2013
Osteocytes remove and replace perilacunar mineral during reproductive cycles
Wysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54: 230-236. PMID: 23352996, PMCID: PMC3624069, DOI: 10.1016/j.bone.2013.01.025.BooksConceptsBone lossLevels of PTHrPNegative calcium balanceLevels of estrogenPrincipal bone-resorbing cellsSkeletal calcium storesBone-resorbing cellsPTHrP levelsBone turnoverBone resorptionBone massMineral metabolismCalcium balanceRole of osteocytesCalcium storesMineral homeostasisOsteocytic osteolysisReproductive cycleOsteocytesSystemic demandsPericanalicular matrixCalciumLactationBone
2011
Dietary Protein’s Impact on Skeletal Health
Surdykowski A, Kenney A, Insogna K, Kerstetter J. Dietary Protein’s Impact on Skeletal Health. 2011, 237-246. DOI: 10.1201/b11228-18.Peer-Reviewed Original ResearchInsulin-like growth factor-1Skeletal healthLoss of calciumUrinary calcium excretionIntestinal calcium absorptionNegative calcium balanceGrowth factor-1Skeletal storesCalcium excretionVitamin DDietary calciumMuscle strengthCalcium absorptionCalcium metabolismSystemic acidosisBone balanceCalcium balanceHigh intakeDietary proteinFactor 1HealthIntense investigationCalciumProtein impactMetabolism
2010
Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial
Wright MJ, Sullivan RR, Gaffney‐Stomberg E, Caseria DM, O'Brien KO, Proctor DD, Simpson CA, Kerstetter JE, Insogna KL. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial. Journal Of Bone And Mineral Research 2010, 25: 2205-2211. PMID: 20499372, PMCID: PMC3312746, DOI: 10.1002/jbmr.108.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionProton pump inhibitorsCalcium absorptionGastric acidDual-stable calcium isotopesYoung adultsChronic PPI therapyPotent gastric acidGastric acid suppressionNegative calcium balanceGastric acid productionHealthy young adultsPPI esomeprazolePPI therapyPlacebo groupUrinary calciumAcid suppressionCrossover studyBone lossPump inhibitorsClinical trialsIntervention periodAcute effectsCalcium balanceHealthy individuals
2009
Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat
Zerwekh JE, Zou L, Pak CY, Moe OW, Preisig PA. Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat. Bone 2009, 45: 1004-1009. PMID: 19651255, PMCID: PMC2753741, DOI: 10.1016/j.bone.2009.07.077.Peer-Reviewed Original ResearchConceptsHigh animal protein intakeAnimal protein intakeAlkali therapyBone histomorphometryBone turnoverProtein intakeAcid loadChronic acid loadMajor skeletal effectCancellous bone volumeHigh casein dietNegative calcium balanceDynamic bone histomorphometryLow urinary pHBone formation rateDietary animal protein intakeStatic bone histomorphometryNet acid excretionLow caseinSubstantial acid loadOsteoclastic surfaceWesternized dietUrinary pHUrine biochemistryBone resorption
2003
Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation
VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2003, 112: 1429-1436. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/jci19504.Peer-Reviewed Original ResearchConceptsBone lossBone turnoverMammary epithelial cellsParathyroid hormone-related proteinMammary glandMammary-specific deletionPTHrP-knockout miceRapid bone lossEpithelial cellsDihydroxy vitamin DNegative calcium balanceHormone-related proteinPreserves bone massAbsence of PTHrPExpression of CreUrinary cAMPVitamin DBone resorptionLate pregnancyBone massPTHrP mRNACalcium balanceKnockout micePTHrP proteinMammary development
1999
Changes in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein1
Kerstetter J, Mitnick M, Gundberg C, Caseria D, Ellison A, Carpenter T, Insogna K. Changes in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1052-1055. PMID: 10084594, DOI: 10.1210/jcem.84.3.5552.Peer-Reviewed Original ResearchUrinary N-telopeptide excretionBone-specific alkaline phosphataseN-telopeptide excretionUrinary calcium excretionBone turnoverLow-protein dietCalcium excretionUrinary calciumProtein dietBone resorptionDietary proteinYoung womenHealthy young womenNegative calcium balanceLow protein intakeHigh-protein dietAlkaline phosphataseSecondary hyperparathyroidismSerum PTHSerum osteocalcinDihydroxyvitamin DCalcium balanceProtein intakeCompensatory increaseDay 4
1997
Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet
Kerstetter J, Caseria D, Mitnick M, Ellison A, Gay L, Liskov T, Carpenter T, Insogna K. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. American Journal Of Clinical Nutrition 1997, 66: 1188-1196. PMID: 9356538, DOI: 10.1093/ajcn/66.5.1188.Peer-Reviewed Original ResearchConceptsLow-protein dietHigh-protein dietSerum PTHDietary proteinMedium protein dietCyclic adenosine monophosphateDay 4Nephrogenous cyclic adenosine monophosphateYoung womenIntestinal calcium absorptionNegative calcium balanceProtein-restricted dietSerum calcitriolUrinary calciumCalcitropic hormonesHealthy womenParathyroid hormoneBone turnSkeletal healthPTH bioactivityCalcium absorptionCalcium metabolismProtein restrictionRenal mechanismsMineral metabolism
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply