2024
Fuel oxygenates
Abu-Bakar A, Vasiliou V, Popovic Z, Inayat-Hussain S. Fuel oxygenates. 2024, 859-874. DOI: 10.1016/b978-0-12-824315-2.00736-3.Peer-Reviewed Original ResearchCentral nervous systemChronic progressive nephropathyRat kidney tumorsOccupational health hazardsNon-toxic dosesProgressive nephropathyRisk factorsKidney tumorsInhalation toxicityNervous systemEye irritationWeight gainToxicology studiesReversible effectHealth hazardsRecent seriesHuman odourNephropathyTumorsKidneyRatsDiseaseMiceLiverDoses
2023
An oral androgen receptor RIPTAC for prostate cancer.
Raina K, Eastman K, Yu X, Forbes C, Jones K, Mousseau J, Li H, Kayser-Bricker K, Crews C. An oral androgen receptor RIPTAC for prostate cancer. Journal Of Clinical Oncology 2023, 41: 184-184. DOI: 10.1200/jco.2023.41.6_suppl.184.Peer-Reviewed Original ResearchPCa cell linesAR expressionProstate cancerAR-positive cellsCastration-resistant settingLow oral doseProstate cancer modelTumor growth inhibitionProstate cancer cellsCell linesEfficacious exposureVCaP xenograftsOral dosePreclinical dataOral dosingLow nM concentrationsTumor-specific inhibitionCancer modelPharmacokinetic propertiesNormal tissuesOral bioavailabilitySignaling InhibitorsToxicology studiesAR geneCancer cellsPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2010
Approaches to Performing Metabolite Elucidation: One Key to Success in Drug Discovery and Development
Nassar A. Approaches to Performing Metabolite Elucidation: One Key to Success in Drug Discovery and Development. 2010, 1-23. DOI: 10.1002/9780470571224.pse108.Peer-Reviewed Original Research
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