2017
Natural Killer T Cells in Cancer Immunotherapy
Nair S, Dhodapkar MV. Natural Killer T Cells in Cancer Immunotherapy. Frontiers In Immunology 2017, 8: 1178. PMID: 29018445, PMCID: PMC5614937, DOI: 10.3389/fimmu.2017.01178.Peer-Reviewed Original Research
2015
The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies
Dosani T, Carlsten M, Maric I, Landgren O. The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies. Blood Cancer Journal 2015, 5: e306-e306. PMID: 25885426, PMCID: PMC4450330, DOI: 10.1038/bcj.2015.32.Peer-Reviewed Original ResearchConceptsDevelopment of MMMultiple myelomaT cellsImmune systemNatural killer T cellsRegulatory T cellsKiller T cellsNatural killer cellsConventional T cellsΓδ T cellsCellular immune systemImmune subsetsNK cellsKiller cellsPeripheral bloodUndetermined significanceImmune cellsMonoclonal gammopathyImmune componentsTumor evolutionBone marrowMyelomagenesisImmunotherapyPrecursor conditionsCurrent literature
2014
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Nair S, Boddupalli CS, Verma R, Liu J, Yang R, Pastores GM, Mistry PK, Dhodapkar MV. Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation. Blood 2014, 125: 1256-1271. PMID: 25499455, PMCID: PMC4335081, DOI: 10.1182/blood-2014-09-600270.Peer-Reviewed Original ResearchConceptsI NKT cellsNKT cellsB cell activationT cellsB cellsTetramer-positive T cellsType II natural killer T cellsT cell receptor usageType I NKT cellsType II NKT cellsNatural killer T cellsFollicular helper phenotypeGD mouse modelMetabolic lipid disordersKiller T cellsB cell immunityGerminal center B cellsB-cell malignanciesAntilipid antibodiesDisease activityCytokine profileChronic inflammationHelper phenotypeHumoral immunityCognate helpType II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation
Nair S, Boddupalli C, Verma R, Liu J, Ruhua Y, Pastores G, Mistry P, Dhodapkar M. Type II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation. Blood 2014, 124: 755. DOI: 10.1182/blood.v124.21.755.755.Peer-Reviewed Original ResearchType II NKT cellsType I NKT cellsLipid-specific T cellsI NKT cellsNKT cellsB cell immunityT cellsTFH markersAnti-lipid antibodiesΑ-GalCerGaucher diseaseB cellsCD1d tetramersTFH phenotypeCell immunityHuman PBMCsGD miceMHC-like molecule CD1dNatural killer T cellsWild-type control miceCD1d-dependent mannerDiverse NKT cellsExpansion of plasmablastsFollicular helper phenotypeAutologous B cells
2013
PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD
Ghosh A, Holland A, Dogan Y, Yim N, Rao U, Young L, West M, Singer N, Lee H, Na I, Tsai J, Jenq R, Penack O, Hanash A, Lezcano C, Murphy G, Liu C, Sadelain M, Sauer M, Sant'Angelo D, van den Brink M. PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD. Cancer Research 2013, 73: 4687-4696. PMID: 23733752, PMCID: PMC3732814, DOI: 10.1158/0008-5472.can-12-4699.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsBone Marrow TransplantationFlow CytometryGraft vs Host DiseaseGraft vs Tumor EffectKruppel-Like Transcription FactorsLymphocyte ActivationLymphocyte Culture Test, MixedMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasms, ExperimentalPromyelocytic Leukemia Zinc Finger ProteinT-LymphocytesTransplantation, HomologousConceptsDonor T cellsT cellsPromyelocytic leukemia zinc fingerGVT effectInvariant natural killer T (iNKT) cellsAlloreactive donor T cellsAllogeneic bone marrow transplantationNatural killer T cellsTranscription factor promyelocytic leukemia zinc fingerKiller T cellsAlloreactive T cellsBone marrow transplantationConventional T cellsOverall improved outcomesLess GVHDLower GVHDPreserves graftTumor effectImproved survivalMarrow transplantationCytokine responsesImproved outcomesTumor relapseEffector functionsGVHD
2012
Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Richter J, Neparidze N, Zhang L, Nair S, Monesmith T, Sundaram R, Miesowicz F, Dhodapkar KM, Dhodapkar MV. Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma. Blood 2012, 121: 423-430. PMID: 23100308, PMCID: PMC3548165, DOI: 10.1182/blood-2012-06-435503.Peer-Reviewed Original ResearchConceptsHuman iNKT cellsINKT cellsCombination therapyAntitumor T-cell immunitySerum soluble IL2 receptorMonocyte-derived dendritic cellsNatural killer T cellsBroad immune activationLow-dose lenalidomideSoluble IL2 receptorCycles of therapyHuman NKT cellsT cell immunityKiller T cellsInnate immune cellsInduction of eosinophiliaActivation of monocytesPrevention of cancerCycles of combinationAsymptomatic myelomaClinical myelomaMeasurable diseaseClinical regressionClinical responseNKT cellsGlycolipid Antigens for Treating Hepatic Colorectal Cancer Metastases and Their Effect on the Therapeutic Efficacy of Live Attenuated Listeria monocytogenes
Olino K, Edil BH, Meckel KF, Pan X, Thuluvath A, Pardoll DM, Schulick RD, Yoshimura K, Weber WP. Glycolipid Antigens for Treating Hepatic Colorectal Cancer Metastases and Their Effect on the Therapeutic Efficacy of Live Attenuated Listeria monocytogenes. JAMA Surgery 2012, 147: 480-482. PMID: 22785644, PMCID: PMC4144826, DOI: 10.1001/archsurg.2011.2206.Peer-Reviewed Original ResearchConceptsNatural killer T cellsHepatic colorectal cancer metastasesKiller T cellsColorectal cancer metastasisT cellsNatural Killer T Cell SubsetsCancer metastasisAntitumor activityT cell subsetsAttenuated Listeria monocytogenesPotential of glycolipidsTumor challengeHepatic metastasesMultiple administrationsGlycolipid antigensTherapeutic efficacyListeria monocytogenesActin AAntitumor efficacyMetastasisFurther investigationAdministrationEfficacySpecific glycolipidsSurvival
2011
Understanding the Role of Natural Killer T Cells in Hematologic Malignancies: Progress and Challenges
Neparidze N, Dhodapkar M. Understanding the Role of Natural Killer T Cells in Hematologic Malignancies: Progress and Challenges. Cancer Drug Discovery And Development 2011, 153-167. DOI: 10.1007/978-1-4614-0613-6_9.Peer-Reviewed Original ResearchNatural killer T cellsKiller T cellsNKT cellsHematologic malignanciesT cellsImportant effector cellsPreliminary clinical studyAnti-tumor effectsNKT functionDendritic cellsTumor immunityEffector cellsHematologic tumorsClinical studiesMalignancyQualitative defectsPatientsCD1dType IAttractive targetCellsVivoClinicNKTTumorsStimulatory Lipids Accumulate in the Mouse Liver within 30 min of Contact Sensitization to Facilitate the Activation of Naïve iNKT Cells in a CD1d‐Dependent Fashion
Dey N, Szczepanik M, Lau K, Majewska‐Szczepanik M, Askenase PW. Stimulatory Lipids Accumulate in the Mouse Liver within 30 min of Contact Sensitization to Facilitate the Activation of Naïve iNKT Cells in a CD1d‐Dependent Fashion. Scandinavian Journal Of Immunology 2011, 74: 52-61. PMID: 21352253, DOI: 10.1111/j.1365-3083.2011.02540.x.Peer-Reviewed Original ResearchConceptsHepatic iNKT cellsINKT cellsContact sensitivityHepatic lipidsT cellsB cellsNatural killer T cellsAdoptive transfer techniquesEffector T cellsLiver mononuclear cellsCutaneous inflammatory responseINKT cell activationKiller T cellsMouse liverΑβ T cell receptorAllergic contact dermatitisInnate immune systemRecipient mouse liversSame allergenContact hypersensitivityTopical sensitizationContact sensitizationIgM antibodiesMononuclear cellsIL-4
2010
Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases
Rohr J, Beutel K, Maul-Pavicic A, Vraetz T, Thiel J, Warnatz K, Bondzio I, Gross-Wieltsch U, Schündeln M, Schütz B, Woessmann W, Groll A, Strahm B, Pagel J, Speckmann C, Janka G, Griffiths G, Schwarz K, zur Stadt U, Ehl S. Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases. Haematologica 2010, 95: 2080-2087. PMID: 20823128, PMCID: PMC2995566, DOI: 10.3324/haematol.2010.029389.