2023
Bridging Scales in Black Hole Accretion and Feedback: Magnetized Bondi Accretion in 3D GRMHD
Cho H, Prather B, Narayan R, Natarajan P, Su K, Ricarte A, Chatterjee K. Bridging Scales in Black Hole Accretion and Feedback: Magnetized Bondi Accretion in 3D GRMHD. The Astrophysical Journal Letters 2023, 959: l22. DOI: 10.3847/2041-8213/ad1048.Peer-Reviewed Original ResearchSupermassive black holesStrong magnetic fieldMagnetic fieldBondi rateAccretion rateOrders of magnitudeBlack hole accretionMagnetic field reconnectionLow accretion ratesEnergy feedbackHost galaxiesSMBH massGas accretionField reconnectionBondi accretionBondi problemBondi radiusHorizon scaleBlack holesDensity profilesEnergy transportAccretionTurbulent convectionExternal mediumDisparate scalesA persistent excess of galaxy-galaxy strong lensing observed in galaxy clusters
Meneghetti M, Cui W, Rasia E, Yepes G, Acebron A, Angora G, Bergamini P, Borgani S, Calura F, Despali G, Giocoli C, Granata G, Grillo C, Knebe A, Macciò A, Mercurio A, Moscardini L, Natarajan P, Ragagnin A, Rosati P, Vanzella E. A persistent excess of galaxy-galaxy strong lensing observed in galaxy clusters. Astronomy & Astrophysics 2023, 678: l2. DOI: 10.1051/0004-6361/202346975.Peer-Reviewed Original ResearchGalaxy clustersObserved galaxy clustersStrong lensingCold dark matter cosmological modelCosmological modelsDense stellar coreGalaxy formation modelsCosmological hydrodynamical simulationsStandard cosmological modelDifferent observational propertiesRay-tracing analysisCluster galaxiesStar formationIntracluster mediumStellar coreHydrodynamical simulationsObservational propertiesGalaxiesLensingOrders of magnitudeSame initial conditionsNumerical implementationFormation modelTheoretical predictionsInitial conditions
2022
Introduction to Charged Lepton Flavor Violation
Ardu M, Pezzullo G. Introduction to Charged Lepton Flavor Violation. Universe 2022, 8: 299. DOI: 10.3390/universe8060299.Peer-Reviewed Original ResearchLepton flavor violationCurrent best limitsFlavor violationModels of physicsBest limitUpcoming experimentsNeutrino massesBSM theoriesExperimental searchStringent constraintsStandard modelOrders of magnitudeParameter spaceCLFVLeptonsPhysicsViolationNext generationSpectraCalculationsLimitExperimentsParticular emphasisMass
2021
NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data
He L, Davila-Velderrain J, Sumida TS, Hafler DA, Kellis M, Kulminski AM. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications Biology 2021, 4: 629. PMID: 34040149, PMCID: PMC8155058, DOI: 10.1038/s42003-021-02146-6.Peer-Reviewed Original ResearchConceptsNegative binomial mixed modelsBinomial mixed modelsSingle-cell dataHigh-dimensional integralsLarge sample approximationLaplace approximationCell-level expressionMixed modelsApproximationNebulaSpeed gainData setsOrders of magnitudeMarker gene identificationIntegralsModelOverdispersionFalse positive errorsHuman kidney stones: a natural record of universal biomineralization
Sivaguru M, Saw J, Wilson E, Lieske J, Krambeck A, Williams J, Romero M, Fouke K, Curtis M, Kear-Scott J, Chia N, Fouke B. Human kidney stones: a natural record of universal biomineralization. Nature Reviews Urology 2021, 18: 404-432. PMID: 34031587, DOI: 10.1038/s41585-021-00469-x.Peer-Reviewed Original ResearchConceptsHot spring depositsCalcium-rich mineralsFields of geologyFundamental natural processesBillions of yearsDisequilibrium precipitationParagenetic sequenceConcentric zoningDeep subsurfaceNatural recordsSector zoneRoman aqueductCoral reefsNatural processesBroad length scalesCrystal aggregatesIndividual stonesHydroxyapatite spherulesThermodynamic energeticsOrders of magnitudeNew transdisciplinary approachDissolutionTotal volumeRecrystallizationStratigraphyStatistical Methods for Analyzing Tree-Structured Microbiome Data
