2020
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nature Communications 2020, 11: 5981. PMID: 33239628, PMCID: PMC7689490, DOI: 10.1038/s41467-020-19764-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsAntigens, CDAtherosclerosisBinding SitesCarotid Artery, CommonChemokine CXCL12Crystallography, X-RayDisease Models, AnimalDrug DesignDrug Evaluation, PreclinicalEndarterectomy, CarotidFemaleHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMiceMice, Knockout, ApoEMiddle AgedPeptide FragmentsReceptors, CXCR4SialyltransferasesSignal TransductionConceptsMacrophage migration inhibitory factorCXC motif chemokine receptor 4Chemokine receptorsChemokine/receptor axisCXCR4/CXCL12 interactionHuman carotid endarterectomy specimensMigration inhibitory factorChemokine receptor 4MIF/CD74Carotid endarterectomy specimensAtherogenic inflammationCXCL12 interactionReceptor axisReceptor 4MIF inhibitorsReceptor-based strategiesAtherosclerotic plaquesAtherosclerosisAtypical chemokineLeukocyte adhesionCell activityProtective pathwaysInflammationChemokinesPlaques
2016
Breast cancer and social environment: getting by with a little help from our friends
Hinzey A, Gaudier-Diaz M, Lustberg M, DeVries A. Breast cancer and social environment: getting by with a little help from our friends. Breast Cancer Research 2016, 18: 54. PMID: 27225892, PMCID: PMC4881170, DOI: 10.1186/s13058-016-0700-x.Peer-Reviewed Original ResearchConceptsTumor growthBreast cancerBreast cancer survivorsBreast cancer patientsIdentification of patientsCancer-related mortalityMammary tumor growthBreast cancer progressionBasic science literatureInadequate social supportTherapeutic complementCancer survivorsPoor outcomeCancer patientsTumor progressionProtective pathwaysContemporary treatmentDetrimental pathwaysCancer progressionTargeted disruptionUnderlying physiological mechanismsSocial isolationPatientsCancerSocial support
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply