2023
The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors
Xu J, Pittenger C. The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors. Journal Of Biological Chemistry 2023, 299: 104583. PMID: 36871761, PMCID: PMC10139999, DOI: 10.1016/j.jbc.2023.104583.Peer-Reviewed Original ResearchConceptsStress-activated protein kinase 1Receptor-dependent signaling pathwaysSerine/threonineGlycogen synthase kinase 3 betaSynthase kinase 3 betaProtein kinase 1Phosphorylation of mitogenBiochemical approachesMolecular mechanismsKinase 1Signaling pathwaysProximity ligationBeta signalingBiochemical levelPhosphorylation levelsReceptorsActivationHistamine H3 receptorsPhosphorylationSignalingThreonineAktSpiny projection neuronsD2R functionBetter understanding
2019
Imaging histamine H3 receptors with [18F]FMH3: Test–retest and occupancy studies in the non‐human primate
Sandiego CM, Barret O, Lee H, Alagille D, Amenta A, Fowles K, Holden D, Seibyl JP, Tamagnan G. Imaging histamine H3 receptors with [18F]FMH3: Test–retest and occupancy studies in the non‐human primate. Synapse 2019, 73: e22096. PMID: 30835877, DOI: 10.1002/syn.22096.Peer-Reviewed Original ResearchConceptsABT-239Non-human primatesClinical investigationPositron emission tomography radioligandVolume of distributionReceptor subtype 3Histamine H3 receptorsDose-dependent effectAdult female baboonsPET brain scansBrain stemPlasma levelsSleep abnormalitiesBaseline scanH3 receptorsTomography radioligandOccupancy studiesCognitive disordersSubtype 3Brain scansBrain regionsCortical regionsPET studiesCiproxifanBaseline V
2007
Modulation of Hippocampal Theta Oscillation by Histamine H3 Receptors
Hajós M, Siok C, Hoffmann W, Li S, Kocsis B. Modulation of Hippocampal Theta Oscillation by Histamine H3 Receptors. Journal Of Pharmacology And Experimental Therapeutics 2007, 324: 391-398. PMID: 17940197, DOI: 10.1124/jpet.107.130070.Peer-Reviewed Original ResearchConceptsReceptor antagonist/inverse agonistHippocampal theta activityAntagonist/inverse agonistHippocampal theta oscillationsH3 receptorsSystemic administrationTheta activityH3 receptor antagonists/inverse agonistsInverse agonistHistamine-induced modulationTheta oscillationsElectrical brainstem stimulationHistamine H3 receptorsField potential recordingsNeuronal network oscillationsHigher brain functionsProcognitive actionsHippocampal theta powerPreclinical findingsBrainstem stimulationHippocampal fissurePolysomnographic recordingsPotential recordingsCognitive functionDelta power
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