2023
Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2021
Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme, following administration of single and multiple doses to healthy volunteers
Kielbasa W, Shcherbinin S, Goldsmith P, Phipps K, Biglan K, Mancini M, Russell D, Constantinescu C, Gunn R, Nuthall H, Mergott D, Lowe S, Collins E. Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme, following administration of single and multiple doses to healthy volunteers. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.057774.Peer-Reviewed Original ResearchHealthy volunteersEnzyme occupancyPET scansSingle doseMultiple-dose clinical studiesPost-dose intervalPositron emission tomography radioligandBaseline PET scanLonger clinical trialsTarget occupancyTau-related diseasesMultiple dosesMultiple dosingClinical trialsPlasma pharmacokineticsClinical studiesEfficacy trialsSD studiesDose selectionTomography radioligandEnzyme inhibitorsPotential treatmentAlzheimer's diseasePET studiesTarget engagement
2020
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task
Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.Peer-Reviewed Original ResearchConceptsVisual cortexVisual stimulationPositron emission tomography radioligandBrain activationBlood flow increasesVolume of distributionPrimary visual cortexCheckerboard visual stimulationFunctional brain activationFunctional magnetic resonanceReference tissue modelFMRI BOLD responsesSynaptic densityVisual stimulation taskOne-tissue compartment modelHealthy volunteersNeuronal firingTomography radioligandPET scansTissue influxVivo measuresRobust increaseBOLD responseTracer influxStimulation taskPET imaging of mGluR5 in Alzheimer’s disease
Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.Peer-Reviewed Original ResearchConceptsEarly Alzheimer's diseaseAlzheimer's diseaseMild cognitive impairmentBrain amyloidHippocampus of ADPositron emission tomography radioligandSubtype 5 receptorsMild AD dementiaGray matter atrophyAssociation cortical regionsAmnestic mild cognitive impairmentImportant therapeutic targetCerebellum reference regionDynamic PET scansHippocampal mGluR5MethodsSixteen individualsMGluR5 bindingSynaptotoxic actionAD dementiaAD pathogenesisMatter atrophyInitial administrationAD groupSynaptic transmissionEntorhinal cortex
2019
Assessment of a white matter reference region for 11C-UCB-J PET quantification
Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE. Assessment of a white matter reference region for 11C-UCB-J PET quantification. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 1890-1901. PMID: 31570041, PMCID: PMC7446568, DOI: 10.1177/0271678x19879230.Peer-Reviewed Original ResearchImaging histamine H3 receptors with [18F]FMH3: Test–retest and occupancy studies in the non‐human primate
Sandiego CM, Barret O, Lee H, Alagille D, Amenta A, Fowles K, Holden D, Seibyl JP, Tamagnan G. Imaging histamine H3 receptors with [18F]FMH3: Test–retest and occupancy studies in the non‐human primate. Synapse 2019, 73: e22096. PMID: 30835877, DOI: 10.1002/syn.22096.Peer-Reviewed Original ResearchConceptsABT-239Non-human primatesClinical investigationPositron emission tomography radioligandVolume of distributionReceptor subtype 3Histamine H3 receptorsDose-dependent effectAdult female baboonsPET brain scansBrain stemPlasma levelsSleep abnormalitiesBaseline scanH3 receptorsTomography radioligandOccupancy studiesCognitive disordersSubtype 3Brain scansBrain regionsCortical regionsPET studiesCiproxifanBaseline V
2011
Assessing the sensitivity of [11C]p943, a novel 5‐HTIB radioligand, to endogenous serotonin release
Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin S, Staley JK, Bhagwagar Z, Carson RE. Assessing the sensitivity of [11C]p943, a novel 5‐HTIB radioligand, to endogenous serotonin release. Synapse 2011, 65: 1113-1117. PMID: 21484884, PMCID: PMC3149753, DOI: 10.1002/syn.20942.Peer-Reviewed Original ResearchConceptsFenfluramine-induced changesReceptor occupancyDoses of fenfluraminePositron emission tomography radioligandEndogenous serotonin releaseNonhuman primate brainSerotonin releaseLow doseHigh doseTomography radioligandPrimate brainRhesus monkeysFenfluramineRhesus macaquesPET imagingHuman brainBaboonsDoseDosesRadioligandBrainCurrent studyReceptors
2009
PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)‐[11C]O‐methylreboxetine and HRRT
Ding Y, Singhal T, Planeta‐Wilson B, Gallezot J, Nabulsi N, Labaree D, Ropchan J, Henry S, Williams W, Carson RE, Neumeister A, Malison RT. PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)‐[11C]O‐methylreboxetine and HRRT. Synapse 2009, 64: 30-38. PMID: 19728366, PMCID: PMC3727644, DOI: 10.1002/syn.20696.Peer-Reviewed Original Research
1997
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier A, Su T, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2569-2574. PMID: 9122236, PMCID: PMC20129, DOI: 10.1073/pnas.94.6.2569.Peer-Reviewed Original ResearchConceptsSynaptic dopamine concentrationsDopamine concentrationsDopamine outflowDopamine levelsStriatal extracellular dopamine levelsBinding reductionPositron emission tomography radioligandExtracellular dopamine levelsSynaptic dopamine levelsAmphetamine-induced changesNonhuman primate studiesPositron emission tomography (PET) methodDopamine overactivityPatients elevationNovel brain imaging methodVivo microdialysisAmphetamine doseDopamine receptorsClinical studiesDopamine releasePreclinical studiesHealthy volunteersBrain imaging methodsDopamine increasesTomography radioligand
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