2019
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams A, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt M, Lakkis F. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Journal Of Clinical Investigation 2019, 130: 287-294. PMID: 31763998, PMCID: PMC6934226, DOI: 10.1172/jci125773.Peer-Reviewed Original ResearchConceptsHost DCT cell responsesDonor antigensT cellsMHC-peptide complexesActivation of host T cellsAlloantigens to T cellsEffector T cell responsesCD8+ T cellsDonor MHC moleculesHost T cellsDifferentiation to effectorKidney transplant modelSecondary lymphoid organsSelf-MHC moleculesAntigen presentation pathwayAcute rejectionAllograft rejectionDendritic cellsIndirect presentationTransplantation modelAntigen presentationLymphoid organsPresentation pathwayIntravital microscopy
2017
Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation
Tahvildari M, Emami-Naeini P, Omoto M, Mashaghi A, Chauhan S, Dana R. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation. Scientific Reports 2017, 7: 971. PMID: 28428556, PMCID: PMC5430534, DOI: 10.1038/s41598-017-01065-z.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHigh-risk corneal transplantationCorneal transplantationDonor corneasGraft survivalT cellsMouse model of corneal transplantationTissue-resident antigen-presenting cellsModel of corneal transplantationTolerogenic antigen-presenting cellsGraft bedImmature antigen-presenting cellsMigrate to lymphoid tissuesCorneal allograft recipientsCorneal allograft survivalDonor corneal stromaInflamed graft bedsDonor corneal tissueTransforming growth factor-b1Effector T cellsCD4+ cellsHost T cellsPromote graft survivalSaline-injected controlsGraft infiltration
2013
PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease
Juchem K, Anderson B, Zhang C, Sharpe A, McNiff J, Demetris A, Shlomchik M, Shlomchik W. PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease. Blood 2013, 122: 4479. DOI: 10.1182/blood.v122.21.4479.4479.Peer-Reviewed Original ResearchDonor bone marrowPD-L1PD-L1/2T cellsBone marrowLate weight lossWeight lossHost diseasePD-1Graft Versus Host DiseaseInhibitory molecules PD-1Effector memory T cellsT cell receptor transgenic modelAllogeneic stem cell transplantationT-cell-mediated pathogenesisMore chronic phasesPD-L1/2 expressionRadioresistant stromal cellsDays post transplantHost T cellsCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsEarly weight loss
2007
Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse
Durakovic N, Radojcic V, Skarica M, Bezak K, Powell J, Fuchs E, Luznik L. Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood 2007, 109: 4564-4574. PMID: 17227829, PMCID: PMC1885486, DOI: 10.1182/blood-2006-09-048124.Peer-Reviewed Original ResearchConceptsDonor lymphocyte infusionDonor T cellsHost T cellsBone marrow transplantationT cellsHost chimerismHost APCsMarrow transplantationPrevious sensitizationAllogeneic bone marrow transplantationToll-like receptor ligandsGvH responseGVL reactivityLeukemia reactivityLymphocyte infusionMixed chimerismTLR ligandsHost antigensMurine modelVivo administrationCell activatorsHigh levelsAlloreactivityChimerismMHC
1999
HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-β
Smith D, Buckle G, Hafler D, Frank D, Höllsberg P. HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-β. Virology 1999, 257: 314-321. PMID: 10329542, DOI: 10.1006/viro.1999.9679.Peer-Reviewed Original ResearchConceptsT cell clonesIFN-betaT cellsAntiproliferative actionHuman T-cell lymphotropic virus type IMyelopathy/tropical spastic paraparesisLymphotropic virus type INormal immunoregulatory mechanismsInnate immune defense mechanismsHost T cellsExogenous IL-2Tropical spastic paraparesisT cell proliferationImmune defense mechanismsVirus type IT cell activationPathogenesis of HTLVImmunoregulatory mechanismsSpastic paraparesisIL-2Phosphorylation of STAT1IFN-gammaViral infectionHigh dosesHTLV
1994
Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28.
Karmann K, Pober JS, Hughes CC. Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. The Journal Of Immunology 1994, 153: 3929-37. PMID: 7523510, DOI: 10.4049/jimmunol.153.9.3929.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cellsEndothelial cellsPeripheral blood T cellsHuman peripheral blood T cellsGraft endothelial cellsHost T cellsBlood T cellsT cell CD28Cultured human endothelial cellsEndothelial cell ligandsIL-2 synthesisInitiation of cocultureContact-dependent interactionsEffect of ECHuman endothelial cellsT cell CD2Presence of ECInhibitory doseLFA-3Cell ligandsCyclosporin ACD28Cell contactSecretion
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