2012
Mechanism of the Rhodium(III)-Catalyzed Arylation of Imines via C–H Bond Functionalization: Inhibition by Substrate
Tauchert ME, Incarvito CD, Rheingold AL, Bergman RG, Ellman JA. Mechanism of the Rhodium(III)-Catalyzed Arylation of Imines via C–H Bond Functionalization: Inhibition by Substrate. Journal Of The American Chemical Society 2012, 134: 1482-1485. PMID: 22257031, PMCID: PMC3269099, DOI: 10.1021/ja211110h.Peer-Reviewed Original ResearchConceptsCatalyzed ArylationH bond functionalizationC bond formationInverse first orderDetailed mechanistic studiesBond functionalizationStoichiometric reactionBond formationNew reactionFunctional groupsMechanistic studiesIminesArylationReactionFirst orderRelevant substratesSubstrateFunctionalizationCatalystAminesReactivityComplexes
2001
Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II*
Harris J, Niles A, Burdick K, Maffitt M, Backes B, Ellman J, Kuntz I, Haak-Frendscho M, Craik C. Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II*. Journal Of Biological Chemistry 2001, 276: 34941-34947. PMID: 11438529, DOI: 10.1074/jbc.m102997200.Peer-Reviewed Original ResearchConceptsExtended substrate specificitySubstrate specificitySubstrate specificity determinantsPreferred substrate sequenceBasic amino acidsSpecificity determinantsAdjacent protomersSubstrate librariesSubstrate sequenceGlu-217Thr-96Multiple substratesCleavage siteRelevant substratesAmino acidsPotent tryptase inhibitorExtended substrateStructural determinantsAsp-189Ground state substrateFunctional determinantsSpecificity dataTryptase inhibitorsBetaIMolecular docking
1994
Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85
Kaffman A, Herskowitz I, Tjian R, O'Shea E. Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85. Science 1994, 263: 1153-1156. PMID: 8108735, DOI: 10.1126/science.8108735.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAmino Acid SequenceCulture MediaCyclin-Dependent KinasesCyclinsDNA-Binding ProteinsFungal ProteinsGene Expression Regulation, FungalModels, GeneticMolecular Sequence DataPhosphatesPhosphorylationRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsConceptsCyclin-CDK complexesTranscription factor Pho4Cell cycle controlPho80-Pho85PHO5 transcriptionPho4Protein kinaseYeast cyclinNegative regulationRelevant substratesPHO80PHO2PHO5Regulatory processesPhosphorylationComplexesPho85TranscriptionHomologyKinaseHigh phosphateCyclinInteractsRegulationInduction
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