical drugsHuman immunityMiceModel disease
2023
Guidelines for best practices in monitoring established coeliac disease in adult patients
Elli L, Leffler D, Cellier C, Lebwohl B, Ciacci C, Schumann M, Lundin K, Chetcuti Zammit S, Sidhu R, Roncoroni L, Bai J, Lee A, Dennis M, Robert M, Rostami K, Khater S, Comino I, Cebolla A, Branchi F, Verdu E, Stefanolo J, Wolf R, Bergman-Golden S, Trott N, Scudeller L, Zingone F, Scaramella L, Sanders D. Guidelines for best practices in monitoring established coeliac disease in adult patients. Nature Reviews Gastroenterology & Hepatology 2023, 21: 198-215. PMID: 38110546, DOI: 10.1038/s41575-023-00872-2.Peer-Reviewed Original ResearchConceptsCoeliac diseaseLevel of evidenceLife-long gluten-free dietGluten-free dietMucosal atrophyAdult patientsCirculating autoantibodiesFollow-upGenetic predispositionImmunological diseasesRecommendations AssessmentMonitoring PatientsClinical guidelinesEvidence levelPatientsConsumption of glutenDiagnosisDiseaseGuidelinesScientific societiesCEDAutoantibodiesGastroenterologistsAtrophy
2022
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism 2022, 34: 595-614.e14. PMID: 35276062, PMCID: PMC8986623, DOI: 10.1016/j.cmet.2022.02.009.Peer-Reviewed Original ResearchConceptsCAR T cellsT cell-based immunotherapyRight molecular targetCell-based immunotherapyCAR-T therapyChimeric antigen receptorMultiple cancer modelsCAR-T efficacyFunction CRISPR screensCD8 TPrimary CD8Immune functionImmunological diseasesImmune boosterCancer modelAntigen receptorDistinct gene expressionMolecular targetsCRISPR activation screensMetabolic programsImmunological analysisTherapyCancerEfficacyActivation screens
2019
Potential role of regulatory B cells in immunological diseases
Valizadeh A, Sanaei R, Rezaei N, Azizi G, Fekrvand S, Aghamohammadi A, Yazdani R. Potential role of regulatory B cells in immunological diseases. Immunology Letters 2019, 215: 48-59. PMID: 31442542, DOI: 10.1016/j.imlet.2019.08.004.Peer-Reviewed Original ResearchConceptsRegulatory B cellsB cellsImmune systemChronic infectious diseasePotential therapeutic strategyMechanism of actionCytokine productionImmunomodulatory effectsPrimary immunodeficiencyTherapeutic strategiesImmunological diseasesTherapeutic effortsInfectious diseasesExact phenotypeDiseaseFindings of humanPotential roleBregsDiverse diseasesCellsCellular interactionsOngoing investigationAutoimmunityAllergyMalignancy
2017
The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer
Uribe DJ, Mandell EK, Watson A, Martinez JD, Leighton JA, Ghosh S, Rothlin CV. The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PLOS ONE 2017, 12: e0179979. PMID: 28727830, PMCID: PMC5519024, DOI: 10.1371/journal.pone.0179979.Peer-Reviewed Original ResearchConceptsColorectal cancerTAM receptor tyrosine kinasesReceptor tyrosine kinasesLate-stage colorectal cancerColitis-associated cancerStage colorectal cancerAnti-inflammatory effectsReceptor tyrosine kinase AXLTyro3 receptor tyrosine kinasesSufficient therapeutic benefitTyrosine kinase AXLNumber of cancersTYRO3 expressionChronic inflammationAllergic responsesTherapeutic benefitTumor cell migrationImmunological diseasesExpression associatesIndiscriminate inhibitionGene signatureAxlAxl kinase activityInflammationCancer
2015
Genomics of Immune Diseases and New Therapies
Lenardo M, Lo B, Lucas CL. Genomics of Immune Diseases and New Therapies. Annual Review Of Immunology 2015, 34: 1-29. PMID: 26735698, PMCID: PMC5736009, DOI: 10.1146/annurev-immunol-041015-055620.Peer-Reviewed Original ResearchConceptsDNA sequencing technologiesMagnesium transportersSequencing technologiesNew genetic diseasesGenomicsGenetic lossGenetic diseasesMolecular definitionGenetic pathogenesisPatient phenotypesBiochemical investigationsImmune regulationImmune diseasesPrecision medicine treatmentImmunological diseasesNew therapiesGenetic counselingTransportersAdditional examplesPhenotypeRegulationGreat advancesImproved diagnosisIdentifying genetic determinants of autoimmunity and immune dysregulation
Lucas CL, Lenardo MJ. Identifying genetic determinants of autoimmunity and immune dysregulation. Current Opinion In Immunology 2015, 37: 28-33. PMID: 26433354, PMCID: PMC5583726, DOI: 10.1016/j.coi.2015.09.001.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCommon autoimmune diseaseHealth care costsRare immune diseasesMendelian disease mutationsExperiments of natureMendelian inheritance patternImmune dysregulationAutoimmune diseasesCell transplantationChronic diseasesDisease-causing genesImmune regulationImmune diseasesImmunological diseasesHuman locusTherapeutic targetCare costsGenetic insightsDiseaseDisease mutationsGenetic determinantsPolygenic diseaseDisease susceptibilityInteractive Big Data Resource to Elucidate Human Immune Pathways and Diseases
Gorenshteyn D, Zaslavsky E, Fribourg M, Park CY, Wong AK, Tadych A, Hartmann BM, Albrecht RA, García-Sastre A, Kleinstein SH, Troyanskaya OG, Sealfon SC. Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases. Immunity 2015, 43: 605-614. PMID: 26362267, PMCID: PMC4753773, DOI: 10.1016/j.immuni.2015.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBayes TheoremComputational BiologyGene Regulatory NetworksHost-Pathogen InteractionsHumansImmune SystemImmune System DiseasesInternetProtein Interaction MappingProtein Interaction MapsReproducibility of ResultsSignal TransductionSupport Vector MachineTranscriptomeVirus DiseasesConceptsPublic high-throughput dataGenome-scale experimentsDisease-associated genesHigh-throughput datasetsHigh-throughput dataData-driven hypothesesGenetic studiesImmune pathwaysGenesImmunological diseasesFunctional relationshipBiomedical research effortsImportant interactionsMolecular entitiesImmune systemHuman immune systemProteinExponential growthPathwayData resourcesBayesian integrationRelevant insightsGrowthCompendiumIdentification
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