2023
Society of Anesthesia and Sleep Medicine Position Paper on Patient Sleep During Hospitalization
Hillman D, Carlucci M, Charchaflieh J, Cloward T, Gali B, Gay P, Lyons M, McNeill M, Singh M, Yilmaz M, Auckley D. Society of Anesthesia and Sleep Medicine Position Paper on Patient Sleep During Hospitalization. Anesthesia & Analgesia 2023, 136: 814-824. PMID: 36745563, DOI: 10.1213/ane.0000000000006395.Peer-Reviewed Original ResearchConceptsSociety of AnesthesiaPatients' sleepSleep needSleep medicineCare-related factorsImpact of hospitalizationPatient care guidelinesHealth care providersAssessment of interventionsUrinary dysfunctionMedication withdrawalImmune dysfunctionCardiovascular dysfunctionCare guidelinesVentilatory functionProinflammatory effectsPain perceptionMetabolic dysfunctionPoor sleepPsychomotor disturbanceSleep disordersCare providersSleep durationStaff educationHospitalization
2020
Complement Membrane Attack Complex New Roles, Mechanisms of Action, and Therapeutic Targets
Xie CB, Jane-Wit D, Pober JS. Complement Membrane Attack Complex New Roles, Mechanisms of Action, and Therapeutic Targets. American Journal Of Pathology 2020, 190: 1138-1150. PMID: 32194049, PMCID: PMC7280757, DOI: 10.1016/j.ajpath.2020.02.006.Peer-Reviewed Original ResearchConceptsMembrane attack complexMAC assemblyExpression of inhibitorMechanism of actionFacilitate secretionDependent transcriptionPlasma membraneIntracellular signalingComplement membrane attack complexAbsence of lysisSignalingRecent insightsBiophysical propertiesComplement-mediated diseasesAttack complexTherapeutic targetCell activationDisease pathogenesisAdaptive immunityNew roleIL-18IL-1βCytolytic effectorsProinflammatory effectsProinflammatory proteins
2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention
2005
The Kallikrein-Kinin System: Current and Future Pharmacological Targets
Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A. The Kallikrein-Kinin System: Current and Future Pharmacological Targets. Journal Of Pharmacological Sciences 2005, 99: 6-38. PMID: 16177542, DOI: 10.1254/jphs.srj05001x.Peer-Reviewed Original ResearchMeSH KeywordsAngioedemaAngiotensin-Converting Enzyme InhibitorsAnimalsAprotininBradykininBradykinin B2 Receptor AntagonistsCardiovascular DiseasesComplement C1 Inactivator ProteinsComplement C1 Inhibitor ProteinHumansInflammationKallikrein-Kinin SystemKallikreinsKidney DiseasesKininsNeprilysinPeptidyl-Dipeptidase APolymorphism, GeneticPyridinesRandomized Controlled Trials as TopicReceptor, Bradykinin B1Receptor, Bradykinin B2SerpinsThiazepinesConceptsKallikrein-kinin systemMultiple pharmacological interventionsPrecursors of kininsFuture pharmacological targetsProinflammatory effectsVasoactive kininsPharmacological interventionsCardiovascular propertiesPharmacological targetsComplement pathwayKininsActive kininsPathological processesPharmacological activitiesPlasma kallikreinMetabolic cascadeImportant metabolic pathwaysMetabolic pathwaysAntiproteases
1998
Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.
Cuff C, Schwartz J, Bergman C, Russell K, Bender J, Ruddle N. Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development. The Journal Of Immunology 1998, 161: 6853-60. PMID: 9862717, DOI: 10.4049/jimmunol.161.12.6853.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesChemokine CCL2Chemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL2ChemokinesChemokines, CXCCytotoxicity, ImmunologicEmbryonic and Fetal DevelopmentE-SelectinGene Expression RegulationHumansImmunoglobulinsInflammationIntercellular Adhesion Molecule-1Lymphoid TissueLymphotoxin-alphaMacrophage Inflammatory ProteinsMiceMonokinesMucoproteinsRecombinant Fusion ProteinsSpecies SpecificityStimulation, ChemicalTumor Cells, CulturedVascular Cell Adhesion Molecule-1ConceptsLymphoid organ developmentMAdCAM-1LT-alphaLT alpha3Adhesion moleculesTreatment periodIFN-inducible protein-10Biologic activityInduction of chemokinesChemotactic protein-1Peripheral node addressinCellular adhesion moleculesMucosal addressin MAdCAM-1Unique biologic activityInflammatory mediatorsChemokine expressionProinflammatory effectsLymphoid tissueMTNF-alphaMaximal killingChemokine RANTESE-selectinKnockout miceProtein 10Alpha preparations
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