2025
Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell
Bai J, Zhang C, Bahader I, Strenzke N, Renigunta V, Oliver D, Navaratnam D, Beckstein O, Santos-Sacchi J. Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell. Structure 2025 PMID: 40403717, DOI: 10.1016/j.str.2025.04.019.Peer-Reviewed Original Research
2021
Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point
Santos-Sacchi J, Tan WJT. Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point. Hearing Research 2021, 423: 108373. PMID: 34776274, PMCID: PMC9054947, DOI: 10.1016/j.heares.2021.108373.Peer-Reviewed Original ResearchConceptsOperating voltage rangeFrequency responseAC voltage excitationSlow frequency responseVoltage operating pointNonlinear capacitanceOperating voltageOperating pointVoltage excitationVoltage rangeSpecial Issue Outer hair cellJoseph Santos-SacchiVoltageKumar NavaratnamLoadVoltage-sensor charge movement
2020
Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension
Santos-Sacchi J, Tan W. Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension. Scientific Reports 2020, 10: 6222. PMID: 32277153, PMCID: PMC7148382, DOI: 10.1038/s41598-020-63201-6.Peer-Reviewed Original Research
2018
The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin
Santos-Sacchi J, Tan W. The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. Journal Of Neuroscience 2018, 38: 5495-5506. PMID: 29899032, PMCID: PMC6001036, DOI: 10.1523/jneurosci.0425-18.2018.Peer-Reviewed Original ResearchConceptsFrequency responseVoltage excitationNonlinear capacitanceFlat frequency responseLow-pass behaviorInterrogation frequencyMechanical responsePiezoelectric couplingCutoff frequencyLow-pass characteristicsLow passElectrical signatureLimiting timeOrders of magnitudeAmplification gainCochlear amplificationKHzΜsMembrane protein prestinVoltageKineticsCapacitanceDamage resultsPhase correspondsElectrical
1999
Auditory collusion and a coupled couple of outer hair cells
Zhao H, Santos-Sacchi J. Auditory collusion and a coupled couple of outer hair cells. Nature 1999, 399: 359-362. PMID: 10360573, DOI: 10.1038/20686.Peer-Reviewed Original Research
1992
Direct digitization of optical images using a photostimulable phosphor system
Dobbins J, Chotas H, Benveniste H. Direct digitization of optical images using a photostimulable phosphor system. Medical Physics 1992, 19: 1071-1080. PMID: 1518470, DOI: 10.1118/1.596917.Peer-Reviewed Original ResearchConceptsOptical imagesX-ray imaging propertiesX-ray fieldOptical density responsePhosphor systemPhotostimulable phosphor systemHigh optical densityOptical techniquesIncident lightSpatial frequency responseTransparent objectsImaging propertiesSpatial uniformityDensity responseFourier filteringOptical densityProjection techniqueDirect digitizationFrequency responseTable correctionLow densityDensityImage noiseSpatial enhancementLight
1991
Applications of nuclear magnetic cross‐relaxation spectroscopy to tissues
Grad J, Mendelson D, Hyder F, Bryant R. Applications of nuclear magnetic cross‐relaxation spectroscopy to tissues. Magnetic Resonance In Medicine 1991, 17: 452-459. PMID: 2062216, DOI: 10.1002/mrm.1910170216.Peer-Reviewed Original ResearchConceptsCross-relaxation spectroscopyFundamental relaxation timeMagnetic imagingMagnetic imagesMagnetic relaxationDecay constantsAqueous heterogeneous systemsRelaxation timeWater spinsSpinNMR spectraRelaxationFrequency responseSpectroscopySpectraExperimental approachSignal intensitySystem mixtureIntensityConstantsImaging
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