Wang T, Zhao H. Statistical Methods for Analyzing Tree-Structured Microbiome Data. Frontiers In Probability And The Statistical Sciences 2021, 193-220. DOI: 10.1007/978-3-030-73351-3_8.Peer-Reviewed Original ResearchStatistical methodsOnly relative informationMicrobiome data analysisMicrobiome dataEmpirical Bayes estimationCompositional predictorsBayes estimationComputational challengesRelative informationDimension reductionAbundance matrixTaxa countsMultinomial modelMicrobiome datasetsPhylogenetic informationMicrobial taxaPhylogenetic treeSequencing technologiesOriginal ecosystemMicrobial compositionOrders of magnitudeMatrixExperimental methodsLibrary sizeZerosUltrahigh-speed point scanning two-photon microscopy using high dynamic range silicon photomultipliers
Ching-Roa VD, Olson EM, Ibrahim SF, Torres R, Giacomelli MG. Ultrahigh-speed point scanning two-photon microscopy using high dynamic range silicon photomultipliers. Scientific Reports 2021, 11: 5248. PMID: 33664354, PMCID: PMC7933192, DOI: 10.1038/s41598-021-84522-0.Peer-Reviewed Original ResearchConceptsMaximum imaging rateSilicon photomultipliersAdvanced detection technologyPhoton detection rateDetection electronicsDetection technologyTwo-photon microscopyHigh sensitivityPhotomultiplier tubeDynamic rangeMicroscopyTwo-photon microscopeNoise ratioImaging rateOrders of magnitudeTwo-photonIntegration timeDetector designElectronicsPhotomultipliersMicroscopeConfocal microscopyTubeTechnologyDetection rate
2020
Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations
Hoogerheide D, Rostovtseva T, Jacobs D, Gurnev P, Bezrukov S. Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations. ACS Nano 2020, 15: 989-1001. PMID: 33369404, PMCID: PMC9019845, DOI: 10.1021/acsnano.0c07672.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelMembrane surfaceSingle-molecule levelSame membrane surfaceIndividual proteinsAnion channelNeuronal proteinsLipid membranesBinding conformationsLipid surfaceLipid compositionProteinΑ-synucleinMembraneConformationOrders of magnitudeSurfaceUnbindingMitochondriaBindsObserved distributionNanoporesMoleculesΑSynTrapsAn excess of small-scale gravitational lenses observed in galaxy clusters
Meneghetti M, Davoli G, Bergamini P, Rosati P, Natarajan P, Giocoli C, Caminha G, Metcalf R, Rasia E, Borgani S, Calura F, Grillo C, Mercurio A, Vanzella E. An excess of small-scale gravitational lenses observed in galaxy clusters. Science 2020, 369: 1347-1351. PMID: 32913099, DOI: 10.1126/science.aax5164.Peer-Reviewed Original ResearchCold dark matterDark matterGalaxy clustersDark matter substructureStrong lensing eventsProperties of substructuresLuminous matterEfficient lensesCosmological simulationsCDM simulationsGravitational lensingGravitational lensesLensing eventsCluster substructureCosmic environmentOrders of magnitudeLensingUniverseLensesMatterSubstructureClustersSimulationsPropertiesSystematic issuesTransforming FIB-SEM Systems for Large-Volume Connectomics and Cell Biology
Xu C, Pang S, Hayworth K, Hess H. Transforming FIB-SEM Systems for Large-Volume Connectomics and Cell Biology. Neuromethods 2020, 155: 221-243. DOI: 10.1007/978-1-0716-0691-9_12.Peer-Reviewed Original ResearchScanning electron microscopy systemIon beam scanning electron microscopyBeam scanning electron microscopyElectron microscopy systemScanning electron microscopyElectron microscopyLong-term reliabilityScanning electron microscopy technologyRobust imaging platformElectron microscopy technologyConventional FIBMicroscopy systemHigh resolutionFIB-SEMResolution requirementsCell biology researchBoundary conditionsFinal image stackFIBMicroscopy technologyHigh-resolution imagingOrders of magnitudeImaging platformLarge sample volumesImage volumesDesign and status of the Mu2e crystal calorimeter
