2012
Mechanism of the Rhodium(III)-Catalyzed Arylation of Imines via C–H Bond Functionalization: Inhibition by Substrate
Tauchert ME, Incarvito CD, Rheingold AL, Bergman RG, Ellman JA. Mechanism of the Rhodium(III)-Catalyzed Arylation of Imines via C–H Bond Functionalization: Inhibition by Substrate. Journal Of The American Chemical Society 2012, 134: 1482-1485. PMID: 22257031, PMCID: PMC3269099, DOI: 10.1021/ja211110h.Peer-Reviewed Original ResearchConceptsCatalyzed ArylationH bond functionalizationC bond formationInverse first orderDetailed mechanistic studiesBond functionalizationStoichiometric reactionBond formationNew reactionFunctional groupsMechanistic studiesIminesArylationReactionFirst orderRelevant substratesSubstrateFunctionalizationCatalystAminesReactivityComplexes
2009
Application of Daugulis Copper-Catalyzed Direct Arylation to the Synthesis of 5-Aryl Benzotriazepines
Yotphan S, Bergman RG, Ellman JA. Application of Daugulis Copper-Catalyzed Direct Arylation to the Synthesis of 5-Aryl Benzotriazepines. Organic Letters 2009, 11: 1511-1514. PMID: 19260648, PMCID: PMC2674648, DOI: 10.1021/ol900103a.Peer-Reviewed Original Research
2008
Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines
Berman AM, Lewis JC, Bergman RG, Ellman JA. Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines. Journal Of The American Chemical Society 2008, 130: 14926-14927. PMID: 18855360, PMCID: PMC2647742, DOI: 10.1021/ja8059396.Peer-Reviewed Original ResearchRh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight
Lewis JC, Berman AM, Bergman RG, Ellman JA. Rh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight. Journal Of The American Chemical Society 2008, 130: 2493-2500. PMID: 18251465, PMCID: PMC2693036, DOI: 10.1021/ja0748985.Peer-Reviewed Original ResearchConceptsDirect arylationAryl bromide coupling partnerExcellent product yieldsLow molecular weight ligandsFunctional group tolerant methodPurification of reagentsMolecular weight ligandsTetrafluoroborate saltsBond activationProduct isolationAmide solventsAryl bromidesCoupling partnersWeight ligandsMicrowave reactorArylationCatalyzed ArylationHeterocyclesProduct yieldSolventReactionMechanistic insightsRhAzolesCatalyst
2006
Microwave‐Promoted Rhodium‐Catalyzed Arylation of Heterocycles through CH Bond Activation
Lewis JC, Wu JY, Bergman RG, Ellman JA. Microwave‐Promoted Rhodium‐Catalyzed Arylation of Heterocycles through CH Bond Activation. Angewandte Chemie International Edition 2006, 45: 1589-1591. PMID: 16444794, DOI: 10.1002/anie.200504289.Peer-Reviewed Original Research
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