2025
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex
Vargas-Ortiz J, Lin L, Martinez V, Liu R, Babij R, Duan Z, Wacks S, Sun L, Wang A, Khan S, Soto-Vargas J, De Marco García N, Che A. Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex. Nature Communications 2025, 16: 1296. PMID: 39900899, PMCID: PMC11791040, DOI: 10.1038/s41467-024-55783-w.Peer-Reviewed Original ResearchThis study shows how connections across layers in the cortex synchronize early brain activity, guiding sensory development and informing strategies to address neurodevelopmental disorders.
2015
Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex
Che A, Truong DT, Fitch RH, LoTurco JJ. Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cerebral Cortex 2015, 26: 3705-3718. PMID: 26250775, PMCID: PMC5004750, DOI: 10.1093/cercor/bhv168.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistFunctional synaptic circuitryEvoked glutamate releaseGlutamatergic synaptic transmissionLayer 4 neuronsExcitatory transmissionGlutamate releaseThalamocortical connectionsAmbient glutamateMK-801Receptor antagonistAcute applicationProbability of releaseSomatosensory cortexSynaptic circuitryNMDAR activationSynaptic transmissionSynaptic releaseExcitatory connectivityPostsynaptic NMDARsCortical connectivitySomatosensory neocortexMouse neocortexNMDARNeocortex
2014
Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex
Fertuzinhos S, Li M, Kawasawa YI, Ivic V, Franjic D, Singh D, Crair M, Šestan N. Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex. Cell Reports 2014, 6: 938-950. PMID: 24561256, PMCID: PMC3999901, DOI: 10.1016/j.celrep.2014.01.036.Peer-Reviewed Original ResearchConceptsTemporal expression dynamicsExpression dynamicsDistinct biological processesGene coexpression networksSpecific spatiotemporal expressionSmall RNAsNoncoding RNAsTranscriptional differencesTranscriptional eventsSplicing patternsCoexpression networkMRNA interactionsPotential miRNATranscriptional overlapDeep sequencingBiological processesSpatiotemporal expressionMouse neocortexCell typesTranscriptsStudies of neurodevelopmentIntegrated viewTemporal dynamicsCharacteristic setTranscriptome
2013
The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex
Che A, Girgenti MJ, LoTurco J. The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex. Biological Psychiatry 2013, 76: 387-396. PMID: 24094509, PMCID: PMC4025976, DOI: 10.1016/j.biopsych.2013.08.018.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsDyslexiaExcitatory Amino Acid AntagonistsGene ExpressionMembrane PotentialsMiceMice, KnockoutMicroelectrodesMicrotubule-Associated ProteinsNeocortexPatch-Clamp TechniquesPhenolsPiperidinesPyramidal CellsReceptors, N-Methyl-D-AspartateReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNATissue Culture TechniquesConceptsAmino-5-phosphonovaleric acidWhole-cell patch-clamp recordingsActivity of NMDARsAction potential firingWild-type micePatch-clamp recordingsTranscriptase-polymerase chain reactionSpike-timing precisionPyramidal neuronsElectrophysiological assessmentNMDAR antagonistsPolymerase chain reactionRo 25Neocortical activationClamp recordingsNeuronal physiologyElectrophysiological propertiesMouse neocortexRibonucleic acid sequencingFunctional increaseTemporal precisionChain reactionSequencing screenGene expressionNeocortex
2006
Non-synaptic dendritic spines in neocortex
Arellano J, Espinosa A, Fairén A, Yuste R, DeFelipe J. Non-synaptic dendritic spines in neocortex. Neuroscience 2006, 145: 464-469. PMID: 17240073, DOI: 10.1016/j.neuroscience.2006.12.015.Peer-Reviewed Original Research
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