Atanov N, Baranov V, Bloise C, Budagov J, Cervelli F, Ceravolo S, Colao F, Cordelli M, Corradi G, Davydov Y, Di Falco S, Diociaiuti E, Donati S, Donghia R, Echenard B, Ferrari C, Giovannella S, Glagolev V, Grancagnolo F, Hampai D, Happacher F, Hitlin D, Martini M, Miscetti S, Miyashita T, Morescalchi L, Murat P, Pasciuto D, Pedreschi E, Pezzullo G, Porter F, Raffaelli F, Saputi A, Sarra I, Spinella F, Tassielli G, Tereshchenko V, Usubov Z, Vasilyev I, Zanetti A, Zhu R. Design and status of the Mu2e crystal calorimeter. Nuclear Instruments And Methods In Physics Research Section A Accelerators Spectrometers Detectors And Associated Equipment 2020, 958: 162140. DOI: 10.1016/j.nima.2019.04.094.Peer-Reviewed Original ResearchLarge area silicon photomultipliersExcellent particle identification capabilitiesParticle identification capabilitiesMono-energetic electronsTrack reconstruction capabilityPure CsI crystalsCoherent neutrinoCosmic raysNew physicsCrystal calorimeterCoulomb fieldElectron beamMu2e experimentElectron conversionElectromagnetic calorimeterSilicon photomultipliersClear signatureLepton flavorAluminum nucleiCsI crystalsStandard modelSearch sensitivityDistinctive signatureOrders of magnitudeLarge-scale prototype
2019
Plastic Deformation and Fragmentation of Strained Actin Filaments
Schramm AC, Hocky GM, Voth GA, Martiel JL, De La Cruz EM. Plastic Deformation and Fragmentation of Strained Actin Filaments. Biophysical Journal 2019, 117: 453-463. PMID: 31301801, PMCID: PMC6697348, DOI: 10.1016/j.bpj.2019.06.018.Peer-Reviewed Original Research
2018
Final design and current status of the Mu2e crystal calorimeter
Atanov N, Baranov V, Budagov J, Cervelli F, Colao F, Diociaiuti E, Cordelli M, Corradi G, Davydov Y, Donghia R, Di Falco S, Echenard B, Morescalchi L, Giovannella S, Glagolev V, Grancagnolo F, Happacher F, Hitlin D, Martini M, Miscetti S, Miyashita T, Morescalchi L, Murat P, Pedreschi E, Pezzullo G, Porter F, Raffaelli F, Ricci M, Saputi A, Sarra I, Spinella F, Tassielli G, Tereshchenko V, Zhu R. Final design and current status of the Mu2e crystal calorimeter. 2018, 00: 1-4. DOI: 10.1109/nssmic.2018.8824316.Peer-Reviewed Original ResearchMu2e experimentNeutrino-less conversionMono-energetic electronsSingle event sensitivityFront-end electronicsRest massCrystal calorimeterCalorimeter prototypeParticle identificationLaboratory searchesSilicon photomultipliersNegative muonsAluminum nucleiCsI crystalsEvent sensitivityOrders of magnitudeElectronsPrevious experimentsCrystalsCalorimeterMuonsINFNPhotomultipliersDetectorPhotosensorsThe Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin
Santos-Sacchi J, Tan W. The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. Journal Of Neuroscience 2018, 38: 5495-5506. PMID: 29899032, PMCID: PMC6001036, DOI: 10.1523/jneurosci.0425-18.2018.Peer-Reviewed Original ResearchConceptsFrequency responseVoltage excitationNonlinear capacitanceFlat frequency responseLow-pass behaviorInterrogation frequencyMechanical responsePiezoelectric couplingCutoff frequencyLow-pass characteristicsLow passElectrical signatureLimiting timeOrders of magnitudeAmplification gainCochlear amplificationKHzΜsMembrane protein prestinVoltageKineticsCapacitanceDamage resultsPhase correspondsElectrical
2017
Nanopatterned Bulk Metallic Glass Biosensors
Kinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S, Legassey A, Loye A, Balestrini J, Solly DA, Schroers J, Taylor A, Papadimitrakopoulos F, Herzog RI, Kyriakides TR. Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors 2017, 2: 1779-1787. PMID: 29115132, DOI: 10.1021/acssensors.7b00455.Peer-Reviewed Original ResearchConceptsCyclic voltammetrySensitivity of biosensorsGlucose oxidase enzymeGlucose biosensor performanceBiocompatible biosensorSurface area enhancementBiosensor performanceElectrochemical measurementsElectrode sensitivityPt-BMGElectrode applicationsBiosensorOxidase enzymeVoltammetryBiocompatible materialsElectrodeΜA/Flat electrodesPlatinum-based bulk metallic glassArea enhancementControl electrodesBulk metallic glassOrders of magnitudeElectrical propertiesLow temperatureProbing Large-scale Coherence between Spitzer IR and Chandra X-Ray Source-subtracted Cosmic Backgrounds
