2024
Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses
Fogaça M, Daher F, Picciotto M. Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses. Neuropsychopharmacology 2024, 50: 673-684. PMID: 39390105, PMCID: PMC11845475, DOI: 10.1038/s41386-024-02002-1.Peer-Reviewed Original ResearchNovelty suppressed feeding testMedial prefrontal cortexSucrose splash testEffects of ketamineAntidepressant-like responseMajor depressive disorderGABAergic activityGABA interneuronsGlutamatergic activityGABA neuronsSustained antidepressant effectsGABA neuron activityLow dose of ketamineAdministration of ketamineDose of ketamineAntidepressant responseAntidepressant developmentSplash testAntidepressant effectsPrefrontal cortexDepressive disorderChemogenetic inhibitionBehavioral actionsAssociated with disruptionGABA function
2020
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain 2020, 8: 100049. PMID: 32548337, PMCID: PMC7284072, DOI: 10.1016/j.ynpai.2020.100049.Peer-Reviewed Original ResearchHyperalgesic primingPlantar incisionFemale miceBasolateral nucleusHyperalgesic priming modelSucrose splash testSex differencesPain-related behaviorsIntra-BLA microinjectionGluA2-containing AMPA receptorsDistinct brain regionsMechanical hypersensitivityPain mechanismsAberrant behavioral responsesChronic painFacial grimacingBody of evidenceMale miceSplash testPain unpleasantnessProstaglandin EAMPA receptorsGluA2 expressionUnderlying neural mechanismsBrain regions
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