2021
Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells
Choi W, Ryu T, Lee J, Shim Y, Kim M, Kim H, Kim Y, Yang K, Kim K, Choi S, Kim W, Kim S, Eun H, Jeong W. Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 2021, 74: 2170-2185. PMID: 33932306, DOI: 10.1002/hep.31875.Peer-Reviewed Original ResearchConceptsNK cell cytotoxicityProduction of IFN-gMGluR5 knockout miceMetabotropic glutamate receptor 5Activation of mGluR5NK cellsGlutamate receptor 5Liver fibrosisIFN-gCell cytotoxicityIn vitro activityNatural killerMGluR5 activationKnockout miceReceptor 5Frequency of NK cellsCytotoxicity of NK cellsReduced stimulationAdvanced liver fibrosisNatural killer cellsStimulation of mGluR5Wild-type miceLiver fibrosis regressionActivated stellate cellsInjection of carbon tetrachloride
2018
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse
Lee J, Dieckmann N, Edgar J, Griffiths G, Siegel R. Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse. Immunity Inflammation And Disease 2018, 6: 312-321. PMID: 29642281, PMCID: PMC5946154, DOI: 10.1002/iid3.219.Peer-Reviewed Original ResearchConceptsIntraluminal vesiclesImmune synapseCytolytic granulesImmune synapsesCognate receptor FasType II transmembrane proteinFormation of immune synapsesMembrane-bound FasLNK cellsPerforin-containing granulesIntra-luminal vesiclesReceptor FasFusion proteinTransmembrane proteinsB cellsPlasma membraneFas ligandFasLImmunoelectron microscopyNK cell cytotoxicityHuman NK cellsFASDense-coreVesiclesPerforin/granzyme system
2010
Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases
Rohr J, Beutel K, Maul-Pavicic A, Vraetz T, Thiel J, Warnatz K, Bondzio I, Gross-Wieltsch U, Schündeln M, Schütz B, Woessmann W, Groll A, Strahm B, Pagel J, Speckmann C, Janka G, Griffiths G, Schwarz K, zur Stadt U, Ehl S. Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases. Haematologica 2010, 95: 2080-2087. PMID: 20823128, PMCID: PMC2995566, DOI: 10.3324/haematol.2010.029389.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesB-LymphocytesCD8-Positive T-LymphocytesCell DegranulationCell Line, TumorCells, CulturedChildChild, PreschoolCytotoxicity, ImmunologicFlow CytometryGene FrequencyHumansImmunoglobulin GImmunologic Deficiency SyndromesK562 CellsKiller Cells, NaturalLymphohistiocytosis, HemophagocyticMembrane ProteinsMunc18 ProteinsMutationRNA Splice SitesConceptsFamilial hemophagocytic lymphohistiocytosisNatural killer T cellsPrimary immunodeficiency diseasesHemophagocytic lymphohistiocytosisKiller T cellsT cellsNK cellsImmunodeficiency diseaseB cellsChronic active Epstein-Barr virus infectionActive Epstein-Barr virus infectionMarkers of T-cell activationActivated CD8(+) T cellsEpisodes of hemophagocytic lymphohistiocytosisReduced memory B cellsCD8(+) T cellsHematopoietic stem cell transplantationEpstein-Barr virus infectionIncreased susceptibility to bacterial infectionsT cell cytotoxicityStem cell transplantationNK cell degranulationAssociated with immunodeficiencyNK cell cytotoxicityMemory B cells
2002
Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10
Santin AD, Bellone S, Palmieri M, Bossini B, Dunn D, Roman JJ, Pecorelli S, Cannon M, Parham GP. Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10. International Journal Of Radiation Oncology • Biology • Physics 2002, 54: 1345-1355. PMID: 12459356, DOI: 10.1016/s0360-3016(02)03757-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntigens, CD19Blood TransfusionB-LymphocytesCD3 ComplexCD4-Positive T-LymphocytesCD56 AntigenCD8-Positive T-LymphocytesCytokinesFemaleFlow CytometryHumansImmunophenotypingInterleukin-10Killer Cells, NaturalLymphocyte SubsetsMembrane GlycoproteinsMiddle AgedPerforinPore Forming Cytotoxic ProteinsRadiotherapyReceptors, IgGReceptors, Interleukin-2Time FactorsUterine Cervical NeoplasmsConceptsBlood transfusionT cellsUntransfused groupIL-10Transfused groupNK cellsUntransfused patientsCervical cancerIL-2Immune functionB cellsElevated serum IL-10NK-sensitive target KCD4/CD8 ratioImmunoregulatory cytokine IL-10Depression of NKIncrease of CD8Perforin-positive CD8Radiation-induced immunosuppressionPercentage of CD4Serum IL-10HLA-DR expressionNK cell cytotoxicityNumber of CD8Advanced cervical cancer
1987
Role of CD8+ and CD8- Cytolytic Effectors in IL2 Reversal of Cyclosporin-Inhibited EBV-B-Cell Cytotoxicity
Hudnall S, Kurbe M. Role of CD8+ and CD8- Cytolytic Effectors in IL2 Reversal of Cyclosporin-Inhibited EBV-B-Cell Cytotoxicity. Experimental Biology And Medicine 1987, 513-515. DOI: 10.1007/978-1-4612-4590-2_110.Peer-Reviewed Original ResearchEpstein-Barr virusPeripheral blood mononuclear cellsRecombinant interleukin-2Interleukin-2B cellsAutologous Epstein-Barr virusB95-8 Epstein-Barr virusRole of CD8NK cell cytotoxicityOrgan transplant recipientsBlood mononuclear cellsForm of cytotoxicityReactivation infectionTransplant recipientsSuppressor/Effector phenotypeMalignant lymphomaCytolytic effectorsMononuclear cellsT cellsCell cytotoxicityCyclosporin ADrug cyclosporin ACsACytotoxicity
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