2015
Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex
Che A, Truong DT, Fitch RH, LoTurco JJ. Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cerebral Cortex 2015, 26: 3705-3718. PMID: 26250775, PMCID: PMC5004750, DOI: 10.1093/cercor/bhv168.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistFunctional synaptic circuitryEvoked glutamate releaseGlutamatergic synaptic transmissionLayer 4 neuronsExcitatory transmissionGlutamate releaseThalamocortical connectionsAmbient glutamateMK-801Receptor antagonistAcute applicationProbability of releaseSomatosensory cortexSynaptic circuitryNMDAR activationSynaptic transmissionSynaptic releaseExcitatory connectivityPostsynaptic NMDARsCortical connectivitySomatosensory neocortexMouse neocortexNMDARNeocortexTet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair
Yu H, Su Y, Shin J, Zhong C, Guo J, Weng Y, Gao F, Geschwind D, Coppola G, Ming G, Song H. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience 2015, 18: 836-843. PMID: 25915473, PMCID: PMC4446239, DOI: 10.1038/nn.4008.Peer-Reviewed Original Research
2013
Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability
Brockie PJ, Jensen M, Mellem JE, Jensen E, Yamasaki T, Wang R, Maxfield D, Thacker C, Hoerndli F, Dunn PJ, Tomita S, Madsen DM, Maricq AV. Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability. Neuron 2013, 80: 129-142. PMID: 24094107, PMCID: PMC3795439, DOI: 10.1016/j.neuron.2013.07.028.Peer-Reviewed Original ResearchConceptsGlutamatergic synaptic transmissionGlutamate-gated currentsNervous system functionIonotropic glutamate receptorsC. elegansER exportSynaptic excitabilityCargo adaptorsTransgenic wormsGenetic approachesOpposite phenotypeCornichon ProteinsGlutamate receptorsSynaptic transmissionAgonist AMPAHeterologous cellsAMPA receptorsCentral synapsesAMPAR numberSynaptic communicationReconstitution studiesLaminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factorsErratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad T, Gan G, Gao X, Taylor H. Erratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2013, 3: 1320. PMCID: PMC3575011, DOI: 10.1038/srep01320.Peer-Reviewed Original ResearchMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
2012
Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad TS, Gan G, Gao XB, Taylor HS. Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2012, 2: 312. PMID: 22428084, PMCID: PMC3306017, DOI: 10.1038/srep00312.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
2011
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nature Reviews Neuroscience 2011, 13: 22-37. PMID: 22127301, PMCID: PMC3645314, DOI: 10.1038/nrn3138.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate transmissionAcute stressCognitive functionPrefrontal cortexPrefrontal cortex-dependent cognitive functionsGlutamatergic synaptic transmissionLimbic brain areasGlutamatergic neurotransmitter systemChronic stress exposureUnmet therapeutic needMonoaminergic mechanismsNeurochemical mediatorsCertain cognitive functionsLimbic regionsPrimary neurotransmitterNMDA receptorsGlutamate receptorsNeurotransmitter systemsPharmacological interventionsSynaptic transmissionGlutamate synapseMaladaptive changesBrain areasBrain tissue
2010
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts B, Holden D, Shaffer C, Seymour P, Menniti F, Schmidt C, Williams G, Castner S. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behavioural Brain Research 2010, 212: 41-48. PMID: 20347881, DOI: 10.1016/j.bbr.2010.03.039.Peer-Reviewed Original ResearchMeSH Keywordsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnalysis of VarianceAnimalsAnimals, NewbornArea Under CurveDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleExcitatory Amino Acid AgonistsKetamineMacaca fascicularisMacaca mulattaMemory DisordersMemory, Short-TermMotor ActivityNeuropsychological TestsReaction TimeSulfonamidesThiophenesTime FactorsConceptsCognitive impairment associated with schizophreniaAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidMemory impairmentN-methyl-D-aspartateCognitive dysfunctionCore aspect of schizophreniaEffects of acute ketamineBehavioral effects of ketaminePositive modulators of AMPA receptorsEffects of positive allosteric modulatorsModel of cognitive dysfunctionAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptorsNegative-like symptomsWorking Memory DeficitsWorking memory impairmentModulation of AMPA receptorsEffects of ketaminePositive allosteric modulatorsRegulation of NMDA receptorsGlutamatergic synaptic transmissionAcute ketamineWorking memoryPF-4778574Antagonist ketamineMemory deficits
2002
SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly
Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, Südhof T. SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly. Science 2002, 297: 1525-1531. PMID: 12202822, DOI: 10.1126/science.1072356.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBrainBrain ChemistryCell Adhesion MoleculesCell Adhesion Molecules, NeuronalCell LineCoculture TechniquesExocytosisHumansImmunoglobulinsMolecular Sequence DataNeuronsProsencephalonProtein Structure, TertiaryRatsReceptors, AMPARecombinant Fusion ProteinsSequence Homology, Amino AcidSynapsesSynaptic TransmissionTransfectionTumor Suppressor ProteinsConceptsSynapse assemblyHomophilic cell adhesion moleculeDomain-containing proteinsPDZ domain proteinsNonneuronal cellsAdhesion moleculesSynaptic adhesion moleculesImmunoglobulin domain-containing proteinsGlutamate receptorsCoordinated assemblyCytoplasmic tailCell adhesion moleculeGlutamatergic synaptic transmissionSynapse formationPostsynaptic specializationsPostsynaptic responsesHippocampal neuronsSynaptic transmissionProteinNerve cellsAssemblyCellsExpressionTight attachmentNeurons
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