2024
From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)
Li T, Feng W, Yan W, Wang T. From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review). Molecular Medicine Reports 2024, 30: 145. PMID: 38904193, DOI: 10.3892/mmr.2024.13269.Peer-Reviewed Original ResearchConceptsTrained immunityTrained macrophagesAbundant immune cellsCharacteristics of innate immunityChronic inflammatory diseaseAtherosclerotic plaquesProgression of ASImmune cellsInflammatory diseasesImmune responseTherapeutic approachesClinical strategiesEpigenetic reprogrammingDeposition of lipoproteinsCardiovascular diseaseInnate immunityMacrophagesAtherosclerosisImmunityDiseasePlaqueCellsComplex mechanisms
2023
The local microenvironment drives activation of neutrophils in human brain tumors
Maas R, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado Á, Marie D, Lilja J, Marcone R, Calvo G, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger A, Brouland J, Daniel R, Hegi M, Joyce J. The local microenvironment drives activation of neutrophils in human brain tumors. Cell 2023, 186: 4546-4566.e27. PMID: 37769657, DOI: 10.1016/j.cell.2023.08.043.Peer-Reviewed Original ResearchTumor-associated neutrophilsHuman brain tumorsBrain tumorsTumor necrosis factor alphaDistinct inflammatory signatureOverall immune suppressionBrain metastasis patientsPro-inflammatory mediatorsSoluble inflammatory mediatorsAbundant immune cellsNecrosis factor alphaActivation of neutrophilsTumor-associated macrophagesPro-angiogenic capacityBrain metastasesInflammatory signatureMetastasis patientsInflammatory mediatorsNeutrophil phenotypeImmune suppressionPeripheral bloodBlood neutrophilsDifferent cancer typesImmune cellsBrain microenvironment
2021
Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study
Zerdes I, Simonetti M, Matikas A, Harbers L, Acs B, Boyaci C, Zhang N, Salgkamis D, Agartz S, Moreno-Ruiz P, Bai Y, Rimm DL, Hartman J, Mezheyeuski A, Bergh J, Crosetto N, Foukakis T. Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study. Npj Breast Cancer 2021, 7: 144. PMID: 34799582, PMCID: PMC8604966, DOI: 10.1038/s41523-021-00352-3.Peer-Reviewed Original ResearchMultiplexed fluorescent immunohistochemistryPhase II trialII trialEarly breast cancer patientsSomatic copy number alterationsCopy number alterationsEarly breast cancerBreast cancer patientsAbundant immune cellsImmune cell compositionParaffin-embedded tissue samplesNumber alterationsImmune profilePD-1PD-L1Immune profilingLymphocytic infiltrationCancer patientsImmune cellsBreast cancerT cellsLarge cohortFluorescent immunohistochemistryTissue samplesPathological samples
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