2022
Blue light potentiates safety and bactericidal activity of p-Toluquinone
Wang S, Wong K, Li Y, Ishii M, Li X, Wei L, Lu M, Wu M. Blue light potentiates safety and bactericidal activity of p-Toluquinone. Journal Of Photochemistry And Photobiology B Biology 2022, 230: 112427. PMID: 35338920, DOI: 10.1016/j.jphotobiol.2022.112427.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceBacterial infectionsBactericidal activityE. coli infectionHospital-acquired infectionsMDR bacterial infectionsMDR Escherichia coliNon-specific natureColi infectionCombinatory therapyOxygen species generationInfectionScratch woundBrief exposureEnterococcus faecalisSpecies generationKilling efficacyOpposite effectRecurrenceTherapy
2015
Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens
Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch M. Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens. Microbiology And Molecular Biology Reviews 2015, 79: 101-116. PMID: 25652543, PMCID: PMC4402963, DOI: 10.1128/mmbr.00039-14.Peer-Reviewed Original ResearchConceptsMDR infectionsPublic health threatMultiple drug resistanceHigh prevalenceMore effective interventionsDifferent underlying mechanismsMultidrug resistanceEffective interventionsHealth threatUnderlying mechanismInfectionBacterial pathogensMDRCommon mechanismDifferent pathogensProliferationPathogensPrevalenceHypothetical mechanism
2011
Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy
Colijn C, Cohen T, Ganesh A, Murray M. Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy. PLOS ONE 2011, 6: e18327. PMID: 21479171, PMCID: PMC3068161, DOI: 10.1371/journal.pone.0018327.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceDrug resistanceInitial treatment regimensTB control programsAnti-TB drugsDrug-resistant formsEmergence of resistanceFunctional monotherapyTreatment regimensCombination therapyTB strainsTuberculosis treatmentTherapy rangeM. tbTB bacilliMultidrug resistanceM. tuberculosisDifferent antibioticsTherapyTuberculosisInfected hostControl programsResistant formsTBMonotherapy
2007
Tuberculosis, drug resistance, and HIV/AIDS: A triple threat
Friedland G. Tuberculosis, drug resistance, and HIV/AIDS: A triple threat. Current Infectious Disease Reports 2007, 9: 252-261. PMID: 17430708, DOI: 10.1007/s11908-007-0039-7.Peer-Reviewed Original ResearchTB drug resistanceHIV/AIDSDrug-resistant tuberculosisDrug resistanceTB control programsRapid molecular diagnostic techniquesMultiple drug resistanceAvailable diagnostic technologiesMolecular diagnostic techniquesTB diagnosisWorldwide epidemicTreatment successTherapeutic strategiesTuberculosisTherapeutic agentsAIDSThird epidemicTreatmentDiagnosisDiagnostic techniquesControl programsDiagnostic technologiesEpidemicTriple threatUrgent need
2000
Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.
Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesColchicineDrug Resistance, MultipleFlow CytometryHumansMiceMice, Inbred BALB CModels, TheoreticalNeuroblastomaRatsRats, NudeTissue DistributionTomography, Emission-ComputedTransplantation, HeterologousTumor Cells, CulturedConceptsResistant tumorsPET imagingMultiple drug resistance phenotypeDrug-resistant variantsQuality of lifeCell linesMultiple drug resistanceResistant cell linesC cell lineP-gp actionDrug resistance phenotypeEarly diagnosisNude ratsFDG scansTumorsP-glycoproteinDrug resistanceBiodistribution experimentsCytotoxic agentsChemotherapeutic interventionResistant strainsCancer cellsIntracellular accumulationVivo experimentsScans
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