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesB-LymphocytesCD8-Positive T-LymphocytesCell DegranulationCell Line, TumorCells, CulturedChildChild, PreschoolCytotoxicity, ImmunologicFlow CytometryGene FrequencyHumansImmunoglobulin GImmunologic Deficiency SyndromesK562 CellsKiller Cells, NaturalLymphohistiocytosis, HemophagocyticMembrane ProteinsMunc18 ProteinsMutationRNA Splice SitesConceptsFamilial hemophagocytic lymphohistiocytosisNatural killer T cellsPrimary immunodeficiency diseasesHemophagocytic lymphohistiocytosisKiller T cellsT cellsNK cellsImmunodeficiency diseaseB cellsChronic active Epstein-Barr virus infectionActive Epstein-Barr virus infectionMarkers of T-cell activationActivated CD8(+) T cellsEpisodes of hemophagocytic lymphohistiocytosisReduced memory B cellsCD8(+) T cellsHematopoietic stem cell transplantationEpstein-Barr virus infectionIncreased susceptibility to bacterial infectionsT cell cytotoxicityStem cell transplantationNK cell degranulationAssociated with immunodeficiencyNK cell cytotoxicityMemory B cells
2009
Harnessing CD1d‐Restricted T Cells toward Antitumor Immunity in Humans
Neparidze N, Dhodapkar MV. Harnessing CD1d‐Restricted T Cells toward Antitumor Immunity in Humans. Annals Of The New York Academy Of Sciences 2009, 1174: 61-67. PMID: 19769737, PMCID: PMC2782771, DOI: 10.1111/j.1749-6632.2009.04931.x.Peer-Reviewed Original ResearchConceptsNKT cellsT cellsAntitumor immunityType I NKT cellsType II NKT cellsNatural killer T cellsPresence of CD1dI NKT cellsKiller T cellsAdvanced myelomaNKT activationDendritic cellsImmune therapyAlpha-GalactosylceramideCancer patientsCD1d moleculesLipid antigensPreclinical studiesThalidomide analoguesCD1dDistinct subsetsAgonist ligandsPatientsCancerType IHuman innate immunosenescence: causes and consequences for immunity in old age
Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends In Immunology 2009, 30: 325-333. PMID: 19541535, PMCID: PMC4067971, DOI: 10.1016/j.it.2009.05.004.Peer-Reviewed Original ResearchConceptsInnate immune system initiatesNatural killer T cellsOlder ageAntiviral cytokine productionKiller T cellsInnate immune responseInnate immune systemDendritic cellsNatural killerCytokine productionHuman immunosenescenceT cellsImmune responseAdaptive immunityImmune systemInnate immunityImmunityAgeCellsDiverse cellsImmunosenescenceVaccinationNeutrophilsMonocytesInfection
2008
Conventional and Unconventional T Cells
Roberts S, Girardi M. Conventional and Unconventional T Cells. 2008, 85-104. DOI: 10.1007/978-1-84800-165-7_6.Peer-Reviewed Original ResearchUnconventional T cellsConventional T cellsT cellsT cell receptorInvariant natural killer T (iNKT) cellsNatural killer T cellsContext of CD1dKiller T cellsNatural killer cellsNKT cellsLymph nodesKiller cellsPeripheral bloodGenitourinary tractInflammatory responseT lymphocytesGastrointestinal tractFunctional capacityCo-receptors CD4Host defenseCell receptorCancer cellsEpithelial environmentLymphocytesInfection
2007
c-Jun NH2-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection
Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection. Infection And Immunity 2007, 76: 308-316. PMID: 17998313, PMCID: PMC2223674, DOI: 10.1128/iai.00599-07.Peer-Reviewed Original ResearchConceptsIFN-gamma productionA. phagocytophilum infectionPhagocytophilum infectionIFN-gammaJnk2-null miceNatural killer T cellsA. phagocytophilumKiller T cellsIFN-gamma releaseIFN-gamma secretionGamma interferon productionT cell agonistsAnaplasma phagocytophilum infectionT cellsEarly eradicationGamma interferonInterferon productionInfectionC-Jun NH2-terminal kinase-2Inhibitory effectElevated levelsMiceAnaplasma phagocytophilumPhagocytophilumKinase 2
2003
Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones
Remenyik É, Wikonkál NM, Zhang W, Paliwal V, Brash DE. Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones. Oncogene 2003, 22: 6369-6376. PMID: 14508517, DOI: 10.1038/sj.onc.1206657.Peer-Reviewed Original ResearchConceptsAntigen-specific immunityP53-mutant clonesUltraviolet BAcute regressionNatural killer T cellsKiller T cellsRag1 knockout miceChronic UVB irradiationMurine skin tumorsInduction of carcinomasSignificant differencesUVB carcinogenesisT cellsSkin tumorsKnockout micePersistence of clonesEpidermal thicknessMurine epidermisUVB irradiationEpidermal sheetsImmunityChronic irradiationGene 1MiceRegression
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