2009
Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat
Zerwekh JE, Zou L, Pak CY, Moe OW, Preisig PA. Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat. Bone 2009, 45: 1004-1009. PMID: 19651255, PMCID: PMC2753741, DOI: 10.1016/j.bone.2009.07.077.Peer-Reviewed Original ResearchConceptsHigh animal protein intakeAnimal protein intakeAlkali therapyBone histomorphometryBone turnoverProtein intakeAcid loadChronic acid loadMajor skeletal effectCancellous bone volumeHigh casein dietNegative calcium balanceDynamic bone histomorphometryLow urinary pHBone formation rateDietary animal protein intakeStatic bone histomorphometryNet acid excretionLow caseinSubstantial acid loadOsteoclastic surfaceWesternized dietUrinary pHUrine biochemistryBone resorption
2006
The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase
Kovacikova J, Winter C, Loffing-Cueni D, Loffing J, Finberg K, Lifton R, Hummler E, Rossier B, Wagner C. The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase. Kidney International 2006, 70: 1706-1716. PMID: 16985514, DOI: 10.1038/sj.ki.5001851.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAmilorideAnimalsDiureticsEpithelial Sodium ChannelsFurosemideGene Expression RegulationGene Expression Regulation, EnzymologicHydrochlorothiazideHydrogen-Ion ConcentrationKidney Tubules, CollectingKidney Tubules, DistalMetabolic Clearance RateMiceMice, KnockoutNephronsProton-Translocating ATPasesWater-Electrolyte BalanceConceptsUrinary acidificationRenal clearance experimentsEffect of furosemideNormal urinary acidificationLumen-negative voltageNet acid excretionThick ascending limbFinal urinary acidificationKidney-specific inactivationENaC channelsClearance experimentsAcid excretionMouse modelAscending limbFurosemideDuct cellsProton secretionMiceExact localizationReabsorptionMain siteB1 subunitAlpha subunitTubulesFunctional expressionMeat and Soy Protein Affect Calcium Homeostasis in Healthy Women 1 , 2
Kerstetter JE, Wall DE, O’Brien K, Caseria DM, Insogna KL. Meat and Soy Protein Affect Calcium Homeostasis in Healthy Women 1 , 2. Journal Of Nutrition 2006, 136: 1890-1895. PMID: 16772455, DOI: 10.1093/jn/136.7.1890.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionUrinary calciumCalcium absorptionLow-protein dietHealthy womenCalcium homeostasisHigher protein interventionNet acid excretionSubset of subjectsHigh-protein dietSoy interventionParathyroid hormoneExperimental periodSerum concentrationsAcid excretionSoy dietAcute declineWomen 1Calcium bioavailabilityRandom orderDietary proteinMeat dietDietSoy proteinIntervention
2003
Effect of high protein diet on stone-forming propensity and bone loss in rats
Amanzadeh J, Gitomer WL, Zerwekh JE, Preisig PA, Moe OW, Pak CY, Levi M. Effect of high protein diet on stone-forming propensity and bone loss in rats. Kidney International 2003, 64: 2142-2149. PMID: 14633136, DOI: 10.1046/j.1523-1755.2003.00309.x.Peer-Reviewed Original ResearchConceptsHigh casein dietHigh casein groupBone lossCasein groupCasein dietHigh-protein dietProtein dietPathogenesis of hypercalciuriaSerum calcitriol concentrationsStone-forming propensityUrinary calcium excretionBrush border membraneRisk of nephrolithiasisUrinary citrate excretionHigh protein intakeLow casein dietHigher urinary volumeResponse of kidneyNet acid excretionSubstantial acid loadKidney stone formationDays of studyCalcium excretionCalcitriol concentrationsCortical brush border membrane
1991
Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion*
SAKHAEE K, ALPERN R, JACOBSON H, PAK C. Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 396-400. PMID: 1899422, DOI: 10.1210/jcem-72-2-396.Peer-Reviewed Original ResearchConceptsCitrate clearanceAcid-base statusUrinary citratePotassium citrateRenal citrate excretionMeq/dayPotassium citrate treatmentWeeks of treatmentNet acid excretionCitraturic responseUrinary ammoniumOral administrationCitrate excretionAcid excretionPotassium chlorideUrinary bicarbonateCitrate treatmentAlkali loadPotassium bicarbonateClearanceML/minExcretionDaysTreatmentTitratable acid
1970
Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat
Luke R, Warren Y, Kashgarian M, Levitin H. Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat. Clinical Science 1970, 38: 385-396. PMID: 5442558, DOI: 10.1042/cs0380385.Peer-Reviewed Original ResearchConceptsUrinary net acid excretionNet acid excretionAcid excretionPlasma bicarbonateProximal tubulesBicarbonate absorptionDietary chloride restrictionProximal tubular absorptionUrinary acid excretionEndogenous acid productionLow chloride dietDegree of elevationAcid-base balanceDietary sodiumPlasma chlorideSerum bicarbonateTubular absorptionPhosphate excretionRespiratory acidosisMicropuncture experimentsDepleted ratsHypochloraemiaRatsExcretionRates of sodium
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply