2023
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Zhang W, Zhao X, Qi X, Kimber S, Hooper N, Wang T. Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Frontiers In Cellular Neuroscience 2023, 17: 1195470. PMID: 37361999, PMCID: PMC10285224, DOI: 10.3389/fncel.2023.1195470.Peer-Reviewed Original ResearchBrain microvascular endothelial-like cellsTransendothelial electrical resistanceCerebral autosomal dominant arteriopathyAutosomal dominant arteriopathyCADASIL patientsNeurovascular interactionsMural cellsNeurovascular unitSubcortical infarctsBlood-brain barrier functionPluripotent stem cell modelsBarrier functionBrain MRI lesionsSmall vessel diseaseBrain barrier functionCortical projection neuronsStem cell modelWild-type astrocytesFuture therapeutic developmentNVU cell typesVascular mural cellsEarly disease pathologyInduced Pluripotent Stem Cell ModelRecurrent strokeCell types
2015
Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts
Johnson ME, Mahoney JM, Taroni J, Sargent JL, Marmarelis E, Wu MR, Varga J, Hinchcliff ME, Whitfield ML. Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts. PLOS ONE 2015, 10: e0114017. PMID: 25607805, PMCID: PMC4301872, DOI: 10.1371/journal.pone.0114017.Peer-Reviewed Original ResearchConceptsNormal-like subsetsGenome-wide expression profilingSet of genesDifferential gene expressionDistinct signaling pathwaysInflammatory subsetSystemic sclerosisGene signatureIndependent cohortGene expression signaturesLipid signalingInnate immune pathwaysActive TGFβ signalingExpression profilingSystemic sclerosis patientsMolecular relationshipsGene expressionNon-lesional skinTGFβ signalingSignaling pathwaysSubsets of diseaseMolecular pathwaysMicroarray datasetsExpression signaturesEarly disease pathology
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