2024
A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation
Wang H, Slotabec L, Didik S, Li Z, Leng L, Zhao B, Bucala R, Li J. A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation. Metabolism 2024, 153: 155792. PMID: 38232801, PMCID: PMC10932879, DOI: 10.1016/j.metabol.2024.155792.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorActivating AMP-activated protein kinaseI/R stressAging heartMacrophage migration inhibitory factor expressionCardiac metabolic profileReactive oxygen speciesIschemia-reperfusion insultIschemia-reperfusion (I/RAMP-activated protein kinaseMIF signalingMigration inhibitory factorDecreased myocardial infarct sizeAccumulation of reactive oxygen speciesMyocardial infarct sizeSystolic functionInnate cytokinesPharmacological augmentationSenescent heartsAged myocardiumSenescent myocardiumAge-related reductionIschemia-reperfusionI/R injuryMetabolic profile
2018
Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation
Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, Liu Z, Du J, Wang L, Yin C, Liao Y, Shang H, Martin KA, Herzog RI, Young LH, Qian L, Hwa J, Xiang Y. Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic To Translational Science 2018, 3: 350-362. PMID: 30062222, PMCID: PMC6058960, DOI: 10.1016/j.jacbts.2018.01.005.Peer-Reviewed Original ResearchR injuryInfarct sizeMyocardial ischemia/reperfusion injuryIschemia/reperfusion injuryMyocardial ischemia/reperfusionMiR-24Ischemia/reperfusionMyocardial infarct sizePromising therapeutic candidateReperfusion injuryDiabetic heartMyocardial infarctionPoor survivalMouse modelTherapeutic candidateO-GlcNAcylationGenetic overexpressionUp-RegulationInjuryDown regulationMultiple key proteinsKey proteinsHeartReperfusionHyperglycemia
2017
What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
Kuijt WJ, Green CL, Verouden NJW, Haeck JDE, Tzivoni D, Koch KT, Stone GW, Lansky AJ, Broderick S, Tijssen JGP, de Winter RJ, Roe MT, Krucoff MW. What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Journal Of Electrocardiology 2017, 50: 952-959. PMID: 29153151, DOI: 10.1016/j.jelectrocard.2017.04.009.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionST-segment recoveryPrimary percutaneous coronary interventionPercutaneous coronary interventionElevation myocardial infarctionInfarct sizeCoronary interventionMyocardial infarctionHolter ECG monitoringMyocardial infarct sizeSingle photon emissionMultivariable adjustmentClinical outcomesRisk factorsClinical trialsNoninvasive biomarkersCore laboratoryMechanistic correlatesMortalityECG monitoringInfarctionRecovery parametersST parametersInterventionOutcomes
2015
Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart
Jamwal S, Kumar K, Reddy BV. Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart. Perfusion 2015, 31: 334-342. PMID: 26423303, DOI: 10.1177/0267659115608935.Peer-Reviewed Original ResearchConceptsDiabetic rat heartsMyocardial infarct sizeCreatine kinase-MBZinc ionophore pyrithioneIschemic preconditioningNormal rat heartsCardioprotective potentialInfarct sizeRat heartMPO levelsDiabetes mellitusCoronary effluentLactate dehydrogenaseSTZ-induced diabetic rat heartIonophore pyrithioneGSK-3βPost-ischemic treatmentMinutes of reperfusionRelease of LDHMinutes of ischemiaTriphenyltetrazolium chloride stainingGSK-3β levelsSingle intraperitoneal administrationGlycogen synthase kinase-3βNeutrophil accumulation
2007
Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling.
Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswami SK, Ghatpande S, Engelman RM, Simons M, Das DK. Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling. Antioxidants And Redox Signaling 2007, 9: 437-45. PMID: 17280485, DOI: 10.1089/ars.2006.1501.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsAntimicrobial Cationic PeptidesApoptosisBlotting, WesternCell LineGenetic TherapyHumansHypoxia-Inducible Factor 1, alpha SubunitIn Situ Nick-End LabelingMaleMalondialdehydeMiceMice, Inbred C57BLMutationMyocardial Reperfusion InjuryReactive Oxygen SpeciesReceptor, Fibroblast Growth Factor, Type 1Signal TransductionTime FactorsConceptsCoronary flowMyocardial ischemic reperfusion injuryMyocardial ischemia-reperfusion injuryEmpty vectorIschemia-reperfusion injuryIschemic reperfusion injuryLVdP/dtVentricular developed pressureMin of ischemiaBaseline coronary flowMyocardial infarct sizeGene therapyReperfusion injuryCardioprotective abilityInfarct sizeDeveloped pressureHIF-1alpha proteinTTC stainingAortic flowHeart rateCardiomyocyte apoptosisEx vivoCardioprotectionHIF1alpha stabilizationHemodynamics
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