Cappelluti N, Arendt R, Kashlinsky A, Li Y, Hasinger G, Helgason K, Urry M, Natarajan P, Finoguenov A. Probing Large-scale Coherence between Spitzer IR and Chandra X-Ray Source-subtracted Cosmic Backgrounds. The Astrophysical Journal Letters 2017, 847: l11. DOI: 10.3847/2041-8213/aa8acd.Peer-Reviewed Original ResearchBlack holesChandra Deep Field SouthDirect collapse black holesHard X-ray bandHubble Deep Field NorthDeep Field SouthX-ray bandPrimordial black holesSurface brightness fluctuationsEarly black holesCosmic infrared backgroundLarge angular scalesChandra dataCosmic backgroundCross-power spectrumInterstellar mediumAEGIS fieldInfrared backgroundAngular scalesBrightness fluctuationsLarge-scale coherenceOrders of magnitudeNew measurementsFirst detectionNew observationsSignificant Performance Enhancement of Polymer Resins by Bioinspired Dynamic Bonding
Seo S, Lee DW, Ahn JS, Cunha K, Filippidi E, Ju SW, Shin E, Kim B, Levine ZA, Lins RD, Israelachvili JN, Waite JH, Valentine MT, Shea JE, Ahn BK. Significant Performance Enhancement of Polymer Resins by Bioinspired Dynamic Bonding. Advanced Materials 2017, 29 PMID: 28833661, PMCID: PMC5640498, DOI: 10.1002/adma.201703026.Peer-Reviewed Original ResearchMineral surfacesMussel foot proteinsMolecular dynamics simulationsMetal coordinationPolymer networksPolymeric interfacesPriming layerLoad-bearing materialsCatechol groupsDynamic bondingPolymer resinDynamics simulationsFoot proteinsHydrophobic bondsToughness enhancementAdhesion strengthAdhesive primerBondingSignificant performance enhancementSecondary surfacePerformance enhancementOrders of magnitudeSurfaceResinBonds
2016
Solvent Dependence of Lateral Charge Transfer in a Porphyrin Monolayer
Brennan B, Regan K, Durrell A, Schmuttenmaer C, Brudvig G. Solvent Dependence of Lateral Charge Transfer in a Porphyrin Monolayer. ACS Energy Letters 2016, 2: 168-173. DOI: 10.1021/acsenergylett.6b00583.Peer-Reviewed Original ResearchPropylene carbonateRedox-active monolayerCharge transfer kineticsAqueous solvent mixturesCharge transfer mechanismLateral charge transferLateral charge transportPorphyrin monolayersPorphyrin systemsCharge transferSolvent dependenceInfluence of waterSolar energy harvestingSolvent mixturesCharge transportSolventHole hoppingPacking dynamicsMonolayersOrders of magnitudeCarbonateNsSolvationWater
2015
Characterization and Analysis of Liquid Waste from Marcellus Shale Gas Development
Shih JS, Saiers JE, Anisfeld SC, Chu Z, Muehlenbachs LA, Olmstead SM. Characterization and Analysis of Liquid Waste from Marcellus Shale Gas Development. Environmental Science And Technology 2015, 49: 9557-9565. PMID: 26140412, DOI: 10.1021/acs.est.5b01780.Peer-Reviewed Original ResearchConceptsWastewater treatment plantsRelevant water qualityWastewater characteristicsHydraulic fracturingShale gas developmentLiquid wasteDilution of brineMonitoring limitsTreatment plantsDrilling wastesEffluent limitsGas productionWastewaterMarcellus Shale gas developmentOrders of magnitudeWastewater samplesGas developmentWasteMarcellus brinesWater qualityBrineFlowbackSoluble constituentsFracturingDifferent chemicalLow spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging
Redding B, Cerjan A, Huang X, Lee ML, Stone AD, Choma MA, Cao H. Low spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1304-1309. PMID: 25605946, PMCID: PMC4321308, DOI: 10.1073/pnas.1419672112.Peer-Reviewed Original ResearchConceptsLow spatial coherenceFull-field imagingLight-emitting diodesSpatial coherenceSemiconductor lasersLaser sourceLight sourceConventional laser sourcesThermal light sourceIncoherent light sourceHigh spectral radianceIndependent spatial modesCavity laserLaser resonatorCoherent artifactsSample illuminationSpatial modesProjection applicationsIllumination sourceLaserEmitting diodesOrders of magnitudeSpectral radianceThermal sourceHigh power
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